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TNPO3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151541

TNPO3 Antibody: TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these… More details

$530 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TNPO3, Polyclonal Antibody
Full Product Name
TNPO3 Antibody
Product Gene Name
Product Synonym Names
TNPO3; IPO12; TRNSR; LGMD1F; MTR10A; TRN-SR; TRN-SR2; IPO12; Transportin-3; Importin-12; Imp12; transportin 3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
TNPO3 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
TNPO3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
TNPO3 peptide (MBS152371) is used for blocking the activity of TNPO3 antibody (MBS151541)
Molecular Weight
97,372 Da
OMIM
phenotype 610032
3D Structure
ModBase 3D Structure for Q9Y5L0
Conjugate
Unconjugated
Immunogen
TNPO3 antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human TNPO3.
Buffer
TNPO3 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-TNPO3 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-TNPO3 antibody
TNPO3 antibody can be used for detection of TNPO3 by Western blot at 1 - 2 mug/mL.

Western Blot (WB) of anti-TNPO3 antibody

Western blot analysis of TNPO3 in rat liver tissue lysate with TNPO3 antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-TNPO3 Polyclonal Antibody – Cat# MBS151541

Western Blot (WB) of anti-TNPO3 antibody

Western blot analysis of TNPO3 expression in Jurkat cell lysate with TNPO3 antibody at (A) 1 and (B) 2 μg/ml.
Rabbit Anti-TNPO3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS151541

Other Notes

Small volumes of anti-TNPO3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNPO3 purchase

MBS151541 is an antibody targeting TNPO3. Also known as TNPO3 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TNPO3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
transportin 3, isoform CRA_a
NCBI Official Synonym Full Names
transportin 3
NCBI Official Symbol
TNPO3
NCBI Official Synonym Symbols
IPO12; TRNSR; LGMD1F; MTR10A; TRN-SR; TRN-SR2
UniProt Protein Name
Transportin-3
UniProt Synonym Protein Names
Importin-12; Imp12; Transportin-SR; TRN-SR
Protein Family
UniProt Gene Name
TNPO3
UniProt Synonym Gene Names
IPO12; Imp12; TRN-SR
UniProt Entry Name
TNPO3_HUMAN
NCBI Protein Information
transportin-3; imp12; importin 12; transportin-SR; limb girdle muscular dystrophy 1F (autosomal dominant)

NCBI Summary for TNPO3

The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection, apparently through interaction with the HIV-1 capsid protein. Two transcript variants encoding different isoforms as well as a noncoding transcript have been found for this gene.[provided by RefSeq, Jul 2010]
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UniProt Comments for TNPO3

IPO3: Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizing phosphorylated RS domains. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear import; Receptor, misc.; Nuclear export; Karyopherin

Chromosomal Location of Human Ortholog: 7q32.1

Cellular Component: intracellular membrane-bound organelle; cytoplasm; nucleus

Molecular Function: protein binding; receptor activity

Biological Process: splicing factor protein import into nucleus

Disease: Muscular Dystrophy, Limb-girdle, Type 1f
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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