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INPP4B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS154378

Inositol polyphosphate 4-phosphatase type II (INPP4B) is one of the enzymes involved in phosphatidylinositol signaling pathways. It removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate (1). INPP4B can function as a… More details

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Product Overview

Online Datasheet in PDF
Product Name
INPP4B, Polyclonal Antibody
Full Product Name
INPP4B Antibody
Product Gene Name
anti-INPP4B antibody
Product Synonym Names
Inositol polyphosphate-4-phosphatase type II 105kDa
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
Affinity chromatography purified via peptide column.
Concentration
1 mg/mL (lot specific)
Specificity
INPP4B antibody is human, mouse and rat reactive. At least two isoforms of INPP4B are known to exist; this antibody only detects the longer isoform. INPP4B antibody is predicted to not cross-react with INPP4A.
Preparation and Storage
Store at 4 degree C for three months and -20 degree C, stable for up to one year.
Antibody/Peptide Pairs
INPP4B peptide (MBS154405) is used for blocking the activity of INPP4B antibody (MBS154378)
Molecular Weight
Predicted: 102 kDa
Observed: 100 kDa
OMIM
607494
3D Structure
ModBase 3D Structure for Q9BS68
Immunogen
INPP4B antibody was raised against a 17 amino acid peptide near the amino terminus of human INPP4B.
Buffer
Supplied in PBS containing 0.02% sodium azide.
Positive Control 1
3T3 Cell Lysate
Conjugate
Unconjugated

Product Categories/Family for anti-INPP4B antibody

Cancer; Cell Cycle
Applications Tested/Suitable for anti-INPP4B antibody
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)
Application Notes for anti-INPP4B antibody
INPP4B antibody can be used for detection of INPP4B by Western blot at 1 - 2 mug/ml. Antibody can also be used for immunocytochemistry starting at 2.5 mug/mL.

Western Blot (WB) of anti-INPP4B antibody

Western blot analysis of INPP4B in 3T3 cell lysate with INPP4B antibody at 1 μg/ml.
Rabbit Anti-INPP4B Polyclonal Antibody – Cat# MBS154378

Immunocytochemistry (IHC) of anti-INPP4B antibody

Immunocytochemistry of INPP4B in 3T3 cells with INPP4B antibody at 2.5 μg/ml.
Rabbit Anti-INPP4B Polyclonal Antibody, Immunocytochemistry (IHC) – Cat# MBS154378

Product References and Citations for anti-INPP4B antibody

Norris FA, Auethavekiat V, and Majerus PW. The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphase. J. Biol. Chem. 1995; 270:16128-33. Gewinner C, Wang ZC, Richardson A, et al. Evidence that inositol polyphosphate 4-phosphase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell 2009; 16:115-25. Gasser JA, Inuzuka H, Lau AW, et al. SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer. Mol. Cell 2014; 56:595-607.

Other Notes

Small volumes of anti-INPP4B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for INPP4B purchase

MBS154378 is an antibody targeting INPP4B. Also known as INPP4B Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for INPP4B. It may not necessarily be applicable to this product.

NCBI GI #
156104895
NCBI GeneID
8821
NCBI Accession #
NP_003857
UniProt Primary Accession #
Q9BS68
UniProt Secondary Accession #
Q2TAI2; Q5XLE7; Q6IN59; Q6PJB4
UniProt Related Accession #
O15327
GenBank Nucleotide #
NM_003866.2
NCBI Official Full Name
type II inositol 3,4-bisphosphate 4-phosphatase
NCBI Official Synonym Full Names
inositol polyphosphate-4-phosphatase type II B
NCBI Official Symbol
INPP4B
UniProt Protein Name
Type II inositol 3,4-bisphosphate 4-phosphatase
UniProt Synonym Protein Names
Inositol polyphosphate 4-phosphatase type II
Protein Family
Type II inositol 3,4-bisphosphate 4-phosphatase
UniProt Gene Name
INPP4B
UniProt Entry Name
INP4B_HUMAN
NCBI Protein Information
type II inositol 3,4-bisphosphate 4-phosphatase

NCBI Summary for INPP4B

INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]
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UniProt Comments for INPP4B

INPP4B: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate. Widely expressed with highest levels occurring in the skeletal muscle and heart. Strongly inhibited by inositol hexakisphosphate. Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

Protein type: Carbohydrate Metabolism - inositol phosphate; Phosphatase, lipid; EC 3.1.3.66; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q31.21

Cellular Component: cytoplasm; cytosol

Molecular Function: inositol-1,3,4-trisphosphate 4-phosphatase activity; phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity; protein binding

Biological Process: dephosphorylation; inositol phosphate metabolic process; phosphatidylinositol biosynthetic process; signal transduction
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Research Articles on INPP4B

1. Studies in human tissues suggest that reductions in INPP4B and PTEN co-occur in human thyroid and endometrial cancers. INPP4B may therefore be an important regulator of cancer progression, especially in the context of PTEN insufficiency.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-INPP4B antibody

 Products by Pathway  Pathway Diagram
 3-phosphoinositide Degradation Pathway antibodies  3-phosphoinositide Degradation Pathway Diagram
 3-phosphoinositide Degradation Pathway antibodies  3-phosphoinositide Degradation Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => Myo-inositol Pathway antibodies  Inositol Phosphate Metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => Myo-inositol Pathway Diagram
 Inositol Phosphate Metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => Myo-inositol Pathway antibodies  Inositol Phosphate Metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => Myo-inositol Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram

Organs/Tissues associated with anti-INPP4B antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >12 publications with INPP4B and Prostate
 Lung Antibodies  >5 publications with INPP4B and Lung
 Bone Antibodies  >4 publications with INPP4B and Bone
 Nerve Antibodies  >4 publications with INPP4B and Nerve
 Brain Antibodies  >3 publications with INPP4B and Brain
 Liver Antibodies  >2 publications with INPP4B and Liver
 Bone Marrow Antibodies  >2 publications with INPP4B and Bone Marrow
 Kidney Antibodies  >2 publications with INPP4B and Kidney
 Connective Tissue Antibodies  >1 publications with INPP4B and Connective Tissue
 Muscle Antibodies  >1 publications with INPP4B and Muscle
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