COVID 19 Nucleocapsid (Np) Coronavirus (COVID-19) Antibody – Rabbit Polyclonal

Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus. The disease is the cause of the 2019-20 coronavirus outbreak (1). SARS-CoV-2 is the seventh member of the enveloped, positive-stranded RNA viruses that are able to infect humans. The SARS-CoV-2 genome, like other coronaviruses, encodes for multiple structural and nonstructural proteins. The structural proteins include spike protein (S), envelope protein (E), membrane glycoprotein (M), nucleocapsid phosphoprotein (N), and the nonstructural proteins include open reading frame 1ab (ORF1ab), ORF3a, ORF6, ORF7a, ORF8, and ORF10 (2). Nucleocapsid (N) protein is the most abundant protein of coronavirus. It is also one of the major structural proteins and is involved in the transcription and replication of viral RNA, packaging of the encapsidated genome into virions (3), and interference with cell cycle processes of host cells (4). Moreover, in many coronaviruses, including SARS-CoV, the N protein has high immunogenic activity and is abundantly expressed during infection (5). It can be detected in various patient samples including nasopharyngeal aspirate, urine, and fecal. Both S and N proteins may be potential antigens for seroidentification of COVID-19, just as many identification methods have been developed for identifying SARS based on S and/or N proteins (6).

1) Zhu et al. N Engl J Med. 2020 Feb 20;382(8):727-733.
2) Kiyotani et al. J Hum Genet. 2020 Jul;65(7):569-575.
3) Chang et al. J Biomed Sci. 2006 Jan;13(1):59-72.
4) Cui et al. J Virol. 2015 Sep;89(17):9029-43.
5) Chen et al. Eur J Clin Microbiol Infect Dis. 2005 Aug;24(8):549-53.
6) Emerg Infect Dis. 2004 Sep;10(9):1558-62.

Small volumes of anti-COVID-19 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS154653 is an antibody targeting COVID-19. Also known as SARS-CoV-2 (COVID-19) Nucleocapsid Antibody. Reactive in Virus. Host: Rabbit.