PPARGC1A Antibody – Rabbit Polyclonal

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]

PGC-1 alpha: a transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor genes. Interacts with, and regulates the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). Regulates many genes involved in energy metabolism. Provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. May be involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. Its transcription is repressed by ZNF746 which binds to 'insulin response sequences' in its promoter. Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 4p15.1

Cellular Component: nucleoplasm; PML body; DNA-directed RNA polymerase II, core complex; cytosol; nucleus

Molecular Function: ligand-dependent nuclear receptor binding; protein binding; androgen receptor binding; DNA binding; ligand-dependent nuclear receptor transcription coactivator activity; chromatin DNA binding; sequence-specific DNA binding; RNA binding; ubiquitin protein ligase binding; transcription coactivator activity; nucleotide binding; transcription factor binding

Biological Process: circadian rhythm; response to muscle activity; positive regulation of transcription, DNA-dependent; positive regulation of smooth muscle cell proliferation; thermoregulation; positive regulation of gluconeogenesis; regulation of transcription, DNA-dependent; flavone metabolic process; protein complex assembly; circadian regulation of gene expression; negative regulation of neuron apoptosis; negative regulation of glycolysis; mitochondrion organization and biogenesis; transcription initiation from RNA polymerase II promoter; protein stabilization; organelle organization and biogenesis; RNA splicing; androgen metabolic process; cellular respiration; regulation of circadian rhythm; gluconeogenesis; response to starvation; response to leucine; positive regulation of fatty acid oxidation; digestion; androgen receptor signaling pathway; galactose metabolic process; brown fat cell differentiation; cell glucose homeostasis; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of histone acetylation; fatty acid oxidation; response to cold; mRNA processing