Rabbit Anti-DKK2 Polyclonal Antibody – Cat# MBS1560195

DKK2 Antibody – Rabbit Polyclonal

Name: DKK2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1560195
Price: 370 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1560195

he Wnt genes are a group of well conserved, cysteine-rich secreted glycoproteins that are required for numerous develop-mental processes including embryogenesis, asymmetric cell division and central nervous system (CNS) patternins. Wnt association with the… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

DKK2, Polyclonal Antibody

Full Product Name

Anti DKK2 polyclonal antibody

Product Gene Name

anti-DKK2 antibody

Product Synonym Names

Dickkopf-related protein 2; Dickkopf-2; Dkk-2; hDkk-2; UNQ682/PRO1316

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human
Other species were not tested

Form/Format

Liquid. Supplied as solution form in PBS, pH7.4, containing 0.05% proclin300, 50% glycerol.

Purity/Purification

Antigen affinity purification

Concentration

0.5mg/ml (lot specific)

Preparation and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 degree C for frequentUse. Store at -20 to -80 degree C for twelve months from the date of receipt.

Molecular Weight

28,447 Da

Chromosome Location

Chromosome: 4; NC_000004.11 (107842959..107957453, complement). Location: 4q25

OMIM

605415

3D Structure

ModBase 3D Structure for Q9UBU2

Immunogen

Recombinant protein of human DKK2 (Lys34-Ile259)

Conjugation

Unconjugated

Product Categories/Family for anti-DKK2 antibody

Primary antibody

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-DKK2 antibody

Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-DKK2 antibody

WB: 1:2000-1:8000
IHC: 1:200-1:400

Product References and Citations for anti-DKK2 antibody

PMID: 15489334; PMID: 31355191; PMID: 31133849

Other Notes

Small volumes of anti-DKK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DKK2 purchase

MBS1560195 is an antibody targeting DKK2. Also known as Anti DKK2 polyclonal antibody. Reactive in Human
Other species were not tested. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DKK2. It may not necessarily be applicable to this product.

NCBI GI #

7657023

NCBI GeneID

27123

NCBI Accession #

NP_055236.1

UniProt Primary Accession #

Q9UBU2

UniProt Secondary Accession #

Q9UIU3; A0AVE9; B2R6S7

UniProt Related Accession #

Q9UBU2

GenBank Nucleotide #

NM_014421.2

NCBI Official Full Name

dickkopf-related protein 2

NCBI Official Synonym Full Names

dickkopf WNT signaling pathway inhibitor 2

NCBI Official Symbol

DKK2

NCBI Official Synonym Symbols

DKK-2

UniProt Protein Name

Dickkopf-related protein 2

Protein Family

Dickkopf-related protein

UniProt Gene Name

DKK2

UniProt Synonym Gene Names

Dickkopf-2; Dkk-2; hDkk-2

UniProt Entry Name

DKK2_HUMAN

NCBI Protein Information

dickkopf-related protein 2; hDkk-2; dickkopf-2; dickkopf 2 homolog; dickkopf homolog 2; dickkopf related protein-2

NCBI Summary for DKK2

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]

UniProt Comments for DKK2

DKK2: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Interacts with LRP5 and LRP6. Expressed in heart, brain, skeletal muscle and lung. Belongs to the dickkopf family.

Protein type: Inhibitor; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q25

Cellular Component: extracellular space

Biological Process: Wnt receptor signaling pathway; multicellular organismal development

Research Articles on DKK2

1. Our results provide strong evidence that DKK2 is a key player in Ewing sarcoma invasion and osteolysis and also in the differential phenotype of Ewing sarcoma cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DKK2 antibody

Reference Product	PubMed Publications
DKK1 antibody	>55 publications with DKK2 and DKK1
LRP6 antibody	>20 publications with DKK2 and LRP6
LRP5 antibody	>15 publications with DKK2 and LRP5
WIF1 antibody	>11 publications with DKK2 and WIF1
WNT7B antibody	>6 publications with DKK2 and WNT7B
WNT6 antibody	>4 publications with DKK2 and WNT6
WNT2B antibody	>3 publications with DKK2 and WNT2B
KREMEN2 antibody	>2 publications with DKK2 and KREMEN2

Pathways associated with anti-DKK2 antibody

Products by Pathway	Pathway Diagram
Presenilin Action In Notch And Wnt Signaling Pathway antibodies	Presenilin Action In Notch And Wnt Signaling Pathway Diagram
Wnt Signaling Pathway antibodies	Wnt Signaling Pathway Diagram
Wnt Signaling Pathway antibodies	Wnt Signaling Pathway Diagram

Diseases associated with anti-DKK2 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>20 publications with DKK2 and Neoplasms
Inflammation Antibodies	>6 publications with DKK2 and Inflammation
Kidney Diseases Antibodies	>3 publications with DKK2 and Kidney Diseases
Congenital Abnormalities Antibodies	>3 publications with DKK2 and Congenital Abnormalities
Disease Models, Animal Antibodies	>3 publications with DKK2 and Disease Models, Animal
Ovarian Diseases Antibodies	>2 publications with DKK2 and Ovarian Diseases
Abnormalities, Drug-Induced Antibodies	>2 publications with DKK2 and Abnormalities, Drug-Induced
Neoplasm Metastasis Antibodies	>2 publications with DKK2 and Neoplasm Metastasis
Cell Transformation, Neoplastic Antibodies	>2 publications with DKK2 and Cell Transformation, Neoplastic
Gonadal Disorders Antibodies	>2 publications with DKK2 and Gonadal Disorders

Organs/Tissues associated with anti-DKK2 antibody

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>31 publications with DKK2 and Bone
Embryonic Tissue Antibodies	>8 publications with DKK2 and Embryonic Tissue
Liver Antibodies	>7 publications with DKK2 and Liver
Eye Antibodies	>7 publications with DKK2 and Eye
Vascular Antibodies	>4 publications with DKK2 and Vascular
Uterus Antibodies	>4 publications with DKK2 and Uterus
Brain Antibodies	>4 publications with DKK2 and Brain
Heart Antibodies	>3 publications with DKK2 and Heart
Lung Antibodies	>2 publications with DKK2 and Lung
Placenta Antibodies	>1 publications with DKK2 and Placenta