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NCBP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS153370

NCBP1 Antibody: NCBP1, also known as CBP80, is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. NCBP1 promotes high-affinity mRNA-cap binding and associates with the… More details

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Product Overview

Online Datasheet in PDF
Product Name
NCBP1, Polyclonal Antibody
Full Product Name
NCBP1 Antibody
Product Gene Name
anti-NCBP1 antibody
Product Synonym Names
NCBP1; NCBP; Sto1; CBP80; NCBP; Nuclear cap-binding protein subunit 1; 80 kDa nuclear cap-binding protein; nuclear cap binding protein subunit 1, 80kDa
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
NCBP1 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
NCBP1 antibody is human, mouse and rat reactive. At least two isoforms of NCBP1 are known to exist; this antibody will detect both isoforms of NCBP1.
Preparation and Storage
NCBP1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
Antibody/Peptide Pairs
NCBP1 peptide (MBS153979) is used for blocking the activity of NCBP1 antibody (MBS153370)
Molecular Weight
Predicted: 87 kDa

Observed: 87 kDa
OMIM
600469
3D Structure
ModBase 3D Structure for Q09161
Conjugate
Unconjugated
Immunogen
NCBP1 antibody was raised against a 17 amino acid peptide near the center of human NCBP1.
Buffer
NCBP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-NCBP1 antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)
Application Notes for anti-NCBP1 antibody
NCBP1 antibody can be used for detection of NCBP1 by Western blot at 1 - 2 mug/mL.

Western Blot (WB) of anti-NCBP1 antibody

Western blot analysis of NCBP1 in HeLa cell lysate with NCBP1 antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-NCBP1 Polyclonal Antibody – Cat# MBS153370

Immunocytochemistry (IHC) of anti-NCBP1 antibody

Immunocytochemistry of NCBP1 in HeLa cells with NCBP1 antibody at 2.5 μg/ml.
Rabbit Anti-NCBP1 Polyclonal Antibody, Immunocytochemistry (IHC) – Cat# MBS153370

Other Notes

Small volumes of anti-NCBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NCBP1 purchase

MBS153370 is an antibody targeting NCBP1. Also known as NCBP1 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NCBP1. It may not necessarily be applicable to this product.

NCBI GI #
4505343
NCBI GeneID
4686
NCBI Accession #
NP_002477
UniProt Primary Accession #
Q09161
UniProt Secondary Accession #
Q59G76; Q5T1V0; Q5T7X2; B2R718
UniProt Related Accession #
Q09161
GenBank Nucleotide #
NM_002486.4
NCBI Official Full Name
nuclear cap-binding protein subunit 1
NCBI Official Synonym Full Names
nuclear cap binding protein subunit 1, 80kDa
NCBI Official Symbol
NCBP1
NCBI Official Synonym Symbols
NCBP; Sto1; CBP80
UniProt Protein Name
Nuclear cap-binding protein subunit 1
UniProt Synonym Protein Names
80 kDa nuclear cap-binding protein; CBP80; NCBP 80 kDa subunit
UniProt Gene Name
NCBP1
UniProt Synonym Gene Names
CBP80; NCBP; CBP80; NCBP 80 kDa subunit
UniProt Entry Name
NCBP1_HUMAN
NCBI Protein Information
nuclear cap-binding protein subunit 1; NCBP 80 kDa subunit; 80 kDa nuclear cap-binding protein; nuclear cap binding protein subunit 1, 80kD

NCBI Summary for NCBP1

The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein promotes high-affinity mRNA-cap binding and associates with the CTD of RNA polymerase II. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. [provided by RefSeq, Jul 2008]
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UniProt Comments for NCBP1

NCBP1: mediates U snRNA export from the nucleus. Binds to 5' capped mRNA. Found in aU snRNA export complex with RNUXA/PHAX, CBP20, CBP80, RAN, XPO1 and m7G-capped RNA. Interaction with RNUXA/PHAX. Heterodimer with NCBP2. Is part of the exon junction complex (EJC) containing NCBP1, NCBP2, RNPS1, RBM8A, SRRM1, NXF1, UPF3B, UPF2, THOC4 and/or REFBP2.

Protein type: Translation; RNA processing; Spliceosome

Chromosomal Location of Human Ortholog: 9q34.1

Cellular Component: nucleoplasm; mRNA cap complex; mitochondrion; cytoplasm; cytosol; nucleus; ribonucleoprotein complex

Molecular Function: protein binding; RNA binding; RNA cap binding

Biological Process: transcription from RNA polymerase II promoter; spliceosomal snRNP biogenesis; viral reproduction; positive regulation of viral transcription; RNA splicing; positive regulation of mRNA 3'-end processing; histone mRNA metabolic process; nuclear mRNA splicing, via spliceosome; mRNA export from nucleus; mRNA capping; RNA elongation from RNA polymerase II promoter; mRNA catabolic process, nonsense-mediated decay; nuclear mRNA cis splicing, via U2-type spliceosome; RNA-mediated gene silencing; gene expression; mRNA 3'-end processing; termination of RNA polymerase II transcription; mRNA cleavage; regulation of translational initiation
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Research Articles on NCBP1

1. down-regulation of CTIF using a small interfering RNA causes a redistribution of CBP80 from polysome fractions to subpolysome fractions, without significant consequence to eIF4E distribution

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NCBP1 antibody

 Reference Product  PubMed Publications
 EIF4E antibody  >1 publications with NCBP1 and EIF4E

Pathways associated with anti-NCBP1 antibody

 Products by Pathway  Pathway Diagram
 Abortive Elongation Of HIV-1 Transcript In The Absence Of Tat Pathway antibodies  Abortive Elongation Of HIV-1 Transcript In The Absence Of Tat Pathway Diagram
 Cap Binding Complex Pathway antibodies  Cap Binding Complex Pathway Diagram
 Cap Binding Complex Pathway antibodies  Cap Binding Complex Pathway Diagram
 Cleavage Of Growing Transcript In The Termination Region Pathway antibodies  Cleavage Of Growing Transcript In The Termination Region Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Formation Of HIV Elongation Complex In The Absence Of HIV Tat Pathway antibodies  Formation Of HIV Elongation Complex In The Absence Of HIV Tat Pathway Diagram
 Formation Of HIV-1 Elongation Complex Containing HIV-1 Tat Pathway antibodies  Formation Of HIV-1 Elongation Complex Containing HIV-1 Tat Pathway Diagram
 Formation Of RNA Pol II Elongation Complex Pathway antibodies  Formation Of RNA Pol II Elongation Complex Pathway Diagram
 Formation Of The Early Elongation Complex Pathway antibodies  Formation Of The Early Elongation Complex Pathway Diagram
 Formation Of The HIV-1 Early Elongation Complex Pathway antibodies  Formation Of The HIV-1 Early Elongation Complex Pathway Diagram

Diseases associated with anti-NCBP1 antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >1 publications with NCBP1 and Heart Diseases

Organs/Tissues associated with anti-NCBP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >1 publications with NCBP1 and Heart
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