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PHC3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS153385

Polycomb group (PcG) proteins assemble into multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes throughout development (1). PHC3 (Polyhomeotic-like protein 3), also known as Early development… More details

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Product Overview

Online Datasheet in PDF
Product Name
PHC3, Polyclonal Antibody
Full Product Name
PHC3 Antibody
Product Gene Name
Product Synonym Names
PHC3; EDR3; HPH3; EDR3; PH3; Polyhomeotic-like protein 3; Early development regulatory protein 3; hPH3; polyhomeotic homolog 3 (Drosophila)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
PHC3 antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
PHC3 antibody is human, mouse and rat specific. At least six isoforms of PHC3 are known to exist.
Preparation and Storage
PHC3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
Antibody/Peptide Pairs
PHC3 peptide (MBS153964) is used for blocking the activity of PHC3 antibody (MBS153385)
Molecular Weight
Predicted: 109 kDa

Observed: 120 kDa
3D Structure
ModBase 3D Structure for Q8NDX5
Conjugate
Unconjugated
Immunogen
PHC3 antibody was raised against a 19 amino acid peptide near the amino terminus of human PHC3.
Buffer
PHC3 antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-PHC3 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-PHC3 antibody
PHC3 antibody can be used for detection of PHC3 by Western blot at 1 - 2 mug/ml.

Western Blot (WB) of anti-PHC3 antibody

Western blot analysis of PHC3 in 3T3 cell lysate with PHC3 antibody at (A) 1 and (B) 2 μg/ml.
Rabbit Anti-PHC3 Polyclonal Antibody – Cat# MBS153385

Other Notes

Small volumes of anti-PHC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PHC3 purchase

MBS153385 is an antibody targeting PHC3. Also known as PHC3 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PHC3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
polyhomeotic-like protein 3
NCBI Official Synonym Full Names
polyhomeotic homolog 3 (Drosophila)
NCBI Official Symbol
PHC3
NCBI Official Synonym Symbols
EDR3; HPH3
UniProt Protein Name
Polyhomeotic-like protein 3
UniProt Synonym Protein Names
Early development regulatory protein 3; Homolog of polyhomeotic 3; hPH3
UniProt Gene Name
PHC3
UniProt Synonym Gene Names
EDR3; PH3; hPH3
UniProt Entry Name
PHC3_HUMAN
NCBI Protein Information
polyhomeotic-like protein 3; polyhomeotic like 3; homolog of polyhomeotic 3; early development regulator 3; early development regulatory protein 3

UniProt Comments for PHC3

PHC3: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription regulation

Chromosomal Location of Human Ortholog: 3q26.2

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; PcG protein complex; nucleus; actin cytoskeleton

Molecular Function: DNA binding; zinc ion binding

Biological Process: multicellular organismal development
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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