Rabbit Anti-PIEZO2 Polyclonal Antibody – Cat# MBS154458

Western blot analysis of PIEZO2 in SK-N-SH cell lysate with PIEZO2 antibody at (A) 1 and (B) 2 μg/mL.

PIEZO2 Antibody – Rabbit Polyclonal

Name: PIEZO2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS154458
Price: 530 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS154458

PIEZO2 is a mechanically-activated ion channel that links mechanical forces to biological signals. The encoded protein contains thirty transmembrane domains and likely functions as part of mechanically-activated (MA) cation channels. These channels serve to… More details

$530 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PIEZO2, Polyclonal Antibody

Full Product Name

PIEZO2 Antibody

Product Gene Name

anti-PIEZO2 antibody

Product Synonym Names

PIEZO2 Antibody; C18orf30; C18orf58; DA3; DA5; DAIPT; FAM38B; FAM38B2; HsT748; HsT771; MWKS; piezo type mechanosensitive ion channel component 2

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Liquid

Purity/Purification

Affinity chromatography purified via peptide column.

Concentration

1 mg/mL (lot specific)

Specificity

PIEZO2 Antibody is predicted to not cross-react with PIEZO1.

Preparation and Storage

Store at 4 degree C for three months and -20 degree C, stable for up to one year.
As with all antibodies care should be taken to avoid repeated freeze thaw cycles
Antibodies should not be exposed to prolonged high temperatures.

Antibody/Peptide Pairs

PIEZO2 peptide (MBS154500) is used for blocking the activity of PIEZO2 antibody (MBS154458)

Molecular Weight

Predicted: 233, 305 kDa
Observed: 235 kDa

OMIM

JN790819 mRNA

3D Structure

ModBase 3D Structure for Q92508

Conjugate

Unconjugated

Immunogen

PIEZO2 antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human PIEZO2.

Buffer

PIEZO2 Antibody is supplied in PBS containing 0.02% sodium azide.

Species

Human

Product Categories/Family for anti-PIEZO2 antibody

Cell Cycle; Cancer

Applications Tested/Suitable for anti-PIEZO2 antibody

ELISA (EIA), Western Blot (WB)

Application Notes for anti-PIEZO2 antibody

Western blot at 1 - 2 mug/mL.

Other Notes

Small volumes of anti-PIEZO2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PIEZO2 purchase

MBS154458 is an antibody targeting PIEZO2. Also known as PIEZO2 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PIEZO2. It may not necessarily be applicable to this product.

NCBI GI #

257900451

NCBI GeneID

63895

NCBI Accession #

NP_071351

UniProt Primary Accession #

Q92508

UniProt Secondary Accession #

Q6ZS91; Q8N787; Q8NAR6; Q9H5R4; B7Z812; M4GPJ9

UniProt Related Accession #

Q9H5I5

GenBank Nucleotide #

NM_022068.3

NCBI Official Full Name

piezo-type mechanosensitive ion channel component 2

NCBI Official Synonym Full Names

piezo type mechanosensitive ion channel component 2

NCBI Official Symbol

PIEZO2

NCBI Official Synonym Symbols

DA3; DA5; MWKS; DAIPT; FAM38B; HsT748; HsT771; FAM38B2; C18orf30; C18orf58

UniProt Protein Name

Piezo-type mechanosensitive ion channel component 2

UniProt Synonym Protein Names

Protein FAM38B

Protein Family

Piezo-type mechanosensitive ion channel component

UniProt Gene Name

PIEZO2

UniProt Synonym Gene Names

C18orf30; C18orf58; FAM38B

NCBI Protein Information

piezo-type mechanosensitive ion channel component 2

NCBI Summary for PIEZO2

The protein encoded by this gene contains more than thirty transmembrane domains and likely functions as part of mechanically-activated (MA) cation channels. These channels serve to connect mechanical forces to biological signals. The encoded protein quickly adapts MA currents in somatosensory neurons. Defects in this gene are a cause of type 5 distal arthrogryposis. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]

UniProt Comments for PIEZO2

FAM38B: Component of mechanosensitive channel required for rapidly adaptating mechanically activated (MA) currents in DRG neurons. Belongs to the PIEZO family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 18p11.22-p11.21

Cellular Component: plasma membrane

Molecular Function: cation channel activity; mechanically-gated ion channel activity

Biological Process: cation transport; detection of mechanical stimulus; detection of mechanical stimulus involved in sensory perception; regulation of membrane potential; response to mechanical stimulus

Research Articles on PIEZO2

1. we report a consanguineous family with three siblings who showed short stature, scoliosis, gross motor impairment, and a progressive form of contractures involving the distal joints that is distinct from that found in patients with domina Recessive mutations in PIEZO2 thus appear to cause a progressive phenotype that overlaps with, while being mostly distinct from that associated with dominant mutations in the same gene

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-PIEZO2 antibody

Disease Name	Pubmed Publications
Pain Antibodies	>2 publications with PIEZO2 and Pain
Neoplasms Antibodies	>1 publications with PIEZO2 and Neoplasms

Organs/Tissues associated with anti-PIEZO2 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1 publications with PIEZO2 and Blood