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CALHM1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151258

CALHM1 Antibody: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a massive loss of neurons in several brain regions and by the presence of senile plaques comprised of aggregated amyloid-beta (Abeta) peptides produced by… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CALHM1, Polyclonal Antibody
Full Product Name
CALHM1 Antibody
Product Gene Name
anti-CALHM1 antibody
Product Synonym Names
CALHM1; FAM26C; FAM26C; Calcium homeostasis modulator protein 1; Protein FAM26C; calcium homeostasis modulator 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
CALHM1 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
CALHM1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
CALHM1 peptide (MBS153260) is used for blocking the activity of CALHM1 antibody (MBS151258)
Molecular Weight
38,264 Da
OMIM
612234
3D Structure
ModBase 3D Structure for Q8IU99
Conjugate
Unconjugated
Immunogen
CALHM1 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human CALHM1.
Buffer
CALHM1 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-CALHM1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-CALHM1 antibody
CALHM1 antibody can be used for detection of CALHM1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-CALHM1 antibody

Western blot analysis of CALHM1 in rat liver tissue lysate with CALHM1 antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-CALHM1 Polyclonal Antibody – Cat# MBS151258

Immunohistochemistry (IHC) of anti-CALHM1 antibody

Immunohistochemistry of CALHM1 in rat liver tissue with CALHM1 antibody at 5 μg/mL.
Rabbit Anti-CALHM1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS151258

Immunofluorescence (IF) of anti-CALHM1 antibody

Immunofluorescence of CALHM1 in Rat Liver cells with CALHM1 antibody at 20 μg/mL.
Rabbit Anti-CALHM1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS151258

Other Notes

Small volumes of anti-CALHM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CALHM1 purchase

MBS151258 is an antibody targeting CALHM1. Also known as CALHM1 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CALHM1. It may not necessarily be applicable to this product.

NCBI GI #
194440685
NCBI GeneID
255022
NCBI Accession #
NP_001001412
UniProt Primary Accession #
Q8IU99
UniProt Secondary Accession #
Q5W091
UniProt Related Accession #
Q8IU99
GenBank Nucleotide #
NM_001001412.3
NCBI Official Full Name
calcium homeostasis modulator protein 1
NCBI Official Synonym Full Names
calcium homeostasis modulator 1
NCBI Official Symbol
CALHM1
NCBI Official Synonym Symbols
FAM26C
UniProt Protein Name
Calcium homeostasis modulator protein 1
UniProt Synonym Protein Names
Protein FAM26C
Protein Family
Calcium homeostasis modulator protein
UniProt Gene Name
CALHM1
UniProt Synonym Gene Names
FAM26C
UniProt Entry Name
CAHM1_HUMAN
NCBI Protein Information
calcium homeostasis modulator protein 1; family with sequence similarity 26, member C

NCBI Summary for CALHM1

This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.[provided by RefSeq, Mar 2010]
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UniProt Comments for CALHM1

CALHM1: May be a pore-forming ion channel. Controls cytosolic Ca(2+) permeability and cytosolic Ca(2+) concentration. Controls amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner. Belongs to the FAM26 family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium

Chromosomal Location of Human Ortholog: 10q24.33

Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane

Molecular Function: identical protein binding; calcium channel activity; voltage-gated ion channel activity; calcium activated cation channel activity

Biological Process: ATP transport; sensory perception of umami taste; sensory perception of sweet taste; sensory perception of bitter taste; cation transport; protein homooligomerization
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Research Articles on CALHM1

1. CALHM1 p.P86L variation may not be an AD susceptibility factor in the Han Chinese population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CALHM1 antibody

 Reference Product  PubMed Publications
 TMEM44 antibody  >1 publications with CALHM1 and TMEM44
 APP antibody  >1 publications with CALHM1 and APP

Organs/Tissues associated with anti-CALHM1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with CALHM1 and Brain
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