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Caspase-14 (CASP14) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151361

Caspase-14 Antibody: Caspases are a family of cysteine proteases that can be divided into apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are… More details

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Product Overview

Online Datasheet in PDF
Product Name
Caspase-14 (Casp14), Polyclonal Antibody
Full Product Name
Caspase-14 Antibody
Product Gene Name
anti-Casp14 antibody
Product Synonym Names
Caspase-14; MICE; mini-ICE; Caspase-14; Mini-ICE; CASP-14; caspase 14
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
Caspase-14 Antibody is affinity chromatography purified via peptide column.
Preparation and Storage
Antibody can be stored at 4 degree C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
Caspase-14 peptide (MBS153204) is used for blocking the activity of Caspase-14 antibody (MBS151361)
Molecular Weight
18,224 Da
3D Structure
ModBase 3D Structure for O89094
Conjugate
Unconjugated
Immunogen
Caspase-14 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human caspase-14.
Buffer
Caspase-14 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-Casp14 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-Casp14 antibody
Caspase-14 antibody can be used for the detection of caspase-14 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL.

Western Blot (WB) of anti-Casp14 antibody

Western blot analysis of caspase-14 in Jurkat cell lysate in the (A) absence or (B) presence of blocking peptide with caspase-14 antibody at 1 μg/mL.
Rabbit Anti-CASP14 Polyclonal Antibody – Cat# MBS151361

Immunohistochemistry (IHC) of anti-Casp14 antibody

Immunohistochemistry of caspase-14 in human liver tissue with caspase-14 antibody at 2.5 μg/mL.
Rabbit Anti-CASP14 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS151361

Other Notes

Small volumes of anti-Casp14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Casp14 purchase

MBS151361 is an antibody targeting Casp14. Also known as Caspase-14 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Casp14. It may not necessarily be applicable to this product.

NCBI GI #
6753280
NCBI GeneID
12365
NCBI Accession #
NP_033939
UniProt Primary Accession #
O89094
UniProt Related Accession #
O89094
GenBank Nucleotide #
NM_009809.5
NCBI Official Full Name
caspase-14
NCBI Official Synonym Full Names
caspase 14
NCBI Official Symbol
Casp14
NCBI Official Synonym Symbols
MICE; mini-ICE
UniProt Protein Name
Caspase-14
UniProt Synonym Protein Names
Mini-ICE; MICE
Protein Family
Caspase
UniProt Gene Name
Casp14
UniProt Synonym Gene Names
CASP-14; MICE
UniProt Entry Name
CASPE_MOUSE
NCBI Protein Information
caspase-14; CASP-14

UniProt Comments for Casp14

CASP14: Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolytically processing filaggrin. Complex of unprocessed caspase-14 and processed 19 kDa (p19) and 10 kDa (p10) subunits. In undifferentiated keratinocytes under postconfluency growth conditions (in vitro). Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum). Expressed in keratinocytes of hair shaft and sebaceous glands. In psoriatic skin only expressed at very low levels. Belongs to the peptidase C14A family.

Protein type: EC 3.4.22.-; Protease

Cellular Component: keratin filament; cytoplasm; nucleus

Molecular Function: peptidase activity; hydrolase activity; cysteine-type peptidase activity

Biological Process: caspase activation; DNA damage response, signal transduction resulting in induction of apoptosis; apoptosis; cell differentiation; proteolysis
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Research Articles on Casp14

1. Mesotrypsin generated saposins A-D from prosaposin, and mature caspase-14 contributed to this process by activating mesotrypsinogen to mesotrypsin. Knockdown of these proteases markedly down-regulated saposin A synthesis in skin equivalent models.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Casp14 antibody

 Reference Product  PubMed Publications
 Krt10 antibody  >1 publications with Casp14 and Krt10
 Krt71 antibody  >1 publications with Casp14 and Krt71
 Krt1 antibody  >1 publications with Casp14 and Krt1

Diseases associated with anti-Casp14 antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >5 publications with Casp14 and Brain Diseases
 Skin Neoplasms Antibodies  >4 publications with Casp14 and Skin Neoplasms
 Cardiovascular Diseases Antibodies  >3 publications with Casp14 and Cardiovascular Diseases
 Inflammation Antibodies  >3 publications with Casp14 and Inflammation
 Necrosis Antibodies  >2 publications with Casp14 and Necrosis
 Carcinoma, Hepatocellular Antibodies  >2 publications with Casp14 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with Casp14 and Liver Neoplasms
 Nerve Degeneration Antibodies  >1 publications with Casp14 and Nerve Degeneration
 Neoplasms, Experimental Antibodies  >1 publications with Casp14 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >1 publications with Casp14 and Lung Neoplasms

Organs/Tissues associated with anti-Casp14 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >34 publications with Casp14 and Skin
 Embryonic Tissue Antibodies  >5 publications with Casp14 and Embryonic Tissue
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