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AGR2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS153577

AGR2 Antibody: AGR2 (anterior gradient protein 2) and AGR3 are members of the anterior gradient homolog family. They are secreted cytoplasmic proteins which are involved in metastasis induction and p53 tumour supressor inhibition. They may serve as molecular… More details

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Product Overview

Online Datasheet in PDF
Product Name
AGR2, Polyclonal Antibody
Full Product Name
AGR2 Antibody
Product Gene Name
anti-AGR2 antibody
Product Synonym Names
AGR2; AG2; GOB-4; HAG-2; XAG-2; PDIA17; HEL-S-116; AG2; UNQ515/PRO1030; Anterior gradient protein 2 homolog; HPC8; AG-2; anterior gradient 2 homolog (Xenopus laevis)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
AGR2 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
Two isoforms of AGR2 exists as a result of alternative splicing event.
Preparation and Storage
AGR2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
Antibody/Peptide Pairs
AGR2 peptide (MBS154103) is used for blocking the activity of AGR2 antibody (MBS153577)
Molecular Weight
19 kDa
OMIM
606358
3D Structure
ModBase 3D Structure for O95994
Conjugate
Unconjugated
Immunogen
Rabbit polyclonal AGR2 antibody was raised against a 17 amino acid peptide near the amino terminus of human AGR2.
Buffer
AGR2 Antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-AGR2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-AGR2 antibody
AGR2 antibody can be used for detection of AGR2 by Western blot at 1 - 2 mug/mL.

Western Blot (WB) of anti-AGR2 antibody

Western blot analysis of AGR2 in Hela cell lysate with AGR2 antibody at (A) 1 and (B) 2 μg/mL
Rabbit Anti-AGR2 Polyclonal Antibody – Cat# MBS153577

Immunohistochemistry (IHC) of anti-AGR2 antibody

Immunohistochemistry of AGR2 in human small intestine tissue with AGR2 antibody at 5 μg/ml.
Rabbit Anti-AGR2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS153577

Immunofluorescence (IF) of anti-AGR2 antibody

Immunofluorescence of AGR2 in human small intestine tissue with AGR2 antibody at 20 μg/ml.
Rabbit Anti-AGR2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS153577

Other Notes

Small volumes of anti-AGR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AGR2 purchase

MBS153577 is an antibody targeting AGR2. Also known as AGR2 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AGR2. It may not necessarily be applicable to this product.

NCBI GI #
5453541
NCBI GeneID
10551
NCBI Accession #
NP_006399
UniProt Primary Accession #
O95994
UniProt Related Accession #
O95994
GenBank Nucleotide #
NM_006408.3
NCBI Official Full Name
anterior gradient protein 2 homolog
NCBI Official Synonym Full Names
anterior gradient 2
NCBI Official Symbol
AGR2
NCBI Official Synonym Symbols
AG2; GOB-4; HAG-2; XAG-2; PDIA17; HEL-S-116
UniProt Protein Name
Anterior gradient protein 2 homolog
UniProt Synonym Protein Names
HPC8; Secreted cement gland protein XAG-2 homolog
Protein Family
Anterior gradient protein
UniProt Gene Name
AGR2
UniProt Synonym Gene Names
AG2; AG-2; hAG-2
UniProt Entry Name
AGR2_HUMAN
NCBI Protein Information
anterior gradient protein 2 homolog; AG-2; HPC8; anterior gradient homolog 2; secreted cement gland homolog; epididymis secretory protein Li 116; secreted cement gland protein XAG-2 homolog; protein disulfide isomerase family A, member 17

UniProt Comments for AGR2

AGR2: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked. Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines. Belongs to the AGR family.

Protein type: Secreted; Secreted, signal peptide; Oncoprotein

Chromosomal Location of Human Ortholog: 7p21.3

Cellular Component: mitochondrion; endoplasmic reticulum; extracellular region

Molecular Function: protein binding
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Research Articles on AGR2

1. Data demonstrates that AGR2 protein has a more dominant action on proteome remodelling rather than transcriptome effects and highlight a dominant effect on p53 pathway attenuation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AGR2 antibody

 Reference Product  PubMed Publications
 AGR3 antibody  >9 publications with AGR2 and AGR3
 TFF1 antibody  >7 publications with AGR2 and TFF1
 MUC2 antibody  >7 publications with AGR2 and MUC2
 FOXA1 antibody  >3 publications with AGR2 and FOXA1
 RUVBL2 antibody  >2 publications with AGR2 and RUVBL2
 TFF3 antibody  >1 publications with AGR2 and TFF3

Diseases associated with anti-AGR2 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >56 publications with AGR2 and Carcinoma
 Adenocarcinoma Antibodies  >39 publications with AGR2 and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >35 publications with AGR2 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >28 publications with AGR2 and Breast Neoplasms
 Prostatic Neoplasms Antibodies  >16 publications with AGR2 and Prostatic Neoplasms
 Pancreatic Neoplasms Antibodies  >12 publications with AGR2 and Pancreatic Neoplasms
 Lung Diseases Antibodies  >12 publications with AGR2 and Lung Diseases
 Neoplasm Invasiveness Antibodies  >9 publications with AGR2 and Neoplasm Invasiveness
 Lung Neoplasms Antibodies  >9 publications with AGR2 and Lung Neoplasms
 Inflammation Antibodies  >8 publications with AGR2 and Inflammation

Organs/Tissues associated with anti-AGR2 antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >30 publications with AGR2 and Prostate
 Intestine Antibodies  >19 publications with AGR2 and Intestine
 Lung Antibodies  >18 publications with AGR2 and Lung
 Larynx Antibodies  >7 publications with AGR2 and Larynx
 Pancreas Antibodies  >7 publications with AGR2 and Pancreas
 Stomach Antibodies  >7 publications with AGR2 and Stomach
 Liver Antibodies  >6 publications with AGR2 and Liver
 Bladder Antibodies  >5 publications with AGR2 and Bladder
 Mammary Gland Antibodies  >3 publications with AGR2 and Mammary Gland
 Heart Antibodies  >3 publications with AGR2 and Heart
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