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SESTRIN2 (SESN2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS153416

SESTRIN2, also known as Hi95, is a member of the sestrin family of PA26-related proteins and is induced following DNA damage or oxidative stress (1). SESTRIN2 and the related protein SESTRIN1 interact with the NRF2 suppressor KEAP1, the autophagy substrate… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SESTRIN2 (SESN2), Polyclonal Antibody
Full Product Name
SESTRIN2 Antibody
Product Gene Name
Product Synonym Names
SESTRIN-2; SES2; SEST2; SESN2; HI95; sestrin 2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
SESTRIN2 antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
SESTRIN2 antibody is human, mouse and rat reactive. At least two isoforms of SESTRIN2 are known to exist; this antibody will detect both isoforms. SESTRIN2 antibody is predicted to not cross-react with SESTRIN1.
Preparation and Storage
SESTRIN2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
Antibody/Peptide Pairs
SESTRIN2 peptide (MBS154050) is used for blocking the activity of SESTRIN2 antibody (MBS153416)
Molecular Weight
Predicted: 54 kDa

Observed: 53 kDa
OMIM
607767
3D Structure
ModBase 3D Structure for P58004
Conjugate
Unconjugated
Immunogen
SESTRIN2 antibody was raised against a 19 amino acid peptide near the center of human SESTRIN2.
Buffer
SESTRIN2 antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-SESN2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-SESN2 antibody
SESTRIN2 antibody can be used for detection of SESTRIN2 by Western blot at 1 - 2 mug/ml. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-SESN2 antibody

Western blot analysis of SESTRIN2 in mouse kidney tissue lysate with SESTRIN2 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
Rabbit Anti-SESN2 Polyclonal Antibody – Cat# MBS153416

Immunohistochemistry (IHC) of anti-SESN2 antibody

Immunohistochemistry of SESTRIN2 in mouse kidney tissue with SESTRIN2 antibody at 5 μg/ml.
Rabbit Anti-SESN2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS153416

Immunofluorescence (IF) of anti-SESN2 antibody

Immunofluorescence of SESTRIN2 in mouse kidney tissue with SESTRIN2 antibody at 20 μg/ml.
Rabbit Anti-SESN2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS153416

Other Notes

Small volumes of anti-SESN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SESN2 purchase

MBS153416 is an antibody targeting SESN2. Also known as SESTRIN2 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SESN2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
sestrin-2
NCBI Official Synonym Full Names
sestrin 2
NCBI Official Symbol
SESN2
NCBI Official Synonym Symbols
HI95; SES2; SEST2
UniProt Protein Name
Sestrin-2
UniProt Synonym Protein Names
Hi95
Protein Family
UniProt Gene Name
SESN2
UniProt Synonym Gene Names
SEST2
UniProt Entry Name
SESN2_HUMAN
NCBI Protein Information
sestrin-2; hypoxia induced gene 95

NCBI Summary for SESN2

This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. [provided by RefSeq, Jul 2008]

UniProt Comments for SESN2

SESN2: Involved in the reduction of peroxiredoxins. Widely expressed. Belongs to the sestrin family.

Protein type: Enzyme, misc.

Chromosomal Location of Human Ortholog: 1p35.3

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: fatty acid beta-oxidation; glucose import; response to glucose stimulus; protein kinase B signaling cascade; autophagy; mitochondrial DNA metabolic process; response to insulin stimulus
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SESN2 antibody

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