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QSOX1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS153698

The QSOX1 gene, also known as Quiescin Q6, is a fusion of two ancient genes: thioredoxin and ERV1. Its expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
QSOX1, Polyclonal Antibody
Full Product Name
QSOX1 Antibody
Product Gene Name
anti-QSOX1 antibody
Product Synonym Names
Quiescin Q6 sulfhydryl oxidase 1; Sulfhydryl oxidase 1; Q6; QSCN6; quiescin Q6 sulfhydryl oxidase 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
QSOX1 antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
QSOX1 antibody is human and mouse reactive. QSOX1 antibody is predicted to not cross-react with QSOX2.
Preparation and Storage
QSOX1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
Antibody/Peptide Pairs
QSOX1 peptide (MBS153838) is used for blocking the activity of QSOX1 antibody (MBS153698)
Molecular Weight
Predicted: 65; 82 kDa

Observed: 66 kDa
OMIM
603120
3D Structure
ModBase 3D Structure for O00391
Conjugate
Unconjugated
Immunogen
QSOX1 antibody was raised against a 17 amino acid peptide near the center of human QSOX1.
Buffer
QSOX1 antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-QSOX1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-QSOX1 antibody
QSOX1 antibody can be used for detection of QSOX1 by Western blot at 1 - 2 mug/ml.

Western Blot (WB) of anti-QSOX1 antibody

Western blot analysis of QSOX1 in EL4 cell lysate with QSOX1 antibody at (A) 1 and (B) 2 μg/ml.
Rabbit Anti-QSOX1 Polyclonal Antibody – Cat# MBS153698

Immunohistochemistry (IHC) of anti-QSOX1 antibody

Immunohistochemistry of QSOX1 in human spleen tissue with QSOX1 antibody at 5 μg/mL.
Rabbit Anti-QSOX1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS153698

Immunofluorescence (IF) of anti-QSOX1 antibody

Immunofluorescence of QSOX1 in human spleen tissue with QSOX1 antibody at 20 μg/ml.
Rabbit Anti-QSOX1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS153698

Immunofluorescence (IF) of anti-QSOX1 antibody

Immunofluorescence of QSOX1 in human spleen tissue with QSOX1 antibody at 20 μg/ml.
Rabbit Anti-QSOX1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS153698

Other Notes

Small volumes of anti-QSOX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for QSOX1 purchase

MBS153698 is an antibody targeting QSOX1. Also known as QSOX1 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for QSOX1. It may not necessarily be applicable to this product.

NCBI GI #
13325075
NCBI GeneID
5768
NCBI Accession #
NP_002817
UniProt Primary Accession #
O00391
UniProt Secondary Accession #
Q59G29; Q5T2X0; Q8TDL6; Q8WVP4
UniProt Related Accession #
O00391
GenBank Nucleotide #
NM_002826.4
NCBI Official Full Name
sulfhydryl oxidase 1 isoform a
NCBI Official Synonym Full Names
quiescin Q6 sulfhydryl oxidase 1
NCBI Official Symbol
QSOX1
NCBI Official Synonym Symbols
Q6; QSCN6
UniProt Protein Name
Sulfhydryl oxidase 1
UniProt Synonym Protein Names
Quiescin Q6
Protein Family
Sulfhydryl oxidase
UniProt Gene Name
QSOX1
UniProt Synonym Gene Names
QSCN6; hQSOX
UniProt Entry Name
QSOX1_HUMAN
NCBI Protein Information
sulfhydryl oxidase 1; hQSOX

NCBI Summary for QSOX1

This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for QSOX1

quiescin Q6: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor- suppressing capabilities being involved in growth regulation. Belongs to the quiescin-sulfhydryl oxidase (QSOX) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Membrane protein, integral; EC 1.8.3.2

Chromosomal Location of Human Ortholog: 1q24

Cellular Component: Golgi apparatus; extracellular space; intercellular bridge; intracellular membrane-bound organelle; integral to Golgi membrane

Molecular Function: protein disulfide isomerase activity; flavin-linked sulfhydryl oxidase activity

Biological Process: protein folding; cell redox homeostasis
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Research Articles on QSOX1

1. Examination of the unusual kinetics of QSOX1 toward cysteine and glutathione at low micromolar concentrations suggests that circulating QSOX1 is unlikely to significantly contribute to the oxidation of these monothiols in plasma

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-QSOX1 antibody

 Reference Product  PubMed Publications
 GFER antibody  >2 publications with QSOX1 and GFER

Diseases associated with anti-QSOX1 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >5 publications with QSOX1 and Adenocarcinoma
 Heart Diseases Antibodies  >2 publications with QSOX1 and Heart Diseases
 Cardiovascular Diseases Antibodies  >2 publications with QSOX1 and Cardiovascular Diseases
 Neoplasm Metastasis Antibodies  >1 publications with QSOX1 and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >1 publications with QSOX1 and Disease Models, Animal
 Lung Neoplasms Antibodies  >1 publications with QSOX1 and Lung Neoplasms
 Nervous System Diseases Antibodies  >1 publications with QSOX1 and Nervous System Diseases
 Breast Neoplasms Antibodies  >1 publications with QSOX1 and Breast Neoplasms
 Atherosclerosis Antibodies  >1 publications with QSOX1 and Atherosclerosis
 Inflammation Antibodies  >1 publications with QSOX1 and Inflammation

Organs/Tissues associated with anti-QSOX1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with QSOX1 and Blood
 Liver Antibodies  >5 publications with QSOX1 and Liver
 Prostate Antibodies  >4 publications with QSOX1 and Prostate
 Heart Antibodies  >4 publications with QSOX1 and Heart
 Lung Antibodies  >4 publications with QSOX1 and Lung
 Pancreas Antibodies  >2 publications with QSOX1 and Pancreas
 Vascular Antibodies  >2 publications with QSOX1 and Vascular
 Muscle Antibodies  >2 publications with QSOX1 and Muscle
 Bone Antibodies  >2 publications with QSOX1 and Bone
 Lymph Node Antibodies  >1 publications with QSOX1 and Lymph Node
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