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ELOVL6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151168

ELOVL6 Antibody: Lipogenesis is a key event in the energy storage system and is controlled by the transcription factor sterol regulatory element-binding protein (SREBP)-1. Elongation of very long chain fatty acids protein 6 (ELOVL6) is a member of fatty… More details

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Product Overview

Online Datasheet in PDF
Product Name
ELOVL6, Polyclonal Antibody
Full Product Name
ELOVL6 Antibody
Product Gene Name
anti-ELOVL6 antibody
Product Synonym Names
ELOVL6; FAE; LCE; FACE; Elongation of very long chain fatty acids protein 6; 3-keto acyl-CoA synthase ELOVL6; ELOVL FA elongase 6; ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
ELOVL6 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
ELOVL6 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
ELOVL6 peptide (MBS152225) is used for blocking the activity of ELOVL6 antibody (MBS151168)
Molecular Weight
31,376 Da
OMIM
611546
3D Structure
ModBase 3D Structure for Q9H5J4
Conjugate
Unconjugated
Immunogen
ELOVL6 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of the human ELOVL6.
Buffer
ELOVL6 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-ELOVL6 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-ELOVL6 antibody
ELOVL6 antibody can be used for detection of ELOVL6 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-ELOVL6 antibody

Western blot analysis of ELOVL6 in Human brain tissue lysate with ELOVL6 antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-ELOVL6 Polyclonal Antibody – Cat# MBS151168

Immunohistochemistry (IHC) of anti-ELOVL6 antibody

Immunohistochemistry of ELOVL6 in human brain tissue with ELOVL6 antibody at 5 μg/mL.
Rabbit Anti-ELOVL6 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS151168

Immunofluorescence (IF) of anti-ELOVL6 antibody

Immunofluorescence of ELOVL6 in Human Brain tissue with ELOVL6 antibody at 20 μg/mL.
Rabbit Anti-ELOVL6 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS151168

Other Notes

Small volumes of anti-ELOVL6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ELOVL6 purchase

MBS151168 is an antibody targeting ELOVL6. Also known as ELOVL6 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ELOVL6. It may not necessarily be applicable to this product.

NCBI GI #
13129088
NCBI GeneID
79071
NCBI Accession #
NP_076995
UniProt Primary Accession #
Q9H5J4
UniProt Secondary Accession #
Q4W5L0; Q8NCD1
UniProt Related Accession #
Q9H5J4
GenBank Nucleotide #
NM_024090.2
NCBI Official Full Name
elongation of very long chain fatty acids protein 6
NCBI Official Synonym Full Names
ELOVL fatty acid elongase 6
NCBI Official Symbol
ELOVL6
NCBI Official Synonym Symbols
FAE; LCE; FACE
UniProt Protein Name
Elongation of very long chain fatty acids protein 6
UniProt Synonym Protein Names
3-keto acyl-CoA synthase ELOVL6; ELOVL fatty acid elongase 6; ELOVL FA elongase 6; Fatty acid elongase 2; hELO2; Fatty acyl-CoA elongase; Long-chain fatty-acyl elongase; Very-long-chain 3-oxoacyl-CoA synthase 6
UniProt Gene Name
ELOVL6
UniProt Synonym Gene Names
FACE; LCE; ELOVL FA elongase 6; hELO2
UniProt Entry Name
ELOV6_HUMAN
NCBI Protein Information
elongation of very long chain fatty acids protein 6; hELO2; ELOVL FA elongase 6; fatty acid elongase 2; fatty acyl-CoA elongase; long-chain fatty-acyl elongase; 3-keto acyl-CoA synthase ELOVL6; very-long-chain 3-oxoacyl-CoA synthase 6; ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)

NCBI Summary for ELOVL6

Fatty acid elongases (EC 6.2.1.3), such as ELOVL6, use malonyl-CoA as a 2-carbon donor in the first and rate-limiting step of fatty acid elongation (Moon et al., 2001 [PubMed 11567032]).[supplied by OMIM, Mar 2008]

UniProt Comments for ELOVL6

ELOVL6: Condensing enzyme that catalyzes the synthesis of saturated and monounsaturated fatty acids. Highest activity toward C16:0 acyl-CoAs. Belongs to the ELO family.

