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EMX2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151542

EMX2 Antibody: EMX2, like its closely related homolog EMX1, is a homeobox transcription factor involved in specifying cell fates in the developing central nervous system and participates in the development of olfactory neurons. EMX2 is expressed in the dorsal… More details

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Product Overview

Online Datasheet in PDF
Product Name
EMX2, Polyclonal Antibody
Full Product Name
EMX2 Antibody
Product Gene Name
anti-EMX2 antibody
Product Synonym Names
EMX2; Homeobox protein EMX2; Empty spiracles homolog 2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human; Predicted Species reactivity based on immunogen sequence: Mouse: (100%), Bovine (100%)
Form/Format
Liquid
Purity/Purification
EMX2 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
At least two isoforms of EMX2 are known to exist; this antibody will detect both isoforms. EMX2 antibody is predicted to not cross-react with EMX1
Preparation and Storage
EMX2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
EMX2 peptide (MBS152065) is used for blocking the activity of EMX2 antibody (MBS151542)
Molecular Weight
18,518 Da
OMIM
phenotype 600035
3D Structure
ModBase 3D Structure for Q04743
Conjugate
Unconjugated
Immunogen
EMX2 antibody was raised against an 18 amino acid synthetic peptide near the center of human EMX2. The immunogen is located within amino acids 60-110 of EMX2.
Buffer
EMX2 Antibody is supplied in PBS containing 0.02% sodium azide.
Positive Control
MBS151589: Human Lung Tissue Lysate
MBS154259: Human Lung Tissue Slide
Applications Tested/Suitable for anti-EMX2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC-P), Immunofluorescence (IF)
Application Notes for anti-EMX2 antibody
EMX2 antibody can be used for detection of EMX2 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 ug/mL.

Optimal dilutions for each application to be determined by the researcher.

Western Blot (WB) of anti-EMX2 antibody

Western blot analysis of EMX2 in human lung tissue lysate with EMX2 antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-EMX2 Polyclonal Antibody – Cat# MBS151542

Immunohistochemistry (IHC) of anti-EMX2 antibody

Immunohistochemistry of EMX2 in human lung tissue with EMX2 antibody at 2.5 μg/mL.
Rabbit Anti-EMX2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS151542

Immunofluorescence (IF) of anti-EMX2 antibody

Immunofluorescence of EMX2 in human lung tissue with EMX2 antibody at 20 μg/mL.
Rabbit Anti-EMX2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS151542

Other Notes

Small volumes of anti-EMX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EMX2 purchase

MBS151542 is an antibody targeting EMX2. Also known as EMX2 Antibody. Reactive in Human; Predicted Species reactivity based on immunogen sequence: Mouse: (100%), Bovine (100%). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for EMX2. It may not necessarily be applicable to this product.

NCBI GI #
19862512
NCBI GeneID
2018
NCBI Accession #
Q04743.2
UniProt Primary Accession #
Q04743
UniProt Secondary Accession #
Q96NN8; Q9BQF4; G3V305
UniProt Related Accession #
Q04743
NCBI Official Full Name
Homeobox protein EMX2
NCBI Official Synonym Full Names
empty spiracles homeobox 2
NCBI Official Symbol
EMX2
UniProt Protein Name
Homeobox protein EMX2
UniProt Synonym Protein Names
Empty spiracles homolog 2; Empty spiracles-like protein 2
Protein Family
Homeobox protein
UniProt Gene Name
EMX2
UniProt Entry Name
EMX2_HUMAN
NCBI Protein Information
homeobox protein EMX2; empty spiracles homolog 2; empty spiracles-like protein 2

NCBI Summary for EMX2

This gene encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. Research on this gene in humans has focused on its expression in three tissues: dorsal telencephalon, olfactory neuroepithelium, and urogenetial system. It is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10. Alternative splicing results in multiple transcript variants encoding distinct proteins.[provided by RefSeq, Sep 2009]
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UniProt Comments for EMX2

EMX2: Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system. Defects in EMX2 are the cause of schizencephaly (SCHZC). Schizencephaly is an extremely rare human congenital disorder characterized by a full-thickness cleft within the cerebral hemispheres. These clefts are lined with gray matter and most commonly involve the parasylvian regions. Large portions of the cerebral hemispheres may be absent and replaced by cerebro- spinal fluid. Belongs to the EMX homeobox family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 10q26.1

Cellular Component: nucleus

Molecular Function: protein binding; sequence-specific DNA binding

Biological Process: forebrain cell migration; neuron differentiation; response to drug; anterior/posterior pattern formation; dentate gyrus development; regulation of transcription, DNA-dependent; cell proliferation in forebrain; cerebral cortex regionalization

Disease: Schizencephaly
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Research Articles on EMX2

1. downregulation of empty spiracles homeobox 2 (EMX2) was associated with tumor progression and may be a critical factor in the carcinogenesis and progression of endometrial cancer

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-EMX2 antibody

 Reference Product  PubMed Publications
 SHH antibody  >10 publications with EMX2 and SHH
 PAX2 antibody  >5 publications with EMX2 and PAX2
 FOXG1 antibody  >5 publications with EMX2 and FOXG1
 TBR1 antibody  >4 publications with EMX2 and TBR1
 EGFR antibody  >3 publications with EMX2 and EGFR
 WNT7B antibody  >2 publications with EMX2 and WNT7B
 GFRA1 antibody  >2 publications with EMX2 and GFRA1
 WNT2B antibody  >1 publications with EMX2 and WNT2B
 WNT3A antibody  >1 publications with EMX2 and WNT3A
 EIF4E antibody  >1 publications with EMX2 and EIF4E

Diseases associated with anti-EMX2 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >26 publications with EMX2 and Nervous System Diseases
 Brain Diseases Antibodies  >13 publications with EMX2 and Brain Diseases
 Familial schizencephaly Antibodies  >11 publications with EMX2 and Familial schizencephaly
 Female Urogenital Diseases Antibodies  >11 publications with EMX2 and Female Urogenital Diseases
 Carcinoma Antibodies  >5 publications with EMX2 and Carcinoma
 Abnormalities, Drug-Induced Antibodies  >3 publications with EMX2 and Abnormalities, Drug-Induced
 Eye Diseases Antibodies  >3 publications with EMX2 and Eye Diseases
 Neurobehavioral Manifestations Antibodies  >3 publications with EMX2 and Neurobehavioral Manifestations
 Adenocarcinoma Antibodies  >3 publications with EMX2 and Adenocarcinoma
 Lung Neoplasms Antibodies  >3 publications with EMX2 and Lung Neoplasms

Organs/Tissues associated with anti-EMX2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >136 publications with EMX2 and Brain
 Embryonic Tissue Antibodies  >35 publications with EMX2 and Embryonic Tissue
 Eye Antibodies  >24 publications with EMX2 and Eye
 Uterus Antibodies  >14 publications with EMX2 and Uterus
 Kidney Antibodies  >10 publications with EMX2 and Kidney
 Ovary Antibodies  >7 publications with EMX2 and Ovary
 Muscle Antibodies  >6 publications with EMX2 and Muscle
 Heart Antibodies  >3 publications with EMX2 and Heart
 Uncharacterized Tissue Antibodies  >1 publications with EMX2 and Uncharacterized Tissue
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