Chicken Anti-SPATA18 Polyclonal Antibody – Cat# MBS151481

Western blot analysis of SPATA18 in rat lung tissue lysate with SPATA18 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide

SPATA18 Antibody – Chicken Polyclonal

Name: SPATA18 Antibody; Polyclonal; Chicken; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS151481
Price: 530 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151481

SPATA18 Antibody: SPATA18, also known as SPETEX-1, was initially identified as a cytoplasmic protein of elongate spermatids that is thought to be involved in differentiation process of elongate spermatids to mature spermatozoa. Recent experiments have shown… More details

$530 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SPATA18, Polyclonal Antibody

Full Product Name

SPATA18 Antibody

Product Gene Name

anti-SPATA18 antibody

Product Synonym Names

SPATA18; Mieap; SPETEX1; MIEAP; Mitochondria-eating protein; Spermatogenesis-associated protein 18; spermatogenesis associated 18

Clonality

Polyclonal

Isotype

IgY

Host

Chicken

Species Reactivity

Human, Mouse, Rat

Form/Format

Liquid

Purity/Purification

SPATA18 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL (lot specific)

Specificity

At least three isoforms of SPATA18 are known to exist; this antibody will detect the two longest isoforms. SPATA18 antibody is predicted to not cross-react with other SPATA family members.

Preparation and Storage

SPATA18 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Antibody/Peptide Pairs

SPATA18 peptide (MBS151829) is used for blocking the activity of SPATA18 antibody (MBS151481)

Molecular Weight

57,485 Da

OMIM

612814

3D Structure

ModBase 3D Structure for Q8TC71

Conjugate

Unconjugated

Immunogen

SPATA18 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human SPATA18.

Buffer

SPATA18 Antibody is supplied in PBS containing 0.02% sodium azide.

Applications Tested/Suitable for anti-SPATA18 antibody

ELISA (EIA), Western Blot (WB)

Application Notes for anti-SPATA18 antibody

SPATA18 antibody can be used for detection of SPATA18 by Western blot at 1 mug/mL.

Other Notes

Small volumes of anti-SPATA18 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SPATA18 purchase

MBS151481 is an antibody targeting SPATA18. Also known as SPATA18 Antibody. Reactive in Human, Mouse, Rat. Host: Chicken.

Additional Details

NCBI/Uniprot data below describe general gene information for SPATA18. It may not necessarily be applicable to this product.

NCBI GI #

21687119

NCBI GeneID

132671

NCBI Accession #

NP_660306

UniProt Primary Accession #

Q8TC71

UniProt Secondary Accession #

Q8IY48; Q8N7D7; B4E2R0; E5RLK1

UniProt Related Accession #

Q8TC71

GenBank Nucleotide #

NM_145263.3

NCBI Official Full Name

mitochondria-eating protein isoform 1

NCBI Official Synonym Full Names

spermatogenesis associated 18

NCBI Official Symbol

SPATA18

NCBI Official Synonym Symbols

Mieap; SPETEX1

UniProt Protein Name

Mitochondria-eating protein

UniProt Synonym Protein Names

Spermatogenesis-associated protein 18

Protein Family

Mitochondria-eating protein

UniProt Gene Name

SPATA18

UniProt Synonym Gene Names

MIEAP

UniProt Entry Name

MIEAP_HUMAN

NCBI Protein Information

mitochondria-eating protein; spermatogenesis associated 18 homolog; spermatogenesis-associated protein 18

UniProt Comments for SPATA18

SPATA18: Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Belongs to the MIEAP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial

Chromosomal Location of Human Ortholog: 4q12

Cellular Component: mitochondrial outer membrane; intracellular membrane-bound organelle; cytoplasm

Molecular Function: protein binding

Biological Process: response to DNA damage stimulus

Research Articles on SPATA18

1. The physical interaction of Mieap, BNIP3 and NIX at the mitochondrial outer membrane may play a critical role in the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SPATA18 antibody

Reference Product	PubMed Publications
SGCB antibody	>1 publications with SPATA18 and SGCB

Diseases associated with anti-SPATA18 antibody

Disease Name	Pubmed Publications
Urinary Bladder Neoplasms Antibodies	>1 publications with SPATA18 and Urinary Bladder Neoplasms

Organs/Tissues associated with anti-SPATA18 antibody

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>3 publications with SPATA18 and Testis