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NOSTRIN Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS153699

NOSTRIN. also known as endothelial nitric oxide synthase traffic inducer, is a member of the Pombe Cdc15 homology (PCH) family of proteins which may function as the modulator of the subcellular localisation and activity of endothelial nitric oxide synthase… More details

$530 / 0.1 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
NOSTRIN, Polyclonal Antibody
Full Product Name
NOSTRIN Antibody
Product Gene Name
Product Synonym Names
Nitric oxide synthase traffic inducer; eNOS-trafficking inducer; Nitric oxide synthase trafficker; BM247 homolog; DaIP2; nitric oxide synthase trafficking
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
NOSTRIN antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
NOSTRIN antibody is human, mouse and rat reactive. At least four isoforms are known to exist; this antibody will detect all four isoforms.
Preparation and Storage
NOSTRIN antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
Antibody/Peptide Pairs
NOSTRIN peptide (MBS153833) is used for blocking the activity of NOSTRIN antibody (MBS153699)
Molecular Weight
Predicted: 47; 53; 56; 62 kDa

Observed: 68 kDa
OMIM
607496
3D Structure
ModBase 3D Structure for Q8IVI9
Conjugate
Unconjugated
Immunogen
NOSTRIN antibody was raised against a 17 amino acid peptide near the carboxy terminus of human NOSTRIN.
Buffer
NOSTRIN antibody is supplied in PBS containing 0.02% sodium azide.
Applications Tested/Suitable for anti-NOSTRIN antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-NOSTRIN antibody
NOSTRIN antibody can be used for detection of NOSTRIN by Western blot at 1 - 2 mug/ml. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Western Blot (WB) of anti-NOSTRIN antibody

Western blot analysis of NOSTRIN in SW480 cell lysate with NOSTRIN antibody at (A) 1 and (B) 2 μg/ml.
Rabbit Anti-NOSTRIN Polyclonal Antibody – Cat# MBS153699

Immunohistochemistry (IHC) of anti-NOSTRIN antibody

Immunohistochemistry of NOSTRIN in mouse kidney tissue with NOSTRIN antibody at 5 μg/ml.
Rabbit Anti-NOSTRIN Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS153699

Immunofluorescence (IF) of anti-NOSTRIN antibody

Immunofluorescence of NOSTRIN in mouse kidney tissue with NOSTRIN antibody at 20 μg/ml.
Rabbit Anti-NOSTRIN Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS153699

Other Notes

Small volumes of anti-NOSTRIN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NOSTRIN purchase

MBS153699 is an antibody targeting NOSTRIN. Also known as NOSTRIN Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NOSTRIN. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
nostrin isoform 1
NCBI Official Synonym Full Names
nitric oxide synthase trafficking
NCBI Official Symbol
NOSTRIN
NCBI Official Synonym Symbols
DaIP2
UniProt Protein Name
Nostrin
UniProt Synonym Protein Names
BM247 homolog; Nitric oxide synthase traffic inducer; Nitric oxide synthase trafficker; eNOS-trafficking inducer
Protein Family
UniProt Gene Name
NOSTRIN
UniProt Entry Name
NOSTN_HUMAN
NCBI Protein Information
nostrin; BM247 homolog; ENOS traffic inducer; eNOS-trafficking inducer; nitric oxide synthase trafficker; nitric oxide synthase traffic inducer; endothelial nitric oxide synthase traffic inducer; ortholog of mouse disabled 2 interacting proein 2

NCBI Summary for NOSTRIN

Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004]
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UniProt Comments for NOSTRIN

NOSTRIN: Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: cytoskeleton; plasma membrane; nucleus

Molecular Function: protein binding; DNA binding

Biological Process: endocytosis; regulation of nitric-oxide synthase activity; negative regulation of transcription, DNA-dependent; signal transduction; nitric oxide metabolic process
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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