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CRB2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS153375

CRB2 Antibody: CRB2 (Crumbs homolog 2), like its homologs CRB1 and CRB3, is similar to the Drosophila crumbs protein and is expressed in retina, brain and kidney. Along with other proteins, the Crumbs proteins form a complex that help set up cell polarity in… More details

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Product Overview

Online Datasheet in PDF
Product Name
CRB2, Polyclonal Antibody
Full Product Name
CRB2 Antibody
Product Gene Name
Product Synonym Names
CRB2; Protein crumbs homolog 2; Crumbs-like protein 2; crumbs homolog 2 (Drosophila)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
CRB2 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
At least three isoforms of CRB2 are known to exist; this antibody will detect all three. CRB2 antibody is predicted to not cross-react with other members of the CRB family.
Preparation and Storage
CRB2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
Antibody/Peptide Pairs
CRB2 peptide (MBS153913) is used for blocking the activity of CRB2 antibody (MBS153375)
Molecular Weight
Predicted: 141 kDa
OMIM
609720
3D Structure
ModBase 3D Structure for Q5IJ48
Conjugate
Unconjugated
Immunogen
Rabbit polyclonal CRB2 antibody was raised against a 17 amino acid peptide near the center of human CRB2.
Buffer
CRB2 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-CRB2 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-CRB2 antibody
CRB2 antibody can be used for detection of CRB2 by Western blot at 1 - 2 mug/mL.

Western Blot (WB) of anti-CRB2 antibody

Western blot analysis of CRB2 in rat brain tissue lysate with CRB2 antibody at (A) 0.5 and (B) 1 μg/mL
Rabbit Anti-CRB2 Polyclonal Antibody – Cat# MBS153375

Other Notes

Small volumes of anti-CRB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CRB2 purchase

MBS153375 is an antibody targeting CRB2. Also known as CRB2 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CRB2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
protein crumbs homolog 2
NCBI Official Synonym Full Names
crumbs family member 2
NCBI Official Symbol
CRB2
UniProt Protein Name
Protein crumbs homolog 2
UniProt Synonym Protein Names
Crumbs-like protein 2
Protein Family
UniProt Gene Name
CRB2
UniProt Entry Name
CRUM2_HUMAN
NCBI Protein Information
protein crumbs homolog 2; crumbs-like protein 2

UniProt Comments for CRB2

CRB2: May play a role in polarized cells morphogenesis. Belongs to the Crumbs protein family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q33.3

Cellular Component: protein complex; plasma membrane; integral to membrane; lipid raft

Molecular Function: enzyme binding; aspartic-type endopeptidase inhibitor activity; calcium ion binding

Biological Process: somitogenesis; mesoderm formation; notochord formation; maintenance of epithelial cell polarity; positive regulation of BMP signaling pathway

Disease: Ventriculomegaly With Cystic Kidney Disease; Focal Segmental Glomerulosclerosis 9
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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