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ANAPC1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151492

APC1 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC1, also known as mitotic checkpoint regulator (MCPR), is a highly conserved component of… More details

$530 / 0.1 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
APC1 (ANAPC1), Polyclonal Antibody
Full Product Name
APC1 Antibody
Product Gene Name
anti-ANAPC1 antibody
Product Synonym Names
APC1; APC1; MCPR; TSG24; Anaphase-promoting complex subunit 1; Cyclosome subunit 1; APC1; anaphase promoting complex subunit 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
APC1 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
APC1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
APC1 peptide (MBS152126) is used for blocking the activity of APC1 antibody (MBS151492)
Molecular Weight
216,500 Da
OMIM
608473
3D Structure
ModBase 3D Structure for Q9H1A4
Conjugate
Unconjugated
Immunogen
APC1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human APC1.
Buffer
APC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-ANAPC1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ANAPC1 antibody
APC1 antibody can be used for detection of APC1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL.

Western Blot (WB) of anti-ANAPC1 antibody

Western blot analysis of APC1 in SK-N-SH cell lysate with APC1 antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-ANAPC1 Polyclonal Antibody – Cat# MBS151492

Immunohistochemistry (IHC) of anti-ANAPC1 antibody

Immunohistochemistry of APC1 in human brain tissue with APC1 antibody at 5 μg/mL.
Rabbit Anti-ANAPC1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS151492

Other Notes

Small volumes of anti-ANAPC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ANAPC1 purchase

MBS151492 is an antibody targeting ANAPC1. Also known as APC1 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ANAPC1. It may not necessarily be applicable to this product.

NCBI GI #
37537845
NCBI GeneID
64682
NCBI Accession #
Q9H1A4.1
UniProt Primary Accession #
Q9H1A4
UniProt Secondary Accession #
Q2M3H8; Q9BSE6; Q9H8D0
UniProt Related Accession #
Q9H1A4
NCBI Official Full Name
Anaphase-promoting complex subunit 1
NCBI Official Synonym Full Names
anaphase promoting complex subunit 1
NCBI Official Symbol
ANAPC1
NCBI Official Synonym Symbols
APC1; MCPR; TSG24
UniProt Protein Name
Anaphase-promoting complex subunit 1
UniProt Synonym Protein Names
Cyclosome subunit 1; Mitotic checkpoint regulator; Testis-specific gene 24 protein
UniProt Gene Name
ANAPC1
UniProt Synonym Gene Names
TSG24; APC1
UniProt Entry Name
APC1_HUMAN
NCBI Protein Information
anaphase-promoting complex subunit 1; cyclosome subunit 1; mitotic checkpoint regulator; testis-specific gene 24 protein; anaphase-promoting complex 1 (meiotic checkpoint regulator)

NCBI Summary for ANAPC1

This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011]

UniProt Comments for ANAPC1

APC1: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC1 family.

Protein type: Cell cycle regulation; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 2q12.1

Cellular Component: nucleoplasm; anaphase-promoting complex; cytosol

Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle
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Research Articles on ANAPC1

1. Data indicate that regulation of Rad17 turnover is through the Cdh1/anaphase-promoting complex pathway in breast cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ANAPC1 antibody

 Reference Product  PubMed Publications
 ANAPC2 antibody  >8 publications with ANAPC1 and ANAPC2
 CDC16 antibody  >6 publications with ANAPC1 and CDC16
 CDC23 antibody  >6 publications with ANAPC1 and CDC23
 ANAPC4 antibody  >6 publications with ANAPC1 and ANAPC4
 CDC27 antibody  >6 publications with ANAPC1 and CDC27
 ANAPC5 antibody  >5 publications with ANAPC1 and ANAPC5
 ANAPC7 antibody  >3 publications with ANAPC1 and ANAPC7
 CDC20 antibody  >3 publications with ANAPC1 and CDC20
 PTTG1 antibody  >1 publications with ANAPC1 and PTTG1
 CCNB1 antibody  >1 publications with ANAPC1 and CCNB1

Pathways associated with anti-ANAPC1 antibody

 Products by Pathway  Pathway Diagram
 APC-Cdc20 Mediated Degradation Of Nek2A Pathway antibodies  APC-Cdc20 Mediated Degradation Of Nek2A Pathway Diagram
 APC/C Complex Pathway antibodies  APC/C Complex Pathway Diagram
 APC/C Complex Pathway antibodies  APC/C Complex Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Cyclin B Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Cyclin B Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway antibodies  APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway Diagram
 Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram

Diseases associated with anti-ANAPC1 antibody

 Disease Name  Pubmed Publications
 Atrophy Antibodies  >1 publications with ANAPC1 and Atrophy
 Adenocarcinoma Antibodies  >1 publications with ANAPC1 and Adenocarcinoma
 Hyperplasia Antibodies  >1 publications with ANAPC1 and Hyperplasia

Organs/Tissues associated with anti-ANAPC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with ANAPC1 and Lung
 Skin Antibodies  >1 publications with ANAPC1 and Skin
 Kidney Antibodies  >1 publications with ANAPC1 and Kidney
 Uterus Antibodies  >1 publications with ANAPC1 and Uterus
 Stomach Antibodies  >1 publications with ANAPC1 and Stomach
 Intestine Antibodies  >1 publications with ANAPC1 and Intestine
 Brain Antibodies  >1 publications with ANAPC1 and Brain
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