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MACC1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151243

MACC1 Antibody: Metastasis associated in colon cancer 1 (MACC1) is a key regulator of the hepatocyte growth factor (HGF)-HGF receptor (MET) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility,… More details

$530 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MACC1, Polyclonal Antibody
Full Product Name
MACC1 Antibody
Product Gene Name
anti-MACC1 antibody
Product Synonym Names
MACC1; 7A5; SH3BP4L; Metastasis-associated in colon cancer protein 1; SH3 domain-containing protein 7a5; metastasis associated in colon cancer 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
MACC1 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
At least two isoforms of MACC1 are known to exist.
Preparation and Storage
Antibody can be stored at 4 degree C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
MACC1 peptide (MBS152556) is used for blocking the activity of MACC1 antibody (MBS151243)
Molecular Weight
Predicted: 94 kDa

Observed: 90 kDa
OMIM
612646
3D Structure
ModBase 3D Structure for Q6ZN28
Conjugate
Unconjugated
Immunogen
MACC1 antibody was raised against a 17 amino acid synthetic peptide near the center of human MACC1.
Buffer
MACC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-MACC1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-MACC1 antibody
MACC1 antibody can be used for detection of MACC1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-MACC1 antibody

Western blot analysis of MACC1 in mouse liver tissue lysate with MACC1 antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-MACC1 Polyclonal Antibody – Cat# MBS151243

Immunohistochemistry (IHC) of anti-MACC1 antibody

Immunohistochemistry of MACC1 in human liver tissue with MACC1 antibody at 2.5 μg/mL.
Rabbit Anti-MACC1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS151243

Immunofluorescence (IF) of anti-MACC1 antibody

Immunofluorescence of MACC1 in Human Liver cells with MACC1 antibody at 20 μg/mL.
Rabbit Anti-MACC1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS151243

Western Blot (WB) of anti-MACC1 antibody

Western blot analysis of MACC1 expression in human liver tissue lysate with MACC1 antibody at (A) 1 and (B) 2 μg/ml.
Rabbit Anti-MACC1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS151243

Other Notes

Small volumes of anti-MACC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MACC1 purchase

MBS151243 is an antibody targeting MACC1. Also known as MACC1 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MACC1. It may not necessarily be applicable to this product.

NCBI GI #
157502191
NCBI GeneID
346389
NCBI Accession #
NP_877439
UniProt Primary Accession #
Q6ZN28
UniProt Secondary Accession #
Q6ZQN8; Q7Z5A5; A8MUS5; B2RNR9
UniProt Related Accession #
Q6ZN28
GenBank Nucleotide #
NM_182762.3
NCBI Official Full Name
metastasis-associated in colon cancer protein 1
NCBI Official Synonym Full Names
metastasis associated in colon cancer 1
NCBI Official Symbol
MACC1
NCBI Official Synonym Symbols
7A5; SH3BP4L
UniProt Protein Name
Metastasis-associated in colon cancer protein 1
UniProt Synonym Protein Names
SH3 domain-containing protein 7a5
Protein Family
Metastasis-associated in colon cancer protein
UniProt Gene Name
MACC1
UniProt Entry Name
MACC1_HUMAN
NCBI Protein Information
metastasis-associated in colon cancer protein 1; putative binding protein 7a5; SH3 domain-containing protein 7a5

NCBI Summary for MACC1

MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009]
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UniProt Comments for MACC1

MACC1: Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.

Chromosomal Location of Human Ortholog: 7p21.1

Cellular Component: cytoplasm; nucleus

Molecular Function: growth factor activity

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of cell division
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Research Articles on MACC1

1. Highly expressed MACC1 protein is associated with hepatocellular carcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MACC1 antibody

 Reference Product  PubMed Publications
 MET antibody  >40 publications with MACC1 and MET
 HGF antibody  >15 publications with MACC1 and HGF

Diseases associated with anti-MACC1 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >17 publications with MACC1 and Adenocarcinoma
 Lung Diseases Antibodies  >5 publications with MACC1 and Lung Diseases
 Cell Transformation, Neoplastic Antibodies  >3 publications with MACC1 and Cell Transformation, Neoplastic
 Ovarian Neoplasms Antibodies  >3 publications with MACC1 and Ovarian Neoplasms
 Ovarian Diseases Antibodies  >3 publications with MACC1 and Ovarian Diseases
 Inflammation Antibodies  >2 publications with MACC1 and Inflammation
 Postoperative Complications Antibodies  >1 publications with MACC1 and Postoperative Complications
 Breast Neoplasms Antibodies  >1 publications with MACC1 and Breast Neoplasms
 Disease Models, Animal Antibodies  >1 publications with MACC1 and Disease Models, Animal
 Necrosis Antibodies  >1 publications with MACC1 and Necrosis

Organs/Tissues associated with anti-MACC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >16 publications with MACC1 and Liver
 Lymph Node Antibodies  >13 publications with MACC1 and Lymph Node
 Lung Antibodies  >7 publications with MACC1 and Lung
 Stomach Antibodies  >4 publications with MACC1 and Stomach
 Brain Antibodies  >2 publications with MACC1 and Brain
 Ovary Antibodies  >1 publications with MACC1 and Ovary
 Embryonic Tissue Antibodies  >1 publications with MACC1 and Embryonic Tissue
 Kidney Antibodies  >1 publications with MACC1 and Kidney
 Intestine Antibodies  >1 publications with MACC1 and Intestine
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