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RGS21 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151421

RGS21 Antibody: Regulator of G-protein signaling (RGS) proteins contain an 120 amino acid conserved domain, termed the RGS domain, that acts as a GTPase-activating protein that acts to reduce the signal transmitted by the receptor-activated G-alpha subunit.… More details

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Product Overview

Online Datasheet in PDF
Product Name
RGS21, Polyclonal Antibody
Full Product Name
RGS21 Antibody
Product Gene Name
anti-RGS21 antibody
Product Synonym Names
RGS21; Regulator of G-protein signaling 21; RGS21; regulator of G-protein signaling 21
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
RGS21 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
RGS21 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
RGS21 peptide (MBS152168) is used for blocking the activity of RGS21 antibody (MBS151421)
Molecular Weight
17,671 Da
OMIM
612407
3D Structure
ModBase 3D Structure for Q2M5E4
Conjugate
Unconjugated
Immunogen
RGS21 antibody was raised against a 16 amino acid synthetic peptide near the center of human RGS21.
Buffer
RGS21 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-RGS21 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-RGS21 antibody
RGS21 antibody can be used for detection of RGS21 by Western blot at 0.5 mug/mL. Antibody can also be used for immunocytochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-RGS21 antibody

Western blot analysis of RGS21 in HepG2 cell lysate with RGS21 antibody at 0.5 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Rabbit Anti-RGS21 Polyclonal Antibody – Cat# MBS151421

Immunocytochemistry (IHC) of anti-RGS21 antibody

Immunocytochemistry of RGS21 in HepG2 cells with RGS21 antibody at 2.5 μg/mL.
Rabbit Anti-RGS21 Polyclonal Antibody, Immunocytochemistry (IHC) – Cat# MBS151421

Immunofluorescence (IF) of anti-RGS21 antibody

Immunofluorescence of RGS21 in HepG2 cells with RGS21 antibody at 20 μg/mL.
Rabbit Anti-RGS21 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS151421

Immunofluorescence (IF) of anti-RGS21 antibody

Immunofluorescence of RGS21 in HepG2 cells with RGS21 antibody at 20 μg/mL.

Green: RGS21 Antibody (5209)
Blue: DAPI staining
Rabbit Anti-RGS21 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS151421

Other Notes

Small volumes of anti-RGS21 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RGS21 purchase

MBS151421 is an antibody targeting RGS21. Also known as RGS21 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RGS21. It may not necessarily be applicable to this product.

NCBI GI #
85540441
NCBI GeneID
431704
NCBI Accession #
NP_001034241
UniProt Primary Accession #
Q2M5E4
UniProt Related Accession #
Q2M5E4
GenBank Nucleotide #
NM_001039152.3
NCBI Official Full Name
regulator of G-protein signaling 21
NCBI Official Synonym Full Names
regulator of G-protein signaling 21
NCBI Official Symbol
RGS21
UniProt Protein Name
Regulator of G-protein signaling 21
Protein Family
Regulator of G-protein signaling
UniProt Gene Name
RGS21
UniProt Synonym Gene Names
RGS21
UniProt Entry Name
RGS21_HUMAN
NCBI Protein Information
regulator of G-protein signaling 21; regulator of G-protein signalling 21

NCBI Summary for RGS21

Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM, Nov 2008]
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UniProt Comments for RGS21

RGS21: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.

Protein type: GAPs; GAPs, misc.

Chromosomal Location of Human Ortholog: 1q31.2

Cellular Component: cytoplasm; plasma membrane

Molecular Function: GTPase activator activity

Biological Process: positive regulation of GTPase activity
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Research Articles on RGS21

1. RGS21 modulates bitter taste signal transduction.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-RGS21 antibody

 Products by Pathway  Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
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