Rabbit Anti-TSPY1 Polyclonal Antibody – Cat# MBS153456

Western blot analysis of TSPY1L in A20 cell lysate with TSPY1L antibody at (A) 0.5 and (B) 1 μg/mL

TSPY1L (TSPY1) Antibody – Rabbit Polyclonal

Name: TSPY1 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS153456
Price: 530 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS153456

TSPY1L Antibody: Testis-specific protein on Y chromosome (TSPY1) is an ampliconic gene on the Y chromosome that has been associated with gonadoblastoma. Recent experiments have shown that in androgen-dependent testicular germ-cell tumors, TSPY1 can repress… More details

$530 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TSPY1L, Polyclonal Antibody

Full Product Name

TSPY1L Antibody

Product Gene Name

anti-TSPY1 antibody

Product Synonym Names

TSPY1L; CT78; TSPY; DYS14; pJA923; Testis-specific Y-encoded protein 1; CT78; testis specific protein, Y-linked 1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Liquid

Purity/Purification

TSPY1L Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL (lot specific)

Specificity

TSPY1L antibody is human and mouse reactive. At least three isoforms of TSPY1 are known to exist; this antibody will detect only TSPY1L.

Preparation and Storage

TSPY1L antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Antibody/Peptide Pairs

TSPY1L peptide (MBS153814) is used for blocking the activity of TSPY1L antibody (MBS153456)

Molecular Weight

34 kDa

OMIM

480100

3D Structure

ModBase 3D Structure for Q01534

Conjugate

Unconjugated

Immunogen

Rabbit polyclonal TSPY1L antibody was raised against a 20 amino acid peptide near the carboxy terminus of human TSPY1L.

Buffer

TSPY1L Antibody is supplied in PBS containing 0.02% sodium azide.

Applications Tested/Suitable for anti-TSPY1 antibody

ELISA (EIA), Western Blot (WB)

Application Notes for anti-TSPY1 antibody

TSPY1L antibody can be used for detection of TSPY1L by Western blot at 0.5 - 1 mug/mL.

Other Notes

Small volumes of anti-TSPY1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TSPY1 purchase

MBS153456 is an antibody targeting TSPY1. Also known as TSPY1L Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TSPY1. It may not necessarily be applicable to this product.

NCBI GI #

139948460

NCBI GeneID

7258

NCBI Accession #

NP_003299

UniProt Primary Accession #

Q01534

UniProt Secondary Accession #

O00216; P09002; Q0VAD3; Q9UNN7; A6NJD2

UniProt Related Accession #

Q01534

GenBank Nucleotide #

NM_003308.3

NCBI Official Full Name

testis-specific Y-encoded protein 1 isoform TSPY-L

NCBI Official Synonym Full Names

testis specific protein, Y-linked 1

NCBI Official Symbol

TSPY1

NCBI Official Synonym Symbols

CT78; TSPY; DYS14; pJA923

UniProt Protein Name

Testis-specific Y-encoded protein 1

UniProt Synonym Protein Names

Cancer/testis antigen 78; CT78

Protein Family

Testis-specific Y-encoded protein

UniProt Gene Name

TSPY1

UniProt Synonym Gene Names

TSPY; CT78

UniProt Entry Name

TSPY1_HUMAN

NCBI Protein Information

testis-specific Y-encoded protein 1; cancer/testis antigen 78

NCBI Summary for TSPY1

The protein encoded by this gene is found only in testicular tissue and may be involved in spermatogenesis. Approximately 35 copies of this gene are present in humans, but only a single, nonfunctional orthologous gene is found in mouse. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

UniProt Comments for TSPY1

TSPY1: May be involved in sperm differentiation and proliferation. TSPY is located in the gonadoblastoma critical region and is preferentially expressed in tumor germ cells of gonadoblastoma specimens. Expression also correlates with testicular seminoma and tumorigenesis of the prostate gland. Belongs to the nucleosome assembly protein (NAP) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: Yp11.2

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: cell proliferation; nucleosome assembly; gonadal mesoderm development; spermatogenesis; cell differentiation; sex differentiation

Disease: Gonadoblastoma

Research Articles on TSPY1

1. The oncogenic events leading to an ectopic activation of TSPY and/or inactivating mutation/epigenetic silencing of TSPX could collectively contribute to the sexual dimorphism(s) in HCC and related liver cancers in male-biased manners.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TSPY1 antibody

Reference Product	PubMed Publications
AMELY antibody	>4 publications with TSPY1 and AMELY
PRKY antibody	>3 publications with TSPY1 and PRKY
PCDH11Y antibody	>1 publications with TSPY1 and PCDH11Y
TBL1Y antibody	>1 publications with TSPY1 and TBL1Y

Organs/Tissues associated with anti-TSPY1 antibody

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>61 publications with TSPY1 and Testis
Mixed Antibodies	>2 publications with TSPY1 and Mixed