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TNFAIP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS154370

TNFAIP1 is a BTB/POZ domain-containing protein that belongs to the KCTD10/BACURD family which mediates POZ-POZ interactions and chromatin modeling (1,2). The expression of TNFAIP1 is developmentally regulated in a tissue-specific manner and can be induced by… More details

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Product Overview

Online Datasheet in PDF
Product Name
TNFAIP1, Polyclonal Antibody
Full Product Name
TNFAIP1 Antibody
Product Gene Name
anti-TNFAIP1 antibody
Product Synonym Names
Tumor necrosis factor, alpha-induced protein 1, BTB/POZ domain-containing protein TNFAIP1,BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2, BACURD2, EDP1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
Affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
TNFAIP1 antibody is human, mouse and rat reactive. TNFAIP1 antibody is predicted to not cross-react with other TNFAIP proteins.
Preparation and Storage
Store at 4 degree C for three months and -20 degree C, stable for up to one year.
Antibody/Peptide Pairs
TNFAIP1 peptide (MBS154430) is used for blocking the activity of TNFAIP1 antibody (MBS154370)
Molecular Weight
Predicted: 35 kDa
Observed: 35 kDa
OMIM
191161
3D Structure
ModBase 3D Structure for Q13829
Immunogen
TNFAIP1 antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human TNFAIP1.
Buffer
Supplied in PBS containing 0.02% sodium azide.
Positive Control 1
Mouse Brain Tissue Lysate
Conjugate
Unconjugated

Product Categories/Family for anti-TNFAIP1 antibody

Apoptosis; Cancer; Innate Immunity
Applications Tested/Suitable for anti-TNFAIP1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-TNFAIP1 antibody
TNFAIP1 antibody can be used for the detection of TNFAIP1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry at 10 mug/ml.

Western Blot (WB) of anti-TNFAIP1 antibody

Western blot analysis of TNFAIP1 in mouse brain tissue lysate with TNFAIP1 antibody at 1 μg/ml.
Rabbit Anti-TNFAIP1 Polyclonal Antibody – Cat# MBS154370

Immunohistochemistry (IHC) of anti-TNFAIP1 antibody

Immunohistochemistry of TNFAIP1 in mouse brain tissue with TNFAIP1 antibody at 10 μg/ml.
Rabbit Anti-TNFAIP1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS154370

Immunofluorescence (IF) of anti-TNFAIP1 antibody

Immunofluorescence of TNFAIP1 in mouse brain tissue with TNFAIP1 antibody at 20 μg/ml.

Red: TNFAIP1 Antibody (8345)
Blue: DAPI staining
Rabbit Anti-TNFAIP1 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS154370

Product References and Citations for anti-TNFAIP1 antibody

Liu M, Sun Z, Zhou A, et al. Functional characterization of the promoter region of human TNFAIP1 gene. Mol. Biol. Rep. 2010; 37:1699-705. Hu X, Yan F, Wang F, et al. TNFAIP1 interacts with KCTD10 to promote the degradation of KCTD10 proteins and inhibit the transcriptional activities of NF-kappaB and AP-1. Mol. Biol. Rep. 2012; 39:9911-9. Zhang CL, Wang C, Yan WJ, et al. Knockdown of TNFAIP1 inhibits growth and induces apoptosis in osteosarcoma cells through inhibition of the nuclear factor-?B pathway. Oncol. Rep. 2014; 32:1149-55. Kim DM, Chung KS, Choi SJ, et al. RhoB induces apoptosis via direct interaction with TNFAIP1 in HeLa cells. Int. J. Cancer 2009; 125:2520-7.

Other Notes

Small volumes of anti-TNFAIP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFAIP1 purchase

MBS154370 is an antibody targeting TNFAIP1. Also known as TNFAIP1 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFAIP1. It may not necessarily be applicable to this product.

NCBI GI #
10863937
NCBI GeneID
7126
NCBI Accession #
NP_066960
UniProt Primary Accession #
Q13829
UniProt Secondary Accession #
Q5TZQ1; B7Z6M4
UniProt Related Accession #
Q13829
GenBank Nucleotide #
NM_021137.4
NCBI Official Full Name
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
NCBI Official Synonym Full Names
TNF alpha induced protein 1
NCBI Official Symbol
TNFAIP1
NCBI Official Synonym Symbols
B12; B61; EDP1; BTBD34; hBACURD2
UniProt Protein Name
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
UniProt Synonym Protein Names
BTB/POZ domain-containing protein TNFAIP1; Protein B12; Tumor necrosis factor, alpha-induced protein 1, endothelial
Protein Family
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein
UniProt Gene Name
TNFAIP1
UniProt Synonym Gene Names
BACURD2; EDP1; hBACURD2
UniProt Entry Name
BACD2_HUMAN
NCBI Protein Information
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

NCBI Summary for TNFAIP1

This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008]
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UniProt Comments for TNFAIP1

TNFAIP1: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. Belongs to the BACURD family.

Protein type: Ubiquitin conjugating system; DNA replication

Chromosomal Location of Human Ortholog: 17q22-q23

Cellular Component: cytoplasm; endosome; nucleolus

Molecular Function: GTP-Rho binding; protein binding; protein domain specific binding; ubiquitin-protein ligase activity

Biological Process: apoptosis; cell migration; DNA replication; embryonic development; immune response; negative regulation of Rho protein signal transduction; positive regulation of DNA replication; proteasomal ubiquitin-dependent protein catabolic process; protein homooligomerization; protein ubiquitination; stress fiber formation
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Research Articles on TNFAIP1

1. MiR-181a played a critical role in regulating pancreatic cancer growth and migration, likely interacting with TNFAIP1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TNFAIP1 antibody

 Reference Product  PubMed Publications
 RHOB antibody  >2 publications with TNFAIP1 and RHOB
 CUL3 antibody  >2 publications with TNFAIP1 and CUL3
 KCTD13 antibody  >2 publications with TNFAIP1 and KCTD13

Diseases associated with anti-TNFAIP1 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >22 publications with TNFAIP1 and Necrosis
 Inflammation Antibodies  >4 publications with TNFAIP1 and Inflammation
 Neoplasm Metastasis Antibodies  >3 publications with TNFAIP1 and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >2 publications with TNFAIP1 and Adenocarcinoma
 Disease Models, Animal Antibodies  >2 publications with TNFAIP1 and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >1 publications with TNFAIP1 and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >1 publications with TNFAIP1 and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >1 publications with TNFAIP1 and Liver Neoplasms
 Kidney Diseases Antibodies  >1 publications with TNFAIP1 and Kidney Diseases
 Fatty Liver Antibodies  >1 publications with TNFAIP1 and Fatty Liver

Organs/Tissues associated with anti-TNFAIP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with TNFAIP1 and Brain
 Blood Antibodies  >4 publications with TNFAIP1 and Blood
 Liver Antibodies  >4 publications with TNFAIP1 and Liver
 Bone Antibodies  >2 publications with TNFAIP1 and Bone
 Embryonic Tissue Antibodies  >2 publications with TNFAIP1 and Embryonic Tissue
 Lung Antibodies  >2 publications with TNFAIP1 and Lung
 Kidney Antibodies  >1 publications with TNFAIP1 and Kidney
 Stomach Antibodies  >1 publications with TNFAIP1 and Stomach
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