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CD180 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151279

RP105 Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and… More details

$530 / 0.1 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
RP105 (CD180), Polyclonal Antibody
Full Product Name
RP105 Antibody
Product Gene Name
Product Synonym Names
RP105; LY64; Ly78; RP105; LY64; CD180 antigen; Lymphocyte antigen 64; CD180 molecule
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
RP105 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
RP105 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
RP105 peptide (MBS152004) is used for blocking the activity of RP105 antibody (MBS151279)
Molecular Weight
74,179 Da
OMIM
602226
3D Structure
ModBase 3D Structure for Q99467
Conjugate
Unconjugated
Immunogen
RP105 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human RP105.
Buffer
RP105 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-CD180 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CD180 antibody
RP105 antibody can be used for the detection of RP105 by Western blot at 0.5 - 1 mug/mL. Despite its predicted molecular weight, RP105 often migrates at 95 - 105 kDa. Antibody can also be used for immunohistochemistry starting at 10 mug/mL.

Western Blot (WB) of anti-CD180 antibody

Western blot analysis of RP105 in human spleen tissue lysate with RP105 antibody at (A) 0.5 and (B) 1 μg/mL.
Rabbit Anti-CD180 Polyclonal Antibody – Cat# MBS151279

Immunohistochemistry (IHC) of anti-CD180 antibody

Immunohistochemistry of RP105 in human spleen tissue withRP105 antibody at 10 μg/mL.
Rabbit Anti-CD180 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS151279

Other Notes

Small volumes of anti-CD180 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD180 purchase

MBS151279 is an antibody targeting CD180. Also known as RP105 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD180. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
RP105
NCBI Official Synonym Full Names
CD180 molecule
NCBI Official Symbol
CD180
NCBI Official Synonym Symbols
LY64; Ly78; RP105
UniProt Protein Name
CD180 antigen
UniProt Synonym Protein Names
Lymphocyte antigen 64; Radioprotective 105 kDa protein; CD_antigen: CD180
Protein Family
UniProt Gene Name
CD180
UniProt Synonym Gene Names
LY64; RP105
UniProt Entry Name
CD180_HUMAN
NCBI Protein Information
CD180 antigen; lymphocyte antigen 64; radioprotective 105 kDa protein; lymphocyte antigen-64, radioprotective, 105kDa

NCBI Summary for CD180

CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]
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UniProt Comments for CD180

CD180: May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells. Belongs to the Toll-like receptor family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q12

Cellular Component: plasma membrane; integral to membrane

Biological Process: positive regulation of lipopolysaccharide-mediated signaling pathway; innate immune response; inflammatory response; B cell proliferation during immune response
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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