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TEP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151146

DOK1 Antibody: Signals from most growth factors and cytokines are transduced by receptor tyrosine kinases or non-receptor tyrosine kinases. Activated tyrosine kinases phosphorylate their substrates, which mediate the cellular response to extracellular… More details

$530 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DOK1 (TEP1), Polyclonal Antibody
Full Product Name
DOK1 Antibody
Product Gene Name
anti-TEP1 antibody
Product Synonym Names
DOK1; TP1; TLP1; p240; TROVE1; VAULT2; Docking protein 1; Downstream of tyrosine kinase 1; telomerase-associated protein 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
DOK1 Antibody is affinity chromatography purified via peptide column.
Preparation and Storage
DOK1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
DOK1 peptide (MBS152181) is used for blocking the activity of DOK1 antibody (MBS151146)
Molecular Weight
62 kDa
OMIM
601686
3D Structure
ModBase 3D Structure for Q99704
Conjugate
Unconjugated
Immunogen
DOK1 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human DOK1.
Buffer
DOK1 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-TEP1 antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-TEP1 antibody
DOK1 antibody can be used for detection of DOK1 expression by Western blot at 1 mug/mL. A 62 kDa band should be detected. Antibody can also be used for immunocytochemistry starting at 2 mug/mL. For immunofluorescence start at 10 mug/mL.

Western Blot (WB) of anti-TEP1 antibody

Western blot analysis of DOK1 in Jurkat (Jur) and THP-1 (THP) cell lysates with DOK1 antibody at 1 μg/mL.
Rabbit Anti-TEP1 Polyclonal Antibody – Cat# MBS151146

Immunocytochemistry (IHC) of anti-TEP1 antibody

Immunocytochemistry of DOK1 in K562 cells with DOK1 antibody at 2 μg/mL.
Rabbit Anti-TEP1 Polyclonal Antibody, Immunocytochemistry (IHC) – Cat# MBS151146

Immunofluorescence (IF) of anti-TEP1 antibody

Immunofluorescence of DOK1 in K562 cells with DOK1 antibody at 10 μg/ml.
Rabbit Anti-TEP1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS151146

Other Notes

Small volumes of anti-TEP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TEP1 purchase

MBS151146 is an antibody targeting TEP1. Also known as DOK1 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TEP1. It may not necessarily be applicable to this product.

NCBI GI #
1848277
NCBI GeneID
7011
NCBI Accession #
AAC51127
UniProt Primary Accession #
Q99704
UniProt Secondary Accession #
A0AUV9
UniProt Related Accession #
Q99973
NCBI Official Full Name
telomerase-associated protein TP-1
NCBI Official Synonym Full Names
telomerase-associated protein 1
NCBI Official Symbol
TEP1
NCBI Official Synonym Symbols
TP1; TLP1; p240; TROVE1; VAULT2
UniProt Protein Name
Telomerase protein component 1
UniProt Synonym Protein Names
Telomerase-associated protein 1; Telomerase protein 1; p240; p80 telomerase homolog
Protein Family
Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase
UniProt Gene Name
TEP1
UniProt Synonym Gene Names
TLP1; TP1; Telomerase protein 1
UniProt Entry Name
TEP1_HUMAN
NCBI Protein Information
telomerase protein component 1; telomerase protein 1; p80 telomerase homolog; TROVE domain family, member 1

NCBI Summary for TEP1

This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans. [provided by RefSeq, Jul 2008]

UniProt Comments for TEP1

DOK1: a docking protein that interacts with receptor tyrosine kinases. It is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 2p13

Cellular Component: perinuclear region of cytoplasm; cytoplasm; nucleus; cytosol

Molecular Function: protein binding; receptor signaling protein activity; insulin receptor binding

Biological Process: cell surface receptor linked signal transduction; Ras protein signal transduction; insulin receptor signaling pathway; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
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Research Articles on TEP1

1. 8 common SNPs in telomerase reverse transcriptase (TERT) and telomerase-associated protein 1 (TEP1) were genotyped.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TEP1 antibody

 Reference Product  PubMed Publications
 RET antibody  >2 publications with TEP1 and RET
 CSK antibody  >1 publications with TEP1 and CSK
 SRC antibody  >1 publications with TEP1 and SRC

Diseases associated with anti-TEP1 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >20 publications with TEP1 and Breast Neoplasms
 Stomach Neoplasms Antibodies  >10 publications with TEP1 and Stomach Neoplasms
 Liver Neoplasms Antibodies  >9 publications with TEP1 and Liver Neoplasms
 Liver Diseases Antibodies  >8 publications with TEP1 and Liver Diseases
 Leukemia Antibodies  >8 publications with TEP1 and Leukemia
 Endometrial Neoplasms Antibodies  >7 publications with TEP1 and Endometrial Neoplasms
 Carcinoma, Hepatocellular Antibodies  >7 publications with TEP1 and Carcinoma, Hepatocellular
 Urinary Bladder Neoplasms Antibodies  >7 publications with TEP1 and Urinary Bladder Neoplasms
 Prostatic Neoplasms Antibodies  >7 publications with TEP1 and Prostatic Neoplasms
 Inflammation Antibodies  >6 publications with TEP1 and Inflammation

Organs/Tissues associated with anti-TEP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >20 publications with TEP1 and Blood
 Liver Antibodies  >16 publications with TEP1 and Liver
 Brain Antibodies  >12 publications with TEP1 and Brain
 Prostate Antibodies  >10 publications with TEP1 and Prostate
 Lung Antibodies  >9 publications with TEP1 and Lung
 Kidney Antibodies  >8 publications with TEP1 and Kidney
 Skin Antibodies  >7 publications with TEP1 and Skin
 Uterus Antibodies  >6 publications with TEP1 and Uterus
 Muscle Antibodies  >6 publications with TEP1 and Muscle
 Intestine Antibodies  >5 publications with TEP1 and Intestine
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