BCLAF1 Antibody – Rabbit Polyclonal

This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

BCLAF1: a ubiquitous death-promoting transcriptional repressor. Interacts with Bcl-2 related proteins, lamin A, emerin, the adenovirus E1B 19 kDa protein and DNA. An emerin mutant S54F, which binds normally to barrier-to-autointegration factor (BAF), lamin A and GCL, selectively disrupts its binding to BCLAF1. BCLAF1 is found in dot-like structures throughout the nuclear interior in HeLa cells. Proapoptotic stimuli induce its redistribution to a distinct zone near the nuclear envelope. Four alternatively spliced human isoforms have been described.

Protein type: Transcription factor; RNA-binding

Chromosomal Location of Human Ortholog: 6q23.3

Cellular Component: cytoplasm; nuclear speck; nucleolus; nucleoplasm; nucleus

Molecular Function: DNA binding; protein binding

Biological Process: apoptosis; negative regulation of transcription, DNA-dependent; positive regulation of apoptosis; regulation of transcription in response to stress; transcription, DNA-dependent