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WDR5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151253

WDR5 Antibody: WD repeat domain 5 (WDR5) is a member of the WD repeat protein family, which is involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WDR5, also known as BIG-3, is… More details

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Product Overview

Online Datasheet in PDF
Product Name
WDR5, Polyclonal Antibody
Full Product Name
WDR5 Antibody
Product Gene Name
anti-WDR5 antibody
Product Synonym Names
WDR5; SWD3; BIG-3; BIG3; WD repeat-containing protein 5; BMP2-induced 3-kb gene protein; WD repeat domain 5
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
WDR5 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
WDR5 antibody is human specific. WDR5 antibody is predicted to not cross-react with other WDR family members.
Preparation and Storage
WDR5 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
WDR5 peptide (MBS152365) is used for blocking the activity of WDR5 antibody (MBS151253)
Molecular Weight
36,588 Da
OMIM
609012
3D Structure
ModBase 3D Structure for P61964
Conjugate
Unconjugated
Immunogen
WDR5 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human WDR5.
Buffer
WDR5 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-WDR5 antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-WDR5 antibody
WDR5 antibody can be used for detection of WDR5 by Western blot at 1 mug/mL. Antibody can also be used for immunocytochemistry starting at 5 mug/mL. For immunofluorescence start at 5 mug/mL.

Western Blot (WB) of anti-WDR5 antibody

Western blot analysis of WDR5 in 293 cell lysate with WDR5 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
Rabbit Anti-WDR5 Polyclonal Antibody – Cat# MBS151253

Immunocytochemistry (IHC) of anti-WDR5 antibody

Immunocytochemistry of WDR5 in 293 cells with WDR5 antibody at 5 μg/mL.
Rabbit Anti-WDR5 Polyclonal Antibody, Immunocytochemistry (IHC) – Cat# MBS151253

Immunofluorescence (IF) of anti-WDR5 antibody

Immunofluorescence of WDR5 in 293 cells with WDR5 antibody at 20 μg/mL.
Rabbit Anti-WDR5 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS151253

Other Notes

Small volumes of anti-WDR5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for WDR5 purchase

MBS151253 is an antibody targeting WDR5. Also known as WDR5 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for WDR5. It may not necessarily be applicable to this product.

NCBI GI #
16554627
NCBI GeneID
11091
NCBI Accession #
NP_060058
UniProt Primary Accession #
P61964
UniProt Secondary Accession #
Q91VA5; Q9NWX7; Q9UGP9
UniProt Related Accession #
P61964
GenBank Nucleotide #
NM_017588.2
NCBI Official Full Name
WD repeat-containing protein 5
NCBI Official Synonym Full Names
WD repeat domain 5
NCBI Official Symbol
WDR5
NCBI Official Synonym Symbols
SWD3; BIG-3; CFAP89
UniProt Protein Name
WD repeat-containing protein 5
UniProt Synonym Protein Names
BMP2-induced 3-kb gene protein
Protein Family
WD repeat-containing protein
UniProt Gene Name
WDR5
UniProt Synonym Gene Names
BIG3
UniProt Entry Name
WDR5_HUMAN
NCBI Protein Information
WD repeat-containing protein 5; WD-repeat protein 5; BMP2-induced 3-kb gene protein; SWD3, Set1c WD40 repeat protein, homolog; cilia and flagella associated protein 89

NCBI Summary for WDR5

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
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UniProt Comments for WDR5

WDR5: a WD40 repeat protein. May accelerate osteoblast differentiation. Interacts with HCFC1. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: nucleoplasm; histone methyltransferase complex; nucleus; histone acetyltransferase complex

Molecular Function: protein binding; histone lysine N-methyltransferase activity (H3-K4 specific); histone acetyltransferase activity (H4-K16 specific)

Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; histone H3-K4 methylation; skeletal development
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Research Articles on WDR5

1. results identify WDR5 as a critical epigenomic integrator of histone phosphorylation and methylation and as a major driver of androgen-dependent prostate cancer cell proliferation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-WDR5 antibody

 Reference Product  PubMed Publications
 MLL antibody  >56 publications with WDR5 and MLL
 RBBP5 antibody  >40 publications with WDR5 and RBBP5
 ASH2L antibody  >37 publications with WDR5 and ASH2L
 MLL2 antibody  >12 publications with WDR5 and MLL2
 SETD1A antibody  >11 publications with WDR5 and SETD1A
 HCFC1 antibody  >4 publications with WDR5 and HCFC1
 CHD8 antibody  >2 publications with WDR5 and CHD8
 SETD1B antibody  >1 publications with WDR5 and SETD1B

Pathways associated with anti-WDR5 antibody

 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 HATs Acetylate Histones Pathway antibodies  HATs Acetylate Histones Pathway Diagram
 PKMTs Methylate Histone Lysines Pathway antibodies  PKMTs Methylate Histone Lysines Pathway Diagram
 RMTs Methylate Histone Arginines Pathway antibodies  RMTs Methylate Histone Arginines Pathway Diagram

Diseases associated with anti-WDR5 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >4 publications with WDR5 and Necrosis
 Inflammation Antibodies  >2 publications with WDR5 and Inflammation
 Fibrosis Antibodies  >2 publications with WDR5 and Fibrosis
 Hyperglycemia Antibodies  >2 publications with WDR5 and Hyperglycemia
 Insulin Resistance Antibodies  >2 publications with WDR5 and Insulin Resistance
 Prostatic Diseases Antibodies  >2 publications with WDR5 and Prostatic Diseases
 Adenocarcinoma Antibodies  >2 publications with WDR5 and Adenocarcinoma
 Heart Diseases Antibodies  >1 publications with WDR5 and Heart Diseases
 Liver Diseases Antibodies  >1 publications with WDR5 and Liver Diseases
 Kidney Diseases Antibodies  >1 publications with WDR5 and Kidney Diseases

Organs/Tissues associated with anti-WDR5 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >14 publications with WDR5 and Bone
 Blood Antibodies  >8 publications with WDR5 and Blood
 Muscle Antibodies  >6 publications with WDR5 and Muscle
 Embryonic Tissue Antibodies  >6 publications with WDR5 and Embryonic Tissue
 Connective Tissue Antibodies  >3 publications with WDR5 and Connective Tissue
 Heart Antibodies  >3 publications with WDR5 and Heart
 Kidney Antibodies  >2 publications with WDR5 and Kidney
 Liver Antibodies  >2 publications with WDR5 and Liver
 Pancreas Antibodies  >2 publications with WDR5 and Pancreas
 Brain Antibodies  >2 publications with WDR5 and Brain
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