Protein type: EC 2.3.1.199; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4q25

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to endoplasmic reticulum membrane

Molecular Function: protein binding; transferase activity, transferring groups other than amino-acyl groups

Biological Process: long-chain fatty acid biosynthetic process; triacylglycerol biosynthetic process; fatty acid elongation, saturated fatty acid; cellular lipid metabolic process
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Research Articles on ELOVL6

1. human liver samples from patients with Non-alcoholic steatohepatitis or Non-alcoholic steatohepatitis-related hepatocellular carcinoma showed an elevated expression of the elongase ELOVL6, which is responsible for the elongation of C16 fatty acids.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ELOVL6 antibody

 Reference Product  PubMed Publications
 SREBF1 antibody  >9 publications with ELOVL6 and SREBF1
 ACSL5 antibody  >1 publications with ELOVL6 and ACSL5
 ACSL1 antibody  >1 publications with ELOVL6 and ACSL1
 ACSL3 antibody  >1 publications with ELOVL6 and ACSL3
 SREBF2 antibody  >1 publications with ELOVL6 and SREBF2

Pathways associated with anti-ELOVL6 antibody

 Products by Pathway  Pathway Diagram
 Activation Of Gene Expression By SREBF (SREBP) Pathway antibodies  Activation Of Gene Expression By SREBF (SREBP) Pathway Diagram
 Biosynthesis Of Unsaturated Fatty Acids Pathway antibodies  Biosynthesis Of Unsaturated Fatty Acids Pathway Diagram
 Biosynthesis Of Unsaturated Fatty Acids Pathway antibodies  Biosynthesis Of Unsaturated Fatty Acids Pathway Diagram
 Fatty Acyl-CoA Biosynthesis Pathway antibodies  Fatty Acyl-CoA Biosynthesis Pathway Diagram
 Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway antibodies  Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway Diagram
 Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway antibodies  Fatty Acid Biosynthesis, Elongation, Endoplasmic Reticulum Pathway Diagram
 Fatty Acid Elongation Pathway antibodies  Fatty Acid Elongation Pathway Diagram
 Fatty Acid Elongation Pathway antibodies  Fatty Acid Elongation Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram

Diseases associated with anti-ELOVL6 antibody

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >42 publications with ELOVL6 and Fatty Liver
 Insulin Resistance Antibodies  >21 publications with ELOVL6 and Insulin Resistance
 Liver Diseases Antibodies  >14 publications with ELOVL6 and Liver Diseases
 Inflammation Antibodies  >12 publications with ELOVL6 and Inflammation
 Disease Models, Animal Antibodies  >9 publications with ELOVL6 and Disease Models, Animal
 Non-alcoholic Fatty Liver Disease Antibodies  >6 publications with ELOVL6 and Non-alcoholic Fatty Liver Disease
 Fibrosis Antibodies  >5 publications with ELOVL6 and Fibrosis
 Hyperglycemia Antibodies  >5 publications with ELOVL6 and Hyperglycemia
 Dyslipidemias Antibodies  >4 publications with ELOVL6 and Dyslipidemias
 Cardiovascular Diseases Antibodies  >4 publications with ELOVL6 and Cardiovascular Diseases

Organs/Tissues associated with anti-ELOVL6 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >44 publications with ELOVL6 and Liver
 Adipose Tissue Antibodies  >17 publications with ELOVL6 and Adipose Tissue
 Blood Antibodies  >14 publications with ELOVL6 and Blood
 Connective Tissue Antibodies  >12 publications with ELOVL6 and Connective Tissue
 Muscle Antibodies  >7 publications with ELOVL6 and Muscle
 Vascular Antibodies  >3 publications with ELOVL6 and Vascular
 Pancreas Antibodies  >3 publications with ELOVL6 and Pancreas
 Mammary Gland Antibodies  >2 publications with ELOVL6 and Mammary Gland
 Bone Marrow Antibodies  >2 publications with ELOVL6 and Bone Marrow
 Testis Antibodies  >2 publications with ELOVL6 and Testis
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