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KREMEN2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS153545

KREMEN2 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a… More details

$530 / 0.1 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
KREMEN2, Polyclonal Antibody
Full Product Name
KREMEN2 Antibody
Product Gene Name
Product Synonym Names
KREMEN2; KRM2; KRM2; Kremen protein 2; Dickkopf receptor 2; kringle containing transmembrane protein 2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
KREMEN2 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
Multiple isoforms of KREMEN2 are known to exist. KREMEN2 antibody is predicted to not cross-react with other Kremen protein family members.
Preparation and Storage
KREMEN2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
Antibody/Peptide Pairs
KREMEN2 peptide (MBS153815) is used for blocking the activity of KREMEN2 antibody (MBS153545)
Molecular Weight
Predicted: 51 kDa

Observed: 54 kDa
OMIM
609899
3D Structure
ModBase 3D Structure for Q8NCW0
Conjugate
Unconjugated
Immunogen
KREMEN2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human KREMEN2.
Buffer
KREMEN2 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-KREMEN2 antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)
Application Notes for anti-KREMEN2 antibody
KREMEN2 Antibody can be used for detection of KREMEN2 by Western blot starting at 1 mug/mL.

Western Blot (WB) of anti-KREMEN2 antibody

Western blot analysis of KREMEN2 in HeLa cell lysate with KREMEN2 antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-KREMEN2 Polyclonal Antibody – Cat# MBS153545

Immunocytochemistry (IHC) of anti-KREMEN2 antibody

Immunocytochemistry of KREMEN2 in HeLa cells with KREMEN2 antibody at 5 μg/ml.
Rabbit Anti-KREMEN2 Polyclonal Antibody, Immunocytochemistry (IHC) – Cat# MBS153545

Other Notes

Small volumes of anti-KREMEN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KREMEN2 purchase

MBS153545 is an antibody targeting KREMEN2. Also known as KREMEN2 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KREMEN2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
kremen protein 2 isoform d
NCBI Official Synonym Full Names
kringle containing transmembrane protein 2
NCBI Official Symbol
KREMEN2
NCBI Official Synonym Symbols
KRM2
UniProt Protein Name
Kremen protein 2
UniProt Synonym Protein Names
Dickkopf receptor 2; Kringle domain-containing transmembrane protein 2; Kringle-containing protein marking the eye and the nose
Protein Family
UniProt Gene Name
KREMEN2
UniProt Synonym Gene Names
KRM2
UniProt Entry Name
KREM2_HUMAN
NCBI Protein Information
kremen protein 2; dickkopf receptor 2; kringle domain-containing transmembrane protein 2; kringle-containing protein marking the eye and the nose

NCBI Summary for KREMEN2

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
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UniProt Comments for KREMEN2

KREMEN2: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: membrane; early endosome membrane; plasma membrane; integral to membrane

Biological Process: Wnt receptor signaling pathway; cell communication
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-KREMEN2 antibody

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