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NLRC5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS151554

NOD4 Antibody: NOD4 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD4 contains a CARD-like domain, a central NOD domain and a large LRR region. NOD4, an… More details

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Product Overview

Online Datasheet in PDF
Product Name
NOD4 (NLRC5), Polyclonal Antibody
Full Product Name
NOD4 Antibody
Product Gene Name
anti-NLRC5 antibody
Product Synonym Names
NOD4; NOD4; NOD27; CLR16.1; NOD4; Protein NLRC5; Nucleotide-binding oligomerization domain protein 27; NLR family, CARD domain containing 5
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
NOD4 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
NOD4 antibody is predicted to not cross-react with other members of the NOD family of proteins.
Preparation and Storage
NOD4 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody/Peptide Pairs
NOD4 peptide (MBS153147) is used for blocking the activity of NOD4 antibody (MBS151554)
Molecular Weight
205 kDa
OMIM
613537
3D Structure
ModBase 3D Structure for Q86WI3
Conjugate
Unconjugated
Immunogen
NOD4 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human NOD4.
Buffer
NOD4 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-NLRC5 antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-NLRC5 antibody
NOD4 antibody can be used for detection of NOD4 by Western blot at 1 mug/mL. Antibody can also be used for immunocytochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-NLRC5 antibody

Western blot analysis of NOD4 in EL4 cell lysate with NOD4 antibody at 1 μg/mL.
Rabbit Anti-NLRC5 Polyclonal Antibody – Cat# MBS151554

Immunocytochemistry (IHC) of anti-NLRC5 antibody

Immunocytochemistry of NOD4 in HeLa cells with NOD4 antibody at 10 μg/mL.
Rabbit Anti-NLRC5 Polyclonal Antibody, Immunocytochemistry (IHC) – Cat# MBS151554

Immunofluorescence (IF) of anti-NLRC5 antibody

Immunofluorescence of NOD4 in HeLa cells with NOD4 antibody at 20 μg/mL.
Rabbit Anti-NLRC5 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS151554

Other Notes

Small volumes of anti-NLRC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NLRC5 purchase

MBS151554 is an antibody targeting NLRC5. Also known as NOD4 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NLRC5. It may not necessarily be applicable to this product.

NCBI GI #
116268109
NCBI GeneID
84166
NCBI Accession #
NP_115582
UniProt Primary Accession #
Q86WI3
UniProt Secondary Accession #
Q6P4A6; Q86VM7; Q8NF42; Q8TEE2; Q8TEJ1; Q969L7; B5MEF1; C9JMD8
UniProt Related Accession #
Q86WI3
GenBank Nucleotide #
NM_032206.3
NCBI Official Full Name
protein NLRC5
NCBI Official Synonym Full Names
NLR family, CARD domain containing 5
NCBI Official Symbol
NLRC5
NCBI Official Synonym Symbols
NOD4; NOD27; CLR16.1
UniProt Protein Name
Protein NLRC5
UniProt Synonym Protein Names
Caterpiller protein 16.1; CLR16.1; Nucleotide-binding oligomerization domain protein 27; Nucleotide-binding oligomerization domain protein 4
Protein Family
Protein
UniProt Gene Name
NLRC5
UniProt Synonym Gene Names
NOD27; NOD4; CLR16.1
UniProt Entry Name
NLRC5_HUMAN
NCBI Protein Information
protein NLRC5; NOD-like receptor C5; caterpiller protein 16.1; nucleotide-binding oligomerization domains 27; nucleotide-binding oligomerization domain protein 4; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5

NCBI Summary for NLRC5

This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]

UniProt Comments for NLRC5

NLRC5: Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. Belongs to the NLRP family. 6 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: cytoplasm; nucleus; cytosol

Molecular Function: protein binding; ATP binding

Biological Process: regulation of kinase activity; inhibition of NF-kappaB transcription factor; innate immune response; positive regulation of MHC class I biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; defense response to virus; negative regulation of interferon type I production
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Research Articles on NLRC5

1. This study presents a detailed functional study of the domains of NLRC5 revealing that the N-terminal domain of human NLRC5 has intrinsic transcriptional activity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-NLRC5 antibody

 Products by Pathway  Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Negative Regulators Of RIG-I/MDA5 Signaling Pathway antibodies  Negative Regulators Of RIG-I/MDA5 Signaling Pathway Diagram
 RIG-I/MDA5 Mediated Induction Of IFN-alpha/beta Pathways antibodies  RIG-I/MDA5 Mediated Induction Of IFN-alpha/beta Pathways Diagram

Diseases associated with anti-NLRC5 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >10 publications with NLRC5 and Inflammation
 Neoplasms, Experimental Antibodies  >2 publications with NLRC5 and Neoplasms, Experimental
 Immune System Diseases Antibodies  >2 publications with NLRC5 and Immune System Diseases
 Disease Models, Animal Antibodies  >2 publications with NLRC5 and Disease Models, Animal
 Heart Diseases Antibodies  >1 publications with NLRC5 and Heart Diseases
 Hemorrhage Antibodies  >1 publications with NLRC5 and Hemorrhage
 Necrosis Antibodies  >1 publications with NLRC5 and Necrosis

Organs/Tissues associated with anti-NLRC5 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with NLRC5 and Blood
 Bone Antibodies  >3 publications with NLRC5 and Bone
 Bone Marrow Antibodies  >3 publications with NLRC5 and Bone Marrow
 Kidney Antibodies  >2 publications with NLRC5 and Kidney
 Spleen Antibodies  >2 publications with NLRC5 and Spleen
 Intestine Antibodies  >2 publications with NLRC5 and Intestine
 Lung Antibodies  >2 publications with NLRC5 and Lung
 Liver Antibodies  >1 publications with NLRC5 and Liver
 Heart Antibodies  >1 publications with NLRC5 and Heart
 Muscle Antibodies  >1 publications with NLRC5 and Muscle
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