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DNAJC13 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS153599

DNAJC13, also known as receptor-mediated endocytosis 8 (RME8), is the human homolog to a DnaJ domain-containing protein originally identified in a screen for endocytic defects in C. elegans (1). It is thought to be a co-chaperone of Hsc70 which regulates… More details

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Product Overview

Online Datasheet in PDF
Product Name
DNAJC13, Polyclonal Antibody
Full Product Name
DNAJC13 Antibody
Product Gene Name
anti-DNAJC13 antibody
Product Synonym Names
DNAJ homolog subfamily C member 13; receptor-mediated endocytosis 8; RME8; DnaJ (Hsp40) homolog, subfamily C, member 13
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid; DNAJC13 antibody is supplied in PBS containing 0.02% sodium azide.
Purity/Purification
DNAJC13 antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
DNAJC13 antibody is human and mouse reactive. At least two siforms of DNAJC13 are known to exist; this antibody will detect both isoforms. DNAJC13 antibody is predicted to not cross-react with other DNAJC family members.
Preparation and Storage
DNAJC13 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
Antibody/Peptide Pairs
DNAJC13 peptide (MBS153800) is used for blocking the activity of DNAJC13 antibody (MBS153599)
Molecular Weight
Predicted: 249 kDa

Observed: 249 kDa
OMIM
614334
3D Structure
ModBase 3D Structure for O75165
Immunogen
DNAJC13 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human DNAJC13.
The immunogen is located within amino acids 1940 - 1990 of DNAJC13.
Positive Control
1) Cat. No. MBS151755 - Human Heart Tissue Lysate
2) Cat. No. MBS154198 - Human Heart Tissue Slide
Applications Tested/Suitable for anti-DNAJC13 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)
Application Notes for anti-DNAJC13 antibody
DNAJC13 antibody can be used for detection of DNAJC13 by Western blot at 1 - 2 ug/mL. Antibody can also be used for immunohistochemistry starting at 5 ug/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Optimal dilutions for each application to be determined by the researcher.

Western Blot (WB) of anti-DNAJC13 antibody

DNAJC13 Antibody.
Rabbit Anti-DNAJC13 Polyclonal Antibody – Cat# MBS153599

Immunohistochemistry (IHC) of anti-DNAJC13 antibody

Immunohistochemistry of DNAJC13 in human heart tissue with DNAJC13 antibody at 5 μg/mL.
Rabbit Anti-DNAJC13 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS153599

Other Notes

Small volumes of anti-DNAJC13 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DNAJC13 purchase

MBS153599 is an antibody targeting DNAJC13. Also known as DNAJC13 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DNAJC13. It may not necessarily be applicable to this product.

NCBI GI #
112421122
NCBI GeneID
23317
NCBI Accession #
NP_056083
UniProt Primary Accession #
O75165
UniProt Secondary Accession #
Q3L0T1; Q6PI82; Q6UJ77; Q6ZSW1; Q6ZUT5; Q86XG3; Q96DC1; Q9BWK9
UniProt Related Accession #
O75165
GenBank Nucleotide #
NM_015268.3
NCBI Official Full Name
dnaJ homolog subfamily C member 13
NCBI Official Synonym Full Names
DnaJ (Hsp40) homolog, subfamily C, member 13
NCBI Official Symbol
DNAJC13
NCBI Official Synonym Symbols
RME8
UniProt Protein Name
DnaJ homolog subfamily C member 13
UniProt Synonym Protein Names
Required for receptor-mediated endocytosis 8; RME-8
Protein Family
DnaJ homolog subfamily
UniProt Gene Name
DNAJC13
UniProt Synonym Gene Names
KIAA0678; RME8; RME-8
UniProt Entry Name
DJC13_HUMAN
NCBI Protein Information
dnaJ homolog subfamily C member 13; RME-8; DnaJ domain-containing protein RME-8; required for receptor-mediated endocytosis 8

UniProt Comments for DNAJC13

DNAJC13: Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR (PubMed:18256511, PubMed:18307993). Involved in the regulation of endosomal membrane tubulation and regulates th dynamics of SNX1 on the endosomal membrane; via association with FAM21 may link the WASH complex to the retromer SNX-BAR subcomplex (PubMed:24643499). {ECO:0000269|PubMed:18256511, ECO:0000269|PubMed:18307993, ECO:0000269|PubMed:24643499}. Interacts with FAM21C; mediates the association with the WASH complex (PubMed:24643499). {ECO:0000269|PubMed:24643499}

Protein type: Chaperone

Chromosomal Location of Human Ortholog: 3q22.1

Cellular Component: membrane; early endosome membrane; lysosomal membrane; endosome membrane

Molecular Function: protein binding

Biological Process: osteoblast differentiation; protein transport; endosome organization and biogenesis

Disease: Parkinson Disease 21
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Research Articles on DNAJC13

1. Data propose that the interaction between RME-8 and the WASH complex provides a means to coordinate the activity of the WASH complex with the membrane-tubulating function of the sorting.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-DNAJC13 antibody

 Disease Name  Pubmed Publications
 Central Nervous System Diseases Antibodies  >4 publications with DNAJC13 and Central Nervous System Diseases
 Mental Disorders Antibodies  >3 publications with DNAJC13 and Mental Disorders
 Breast Neoplasms Antibodies  >1 publications with DNAJC13 and Breast Neoplasms

Organs/Tissues associated with anti-DNAJC13 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with DNAJC13 and Brain
 Liver Antibodies  >1 publications with DNAJC13 and Liver
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