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NLRX1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151491

NOD5 Antibody: NOD5, also known as NLRX1, is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD5 localizes to the mitochondrial outer membrane and interacts with the… More details

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Product Overview

Online Datasheet in PDF
Product Name
NOD5 (NLRX1), Polyclonal Antibody
Full Product Name
NOD5 Antibody
Product Gene Name
anti-NLRX1 antibody
Product Synonym Names
NOD5; NOD5; NOD9; NOD26; DLNB26; CLR11.3; NOD5; NLR family member X1; Nucleotide-binding oligomerization domain protein 26; NLR family member X1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
NOD5 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
NOD5 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
NOD5 peptide (MBS151954) is used for blocking the activity of NOD5 antibody (MBS151491)
Molecular Weight
101,876 Da
OMIM
611947
3D Structure
ModBase 3D Structure for Q86UT6
Conjugate
Unconjugated
Immunogen
NOD5 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human NOD5.
Buffer
NOD5 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-NLRX1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-NLRX1 antibody
NOD5 antibody can be used for detection of NOD5 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-NLRX1 antibody

Western blot analysis of NOD5 in rat spleen tissue cell lysate with NOD5 antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-NLRX1 Polyclonal Antibody – Cat# MBS151491

Immunohistochemistry (IHC) of anti-NLRX1 antibody

Immunohistochemistry of NOD5 in rat spleen tissue with NOD5 antibody at 10 μg/mL.
Rabbit Anti-NLRX1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS151491

Immunofluorescence (IF) of anti-NLRX1 antibody

Immunofluorescence of NOD5 in rat spleen tissue with NOD5 antibody at 20 μg/mL.
Rabbit Anti-NLRX1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS151491

Other Notes

Small volumes of anti-NLRX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NLRX1 purchase

MBS151491 is an antibody targeting NLRX1. Also known as NOD5 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NLRX1. It may not necessarily be applicable to this product.

NCBI GI #
25777608
NCBI GeneID
79671
NCBI Accession #
NP_078894
UniProt Primary Accession #
Q86UT6
UniProt Secondary Accession #
Q7RTR3; Q96D51; Q9H724; A8K6Q1; B3KPK2; B3KTA2
UniProt Related Accession #
Q86UT6
GenBank Nucleotide #
NM_024618.3
NCBI Official Full Name
NLR family member X1
NCBI Official Synonym Full Names
NLR family member X1
NCBI Official Symbol
NLRX1
NCBI Official Synonym Symbols
NOD5; NOD9; NOD26; DLNB26; CLR11.3
UniProt Protein Name
NLR family member X1
UniProt Synonym Protein Names
Caterpiller protein 11.3; CLR11.3; Nucleotide-binding oligomerization domain protein 26; Nucleotide-binding oligomerization domain protein 5; Nucleotide-binding oligomerization domain protein 9
Protein Family
NLR family
UniProt Gene Name
NLRX1
UniProt Synonym Gene Names
NOD26; NOD5; NOD9; CLR11.3
UniProt Entry Name
NLRX1_HUMAN
NCBI Protein Information
NLR family member X1; NLR family, X1; NOD-like receptor X1; caterpiller protein 11.3; nucleotide-binding oligomerization domain protein 5; nucleotide-binding oligomerization domain protein 9; nucleotide-binding oligomerization domain protein 26; nucleotide-binding oligomerization domain, leucine rich repeat containing X1

NCBI Summary for NLRX1

The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013]

UniProt Comments for NLRX1

NLRX1: Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF- Kappa-B and type 1 interferon signaling pathways, but enhances NF- Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313). Interacts with MAVS. Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji, and Jurkat cell lines. Belongs to the NLRP family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: mitochondrial outer membrane

Molecular Function: protein binding; ATP binding

Biological Process: viral reproduction; negative regulation of innate immune response; negative regulation of inflammatory response; negative regulation of interleukin-6 production; innate immune response; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of interferon type I production; negative regulation of interferon-beta production
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Research Articles on NLRX1

1. Together, these results suggest a novel mechanism for rhinovirus-induced epithelial barrier disruption involving NLRX-1 and mitochondrial reactive oxygen species generation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NLRX1 antibody

 Reference Product  PubMed Publications
 MAVS antibody  >13 publications with NLRX1 and MAVS
 DDX58 antibody  >5 publications with NLRX1 and DDX58
 TRAF6 antibody  >3 publications with NLRX1 and TRAF6
 IFIH1 antibody  >2 publications with NLRX1 and IFIH1

Pathways associated with anti-NLRX1 antibody

 Products by Pathway  Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Negative Regulators Of RIG-I/MDA5 Signaling Pathway antibodies  Negative Regulators Of RIG-I/MDA5 Signaling Pathway Diagram
 RIG-I-like Receptor Signaling Pathway antibodies  RIG-I-like Receptor Signaling Pathway Diagram
 RIG-I-like Receptor Signaling Pathway antibodies  RIG-I-like Receptor Signaling Pathway Diagram
 RIG-I/MDA5 Mediated Induction Of IFN-alpha/beta Pathways antibodies  RIG-I/MDA5 Mediated Induction Of IFN-alpha/beta Pathways Diagram

Diseases associated with anti-NLRX1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >17 publications with NLRX1 and Inflammation
 Necrosis Antibodies  >4 publications with NLRX1 and Necrosis
 Immune System Diseases Antibodies  >3 publications with NLRX1 and Immune System Diseases
 Atrophy Antibodies  >2 publications with NLRX1 and Atrophy
 Liver Diseases Antibodies  >2 publications with NLRX1 and Liver Diseases
 Hemorrhage Antibodies  >1 publications with NLRX1 and Hemorrhage
 Fatty Liver, Alcoholic Antibodies  >1 publications with NLRX1 and Fatty Liver, Alcoholic
 Fatty Liver Antibodies  >1 publications with NLRX1 and Fatty Liver
 Disease Models, Animal Antibodies  >1 publications with NLRX1 and Disease Models, Animal

Organs/Tissues associated with anti-NLRX1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with NLRX1 and Blood
 Kidney Antibodies  >4 publications with NLRX1 and Kidney
 Spleen Antibodies  >3 publications with NLRX1 and Spleen
 Intestine Antibodies  >3 publications with NLRX1 and Intestine
 Bone Antibodies  >1 publications with NLRX1 and Bone
 Stomach Antibodies  >1 publications with NLRX1 and Stomach
 Lung Antibodies  >1 publications with NLRX1 and Lung
 Eye Antibodies  >1 publications with NLRX1 and Eye
 Nerve Antibodies  >1 publications with NLRX1 and Nerve
 Bone Marrow Antibodies  >1 publications with NLRX1 and Bone Marrow
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