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C2CD3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS153678

C2CD3, a putative calcium-dependent lipid-binding protein, is an essential regulator of intracellular transduction of the Hedgehog signal (1). It is localized at the basal body of cilia, mediates calcium-dependent vesicular transport and/or recruitment of… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
C2CD3, Polyclonal Antibody
Full Product Name
C2CD3 Antibody
Product Gene Name
Product Synonym Names
C2 calcium-dependent domain containing 3; C2 domain-containing protein 3; C2 calcium-dependent domain containing 3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
C2CD3 antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
C2CD3 antibody is human, mouse and rat reactive.
Preparation and Storage
C2CD3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
Antibody/Peptide Pairs
C2CD3 peptide (MBS154144) is used for blocking the activity of C2CD3 antibody (MBS153678)
Molecular Weight
Predicted: 216; 259 kDa

Observed: 255 kDa
OMIM
615944
3D Structure
ModBase 3D Structure for Q4AC94
Conjugate
Unconjugated
Immunogen
C2CD3 antibody was raised against an 18 amino acid peptide near the center of human C2CD3.
Buffer
C2CD3 antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-C2CD3 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-C2CD3 antibody
C2CD3 antibody can be used for detection of C2CD3 by Western blot at 1 - 2 mug/ml.

Western Blot (WB) of anti-C2CD3 antibody

Western blot analysis of C2CD3 in EL4 cell lysate with C2CD3 antibody at (A) 1 and (B) 2 μg/ml.
Rabbit Anti-C2CD3 Polyclonal Antibody – Cat# MBS153678

Other Notes

Small volumes of anti-C2CD3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for C2CD3 purchase

MBS153678 is an antibody targeting C2CD3. Also known as C2CD3 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for C2CD3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
C2 domain-containing protein 3 isoform 2
NCBI Official Synonym Full Names
C2 calcium-dependent domain containing 3
NCBI Official Symbol
C2CD3
NCBI Official Synonym Symbols
OFD14
UniProt Protein Name
C2 domain-containing protein 3
UniProt Gene Name
C2CD3
UniProt Entry Name
C2CD3_HUMAN
NCBI Protein Information
C2 domain-containing protein 3

NCBI Summary for C2CD3

This gene encodes a protein that functions as a regulator of centriole elongation. Studies of the orthologous mouse protein show that it promotes centriolar distal appendage assembly and is also required for the recruitment of other ciliogenic proteins, including intraflagellar transport proteins. Mutations in this gene cause orofaciodigital syndrome XIV (OFD14), a ciliopathy resulting in malformations of the oral cavity, face and digits. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]
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UniProt Comments for C2CD3

C2CD3: 5 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: centriole; centrosome; cytosol

Molecular Function: protein binding

Biological Process: neural tube development; sensory cilium biogenesis; in utero embryonic development; organelle organization and biogenesis; neural plate pattern formation; regulation of proteolysis; protein processing; embryonic digit morphogenesis; heart looping; brain development; regulation of smoothened signaling pathway

Disease: Orofaciodigital Syndrome Xiv
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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