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SUZ12 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS153413

The Polycomb group (PcG) genes contribute to the maintenance of cell identity, cell cycle regulation and oncogenesis (1). SUZ12 (suppressor of zeste 12) is a 90 - 95 kDa member of the polycomb group of transcriptional regulators (2). It is part of a… More details

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Product Overview

Online Datasheet in PDF
Product Name
SUZ12, Polyclonal Antibody
Full Product Name
SUZ12 Antibody
Product Gene Name
anti-SUZ12 antibody
Product Synonym Names
SUZ12; CHET9; JJAZ1; CHET9; KIAA0160; Polycomb protein SUZ12; Chromatin precipitated E2F target 9 protein; ChET 9 protein; SUZ12 polycomb repressive complex 2 subunit
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
SUZ12 antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
SUZ12 antibody is human specific.
Preparation and Storage
SUZ12 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
Antibody/Peptide Pairs
SUZ12 peptide (MBS154034) is used for blocking the activity of SUZ12 antibody (MBS153413)
Molecular Weight
Predicted: 81 kDa

Observed: 96 kDa
OMIM
606245
3D Structure
ModBase 3D Structure for Q15022
Conjugate
Unconjugated
Immunogen
SUZ12 antibody was raised against a 19 amino acid peptide near the center of human SUZ12.
Buffer
SUZ12 antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-SUZ12 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-SUZ12 antibody
SUZ12 antibody can be used for detection of SUZ12 by Western blot at 1 - 2 mug/ml. Antibody can also be used for Immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-SUZ12 antibody

Western blot analysis of SUZ12 in human liver tissue lysate with SUZ12 antibody at 1 μg/ml.
Rabbit Anti-SUZ12 Polyclonal Antibody – Cat# MBS153413

Immunohistochemistry (IHC) of anti-SUZ12 antibody

Immunohistochemistry of SUZ12 in human lung tissue with SUZ12 antibody at 5 μg/mL.
Rabbit Anti-SUZ12 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS153413

Immunofluorescence (IF) of anti-SUZ12 antibody

Immunofluorescence of SUZ12 in human lung tissue with SUZ12 antibody at 20 μg/mL.
Rabbit Anti-SUZ12 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS153413

Other Notes

Small volumes of anti-SUZ12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SUZ12 purchase

MBS153413 is an antibody targeting SUZ12. Also known as SUZ12 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SUZ12. It may not necessarily be applicable to this product.

NCBI GI #
197333809
NCBI GeneID
23512
NCBI Accession #
NP_056170
UniProt Primary Accession #
Q15022
UniProt Secondary Accession #
Q96BD9
UniProt Related Accession #
Q15022
GenBank Nucleotide #
NM_015355.2
NCBI Official Full Name
polycomb protein SUZ12
NCBI Official Synonym Full Names
SUZ12 polycomb repressive complex 2 subunit
NCBI Official Symbol
SUZ12
NCBI Official Synonym Symbols
CHET9; JJAZ1
UniProt Protein Name
Polycomb protein SUZ12
UniProt Synonym Protein Names
Chromatin precipitated E2F target 9 protein; ChET 9 protein; Joined to JAZF1 protein; Suppressor of zeste 12 protein homolog
Protein Family
Polycomb protein
UniProt Gene Name
SUZ12
UniProt Synonym Gene Names
CHET9; JJAZ1; KIAA0160; ChET 9 protein
UniProt Entry Name
SUZ12_HUMAN
NCBI Protein Information
polycomb protein SUZ12; chET 9 protein; joined to JAZF1 protein; suppressor of zeste 12 homolog; suppressor of zeste 12 protein homolog; chromatin precipitated E2F target 9 protein

NCBI Summary for SUZ12

This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]
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UniProt Comments for SUZ12

SUZ12: a zinc finger protein. A breakpoint translocation of the cognate gene with JAZF1 has been reported in endometrial stromal sarcoma.

Protein type: C2H2-type zinc finger protein; Transcription factor; Oncoprotein

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: nucleoplasm; sex chromatin; ESC/E(Z) complex; nucleolus; nucleus

Molecular Function: histone methyltransferase activity; protein binding; sequence-specific DNA binding; RNA binding; metal ion binding; chromatin binding; methylated histone residue binding

Biological Process: histone methylation; negative regulation of cell differentiation; transcription, DNA-dependent; negative regulation of gene expression, epigenetic; positive regulation of cell proliferation; histone ubiquitination; gene expression; negative regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic
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Research Articles on SUZ12

1. Somatic mutations of SUZ12 have a central role in malignant transformation of peripheral nerve sheath tumors.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SUZ12 antibody

 Reference Product  PubMed Publications
 EZH2 antibody  >124 publications with SUZ12 and EZH2
 EED antibody  >84 publications with SUZ12 and EED
 EZH1 antibody  >10 publications with SUZ12 and EZH1
 ASXL1 antibody  >5 publications with SUZ12 and ASXL1
 CTCF antibody  >5 publications with SUZ12 and CTCF
 AEBP2 antibody  >5 publications with SUZ12 and AEBP2
 RBBP4 antibody  >4 publications with SUZ12 and RBBP4
 HDAC2 antibody  >3 publications with SUZ12 and HDAC2
 RBBP7 antibody  >3 publications with SUZ12 and RBBP7

Pathways associated with anti-SUZ12 antibody

 Products by Pathway  Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Epigenetic Regulation Of Gene Expression Pathway antibodies  Epigenetic Regulation Of Gene Expression Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Oxidative Stress Induced Senescence Pathway antibodies  Oxidative Stress Induced Senescence Pathway Diagram
 PRC2 Methylates Histones And DNA Pathway antibodies  PRC2 Methylates Histones And DNA Pathway Diagram

Diseases associated with anti-SUZ12 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >16 publications with SUZ12 and Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >16 publications with SUZ12 and Cell Transformation, Neoplastic
 Endometrial Neoplasms Antibodies  >15 publications with SUZ12 and Endometrial Neoplasms
 Neoplasm Metastasis Antibodies  >14 publications with SUZ12 and Neoplasm Metastasis
 Lung Neoplasms Antibodies  >12 publications with SUZ12 and Lung Neoplasms
 Nerve Sheath Neoplasms Antibodies  >12 publications with SUZ12 and Nerve Sheath Neoplasms
 Prostatic Diseases Antibodies  >11 publications with SUZ12 and Prostatic Diseases
 Adenocarcinoma Antibodies  >9 publications with SUZ12 and Adenocarcinoma
 Congenital Abnormalities Antibodies  >6 publications with SUZ12 and Congenital Abnormalities
 Inflammation Antibodies  >5 publications with SUZ12 and Inflammation

Organs/Tissues associated with anti-SUZ12 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >21 publications with SUZ12 and Embryonic Tissue
 Blood Antibodies  >19 publications with SUZ12 and Blood
 Prostate Antibodies  >18 publications with SUZ12 and Prostate
 Brain Antibodies  >16 publications with SUZ12 and Brain
 Lung Antibodies  >13 publications with SUZ12 and Lung
 Bone Antibodies  >10 publications with SUZ12 and Bone
 Liver Antibodies  >9 publications with SUZ12 and Liver
 Muscle Antibodies  >7 publications with SUZ12 and Muscle
 Bone Marrow Antibodies  >7 publications with SUZ12 and Bone Marrow
 Lymph Antibodies  >6 publications with SUZ12 and Lymph
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