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TESPA1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS153352

TESPA1 is a critical component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development (1). TESPA1 encodes a protein of 458 amino acids and is highly conserved among… More details

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Product Overview

Online Datasheet in PDF
Product Name
TESPA1, Polyclonal Antibody
Full Product Name
TESPA1 Antibody
Product Gene Name
Product Synonym Names
TESPA1; HSPC257; KIAA0748; HSPC257; Protein TESPA1; Thymocyte-expressed positive selection-associated protein 1; thymocyte expressed, positive selection associated 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid ; TESPA1 antibody is supplied in PBS containing 0.02% sodium azide.
Purity/Purification
TESPA1 antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
TESPA1 antibody is human specific. At least three isoforms TESPA1 are known to exist.
Preparation and Storage
TESPA1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Antibody/Peptide Pairs
TESPA1 peptide (MBS153811) is used for blocking the activity of TESPA1 antibody (MBS153352)
Molecular Weight
Predicted: 57 kDa

Observed: 60 kDa
OMIM
615664
3D Structure
ModBase 3D Structure for A2RU30
Immunogen
TESPA1 antibody was raised against an 18 amino acid peptide near the amino terminus of human TESPA1.
The immunogen is located within amino acids 20 - 70 of TESPA1.
Applications Tested/Suitable for anti-TESPA1 antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-TESPA1 antibody
Optimal dilutions for each application to be determined by the researcher.

Western Blot (WB) of anti-TESPA1 antibody

Western blot analysis of TESPA1 in A431 cell lysate with TESPA1 antibody at 1 μg/ml.
Rabbit Anti-TESPA1 Polyclonal Antibody – Cat# MBS153352

Immunocytochemistry (IHC) of anti-TESPA1 antibody

Immunocytochemistry of TESPA1 in A431 cells with TESPA1 antibody at 5 μg/mL.
Rabbit Anti-TESPA1 Polyclonal Antibody, Immunocytochemistry (IHC) – Cat# MBS153352

Immunofluorescence (IF) of anti-TESPA1 antibody

Immunofluorescence of TESPA1 in A431 cells with TESPA1 antibody at 20 μg/mL.
Rabbit Anti-TESPA1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS153352

Other Notes

Small volumes of anti-TESPA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TESPA1 purchase

MBS153352 is an antibody targeting TESPA1. Also known as TESPA1 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TESPA1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
protein TESPA1 isoform 1
NCBI Official Synonym Full Names
thymocyte expressed, positive selection associated 1
NCBI Official Symbol
TESPA1
NCBI Official Synonym Symbols
HSPC257; KIAA0748
UniProt Protein Name
Protein TESPA1
UniProt Synonym Protein Names
Thymocyte-expressed positive selection-associated protein 1
Protein Family
UniProt Gene Name
TESPA1
UniProt Synonym Gene Names
KIAA0748
UniProt Entry Name
TESP1_HUMAN
NCBI Protein Information
protein TESPA1; thymocyte-expressed positive selection-associated protein 1

UniProt Comments for TESPA1

TESPA1: Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development. Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 12q13.2

Cellular Component: signalosome; endoplasmic reticulum membrane; cytoplasm

Molecular Function: receptor binding

Biological Process: positive regulation of T cell differentiation in the thymus; positive regulation of T cell receptor signaling pathway; signalosome assembly
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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