TYK2 Antibody – Rabbit Polyclonal

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]

Tyk2: a non-receptor tyrosine-protein kinase of the JakA family. Activated in signaling from the IL-2, gp130 and IFN families of receptors. Phosphorylates the interferon-alpha/beta receptor alpha chain.

Protein type: Kinase, protein; EC 2.7.10.2; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; JakA family

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: extrinsic to internal side of plasma membrane; cytoskeleton; cytoplasm; cytosol; nucleus

Molecular Function: protein binding; growth hormone receptor binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; type 1 angiotensin receptor binding; ATP binding

Biological Process: cell migration; cytokine and chemokine mediated signaling pathway; innate immune response; cell differentiation; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation

Disease: Immunodeficiency 35