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JMJD1C Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151278

JMJD1C Antibody: The jumonji domain containing 1C protein (JMJD1C) was initially discovered in silico, and later suggested to be a candidate gene for autism. Like the related proteins JMJD1A and JMJD1B, JMJD1C is a histone H3K9 demethylase implicated in the… More details

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Product Overview

Online Datasheet in PDF
Product Name
JMJD1C, Polyclonal Antibody
Full Product Name
JMJD1C Antibody
Product Gene Name
anti-JMJD1C antibody
Product Synonym Names
JMJD1C; TRIP8; JHDM2C; KIAA1380; TRIP8; Probable JmjC domain-containing histone demethylation protein 2C; Jumonji domain-containing protein 1C; TR-interacting protein 8; jumonji domain containing 1C
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
JMJD1C Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
This antibody will not cross-react with JMJD1A or JMJD1B.
Preparation and Storage
JMJD1C antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
JMJD1C peptide (MBS153018) is used for blocking the activity of JMJD1C antibody (MBS151278)
Molecular Weight
263,157 Da
OMIM
604503
3D Structure
ModBase 3D Structure for Q15652
Conjugate
Unconjugated
Immunogen
JMJD1C antibody was raised against a 20 amino acid synthetic peptide from near the amino terminus of human JMJD1C.
Buffer
JMJD1C Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-JMJD1C antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-JMJD1C antibody
JMJD1C antibody can be used for detection of JMJD1C by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-JMJD1C antibody

Western blot analysis of JMJD1C in human liver tissue lysate with JMJD1C antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-JMJD1C Polyclonal Antibody – Cat# MBS151278

Immunohistochemistry (IHC) of anti-JMJD1C antibody

Immunohistochemistry of JMJD1C in rat liver tissue with JMJD1C antibody at 2.5 μg/mL.
Rabbit Anti-JMJD1C Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS151278

Immunofluorescence (IF) of anti-JMJD1C antibody

Immunofluorescence of JMJD1C in rat liver tissue with JMJD1C antibody at 20 μg/mL.
Rabbit Anti-JMJD1C Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS151278

Other Notes

Small volumes of anti-JMJD1C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for JMJD1C purchase

MBS151278 is an antibody targeting JMJD1C. Also known as JMJD1C Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for JMJD1C. It may not necessarily be applicable to this product.

NCBI GI #
118600981
NCBI GeneID
221037
NCBI Accession #
NP_116165
UniProt Primary Accession #
Q15652
UniProt Secondary Accession #
Q5SQZ8; Q5SQZ9; Q5SR00; Q7Z3E7; Q8N3U0; Q96KB9; Q9P2G7; A0T124
UniProt Related Accession #
Q15652
GenBank Nucleotide #
NM_032776.2
NCBI Official Full Name
probable JmjC domain-containing histone demethylation protein 2C isoform a
NCBI Official Synonym Full Names
jumonji domain containing 1C
NCBI Official Symbol
JMJD1C
NCBI Official Synonym Symbols
TRIP8
UniProt Protein Name
Probable JmjC domain-containing histone demethylation protein 2C
UniProt Synonym Protein Names
Jumonji domain-containing protein 1C; Thyroid receptor-interacting protein 8; TR-interacting protein 8; TRIP-8
Protein Family
Probable JmjC domain-containing histone demethylation protein
UniProt Gene Name
JMJD1C
UniProt Synonym Gene Names
JHDM2C; KIAA1380; TRIP8; TR-interacting protein 8; TRIP-8
UniProt Entry Name
JHD2C_HUMAN
NCBI Protein Information
probable JmjC domain-containing histone demethylation protein 2C; TRIP-8; TR-interacting protein 8; jumonji domain-containing protein 1C; thyroid hormone receptor interactor 8; thyroid receptor interacting protein 8; thyroid receptor-interacting protein 8

UniProt Comments for JMJD1C

TRIP8: Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes. Belongs to the JHDM2 histone demethylase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor; EC 1.14.11.-; Oxidoreductase; Nuclear receptor co-regulator; Demethylase

Chromosomal Location of Human Ortholog: 10q21.3

Cellular Component: nucleoplasm; intracellular

Molecular Function: protein binding; dioxygenase activity; metal ion binding; thyroid hormone receptor binding

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; chromatin modification; blood coagulation
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Research Articles on JMJD1C

1. Depletion of JMJD1C impairs expansion and colony formation of leukemic cell lines, with the strongest effect observed in the MLL-rearranged ALL cell line SEM.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-JMJD1C antibody

 Reference Product  PubMed Publications
 DPF3 antibody  >1 publications with JMJD1C and DPF3

Pathways associated with anti-JMJD1C antibody

 Products by Pathway  Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram

Diseases associated with anti-JMJD1C antibody

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >1 publications with JMJD1C and Mental Disorders
 Hypertrophy Antibodies  >1 publications with JMJD1C and Hypertrophy
 Heart Diseases Antibodies  >1 publications with JMJD1C and Heart Diseases
 Liver Diseases Antibodies  >1 publications with JMJD1C and Liver Diseases
 Cognition Disorders Antibodies  >1 publications with JMJD1C and Cognition Disorders
 Inflammation Antibodies  >1 publications with JMJD1C and Inflammation
 Nervous System Diseases Antibodies  >1 publications with JMJD1C and Nervous System Diseases
 Autistic Disorder Antibodies  >1 publications with JMJD1C and Autistic Disorder

Organs/Tissues associated with anti-JMJD1C antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with JMJD1C and Blood
 Heart Antibodies  >6 publications with JMJD1C and Heart
 Brain Antibodies  >4 publications with JMJD1C and Brain
 Muscle Antibodies  >3 publications with JMJD1C and Muscle
 Thyroid Antibodies  >2 publications with JMJD1C and Thyroid
 Testis Antibodies  >2 publications with JMJD1C and Testis
 Liver Antibodies  >2 publications with JMJD1C and Liver
 Prostate Antibodies  >2 publications with JMJD1C and Prostate
 Intestine Antibodies  >1 publications with JMJD1C and Intestine
 Lung Antibodies  >1 publications with JMJD1C and Lung
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