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NELF Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS153558

NELF Antibody: NELF (nasal embryonic luteinizing hormone-releasing hormone factor) is a 530 amino acid transcription factor involved in the migration of LHRH neurons, outgrowth of olfactory axons and suppression of transcription elongation. NELF is found in… More details

$530 / 0.1 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
NELF, Polyclonal Antibody
Full Product Name
NELF Antibody
Product Gene Name
anti-NELF antibody
Product Synonym Names
NELF; HH9; NELF; NMDA receptor synaptonuclear signaling and neuronal migration factor; Nasal embryonic luteinizing hormone-releasing hormone factor; Nasal embryonic LHRH factor; nasal embryonic LHRH factor
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
NELF Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Preparation and Storage
NELF antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
Antibody/Peptide Pairs
NELF peptide (MBS153850) is used for blocking the activity of NELF antibody (MBS153558)
Molecular Weight
Predicted: 58 kDa
OMIM
gene 614838
3D Structure
ModBase 3D Structure for Q6X4W1
Conjugate
Unconjugated
Immunogen
Rabbit polyclonal NELF antibody was raised against a 17 amino acid peptide near the center of human NELF.
Buffer
NELF Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-NELF antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-NELF antibody
NELF antibody can be used for detection of NELF by Western blot at 1 - 2 mug/mL.

Western Blot (WB) of anti-NELF antibody

Western blot analysis of NELF in Hela cell lysate with NELF antibody at (A) 1 and (B) 2 μg/mL.
Rabbit Anti-NELF Polyclonal Antibody – Cat# MBS153558

Immunohistochemistry (IHC) of anti-NELF antibody

Immunohistochemistry of NELF in rat brain tissue with NELF antibody at 2.5 μg/ml.
Rabbit Anti-NELF Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS153558

Immunofluorescence (IF) of anti-NELF antibody

Immunofluorescence of NELF in rat brain tissue with NELF antibody at 20 μg/ml.
Rabbit Anti-NELF Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS153558

Immunohistochemistry (IHC) of anti-NELF antibody

Immunohistochemistry of NELF in mouse brain tissue with NELF Antibody at 5 μg/mL.
Rabbit Anti-NELF Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS153558

Immunofluorescence (IF) of anti-NELF antibody

Immunofluorescence of NELF in mouse brain tissue with NELF Antibody at 20 μg/mL.

Green: NELF antibody (7225)
Red: Phylloidin staining
Blue: DAPI staining
Rabbit Anti-NELF Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS153558

Other Notes

Small volumes of anti-NELF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NELF purchase

MBS153558 is an antibody targeting NELF. Also known as NELF Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NELF. It may not necessarily be applicable to this product.

NCBI GI #
46397396
NCBI GeneID
26012
NCBI Accession #
NP_056352
UniProt Primary Accession #
Q6X4W1
UniProt Secondary Accession #
Q2TB96; Q6X4V7; Q6X4V8; Q6X4V9; Q8N2M2; Q96SY1; Q9NPM4; Q9NPP3; Q9NPS3
UniProt Related Accession #
Q6X4W1
GenBank Nucleotide #
NM_015537.4
NCBI Official Full Name
NMDA receptor synaptonuclear signaling and neuronal migration factor isoform b
NCBI Official Synonym Full Names
NMDA receptor synaptonuclear signaling and neuronal migration factor
NCBI Official Symbol
NSMF
NCBI Official Synonym Symbols
HH9; NELF
UniProt Protein Name
NMDA receptor synaptonuclear signaling and neuronal migration factor
UniProt Synonym Protein Names
Nasal embryonic luteinizing hormone-releasing hormone factor; Nasal embryonic LHRH factor
Protein Family
Negative elongation factor
UniProt Gene Name
NSMF
UniProt Synonym Gene Names
NELF; Nasal embryonic LHRH factor
UniProt Entry Name
NSMF_HUMAN
NCBI Protein Information
NMDA receptor synaptonuclear signaling and neuronal migration factor; nasal embryonic LHRH factor; nasal embryonic luteinizing hormone-releasing hormone factor

NCBI Summary for NELF

The protein encoded by this gene is involved in guidance of olfactory axon projections and migration of luteinizing hormone-releasing hormone neurons. Defects in this gene are a cause of idiopathic hypogonadotropic hypogonadism (IHH). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
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UniProt Comments for NELF

NSMF: Couples NMDA receptor signaling to the nucleus. Influences outgrowth of olfactory axons and migration of LHRH neurons. Defects in NELF may be associated with idiopathic hypogonadotropic hypogonadism (IHH). IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: cortical cytoskeleton; nuclear membrane; neuron projection; nuclear matrix; dendrite; postsynaptic density; nuclear envelope; perikaryon; nucleoplasm; postsynaptic membrane; membrane; cytoplasm; synapse; nucleus; cell junction

Molecular Function: calcium-dependent protein binding

Biological Process: regulation of dendrite morphogenesis; regulation of neuron apoptosis; positive regulation of protein amino acid dephosphorylation; regulation of neuronal synaptic plasticity

Disease: Hypogonadotropic Hypogonadism 9 With Or Without Anosmia
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Research Articles on NELF

1. The nuclear and non-nuclear NELF variant transcripts and proteins were identified, explaining variable NELF cellular localization.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-NELF antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >1 publications with NELF and Kidney Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with NELF and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >1 publications with NELF and Liver Diseases
 Liver Neoplasms Antibodies  >1 publications with NELF and Liver Neoplasms
 Carcinoma Antibodies  >1 publications with NELF and Carcinoma

Organs/Tissues associated with anti-NELF antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >2 publications with NELF and Eye
 Embryonic Tissue Antibodies  >2 publications with NELF and Embryonic Tissue
 Heart Antibodies  >2 publications with NELF and Heart
 Liver Antibodies  >1 publications with NELF and Liver
 Kidney Antibodies  >1 publications with NELF and Kidney
 Blood Antibodies  >1 publications with NELF and Blood
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