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TNFRSF6B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151528

DcR3 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. Several novel members in the TNFR family including DR3, DR4, DR5, and DR6 were recently discovered and… More details

$530 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DcR3 (TNFRSF6B), Polyclonal Antibody
Full Product Name
DcR3 Antibody
Product Gene Name
Product Synonym Names
DcR3; M68; TR6; DCR3; M68E; DJ583P15.1.1; UNQ186/PRO212; Tumor necrosis factor receptor superfamily member 6B; Decoy receptor 3; DcR3; tumor necrosis factor receptor superfamily, member 6b, decoy
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
DcR3 Antibody is Ion exchange chromatography purified.
Preparation and Storage
DcR3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
DcR3 peptide (MBS152417) is used for blocking the activity of DcR3 antibody (MBS151528)
Molecular Weight
33 kDa
OMIM
603361
3D Structure
ModBase 3D Structure for O95407
Conjugate
Unconjugated
Immunogen
DcR3 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human DcR3 precursor.
Buffer
DcR3 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-TNFRSF6B antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-TNFRSF6B antibody
DcR3 antibody can be used for detection of DcR3 expression by Western blot 0.5 mug/mL. An approximately 33 kDa band can be detected. Antibody can also be used for immunohistochemistry starting at 1 mug/mL.

Western Blot (WB) of anti-TNFRSF6B antibody

Western blot analysis of DcR3 in human heart (H), brain (B), and kidney (K) tissue lysates with DcR3 antibody at 1:500 dilution.
Rabbit Anti-TNFRSF6B Polyclonal Antibody – Cat# MBS151528

Immunohistochemistry (IHC) of anti-TNFRSF6B antibody

Immunohistochemistry of DcR3 in human heart tissue with DcR3 antibody at 1 μg/mL.
Rabbit Anti-TNFRSF6B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS151528

Other Notes

Small volumes of anti-TNFRSF6B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFRSF6B purchase

MBS151528 is an antibody targeting TNFRSF6B. Also known as DcR3 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFRSF6B. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
NCBI Official Full Name
Homo sapiens decoy receptor 3 (DcR3) mRNA, complete cds
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 6b, decoy
NCBI Official Symbol
TNFRSF6B
NCBI Official Synonym Symbols
M68; TR6; DCR3; M68E; DJ583P15.1.1
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 6B
UniProt Synonym Protein Names
Decoy receptor 3; DcR3; Decoy receptor for Fas ligand; M68
UniProt Gene Name
TNFRSF6B
UniProt Synonym Gene Names
DCR3; TR6; DcR3
UniProt Entry Name
TNF6B_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 6B; decoy receptor 3; decoy receptor for Fas ligand

NCBI Summary for TNFRSF6B

This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]
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UniProt Comments for TNFRSF6B

TNFRSF6B: Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: extracellular space

Molecular Function: protein binding; receptor activity

Biological Process: apoptosis; negative regulation of apoptosis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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