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PZP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1560289

Pregnancy Zone protein is a 1, 482 amino acid secreted protein that belongs to the protease inhibitor I39 family and exists as multiple alternatively spliced isoforms. Expressed predominately in plasma and in late-pregnancy sera, Pregnancy Zone protein… More details

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Product Overview

Product Name
PZP, Polyclonal Antibody
Full Product Name
Anti PZP polyclonal antibody
Product Gene Name
anti-PZP antibody
Product Synonym Names
Pregnancy zone protein; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6; CPAMD6
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Other species were not tested
Form/Format
Liquid. Supplied as solution form in PBS, pH7.4, containing 0.05% proclin300, 50% glycerol.
Purity/Purification
Antigen affinity purification
Concentration
0.72 mg/ml (lot specific)
Preparation and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 degree C for frequent use. Store at -20 to -80 degree C for twelve months from the date of receipt.
Molecular Weight
164kDa
OMIM
176420
3D Structure
ModBase 3D Structure for P20742
Immunogen
Recombinant protein of human PZP (Asn341-Ser690)
Conjugation
Unconjugated

Product Categories/Family for anti-PZP antibody

Primary antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-PZP antibody
Immunohistochemistry (IHC), Immunocytochemistry (ICC)
Application Notes for anti-PZP antibody
ICC: 1:50~200
IHC: 1:50~100

Immunofluorescence (IF) of anti-PZP antibody

Rabbit Anti-PZP Polyclonal Antibody – Cat# MBS1560289

Product References and Citations for anti-PZP antibody

PMID: 1692292; PMID: 1989698; PMID: 16959974

Other Notes

Small volumes of anti-PZP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PZP purchase

MBS1560289 is an antibody targeting PZP. Also known as Anti PZP polyclonal antibody. Reactive in Human
Other species were not tested. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PZP. It may not necessarily be applicable to this product.

NCBI GI #
281185515
NCBI GeneID
5858
NCBI Accession #
P20742.4
UniProt Primary Accession #
P20742
UniProt Secondary Accession #
Q15273; Q2NKL2; Q7M4N7; A6ND27
UniProt Related Accession #
P20742
NCBI Official Full Name
Pregnancy zone protein
NCBI Official Synonym Full Names
pregnancy-zone protein
NCBI Official Symbol
PZP
NCBI Official Synonym Symbols
CPAMD6
UniProt Protein Name
Pregnancy zone protein
UniProt Synonym Protein Names
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6
Protein Family
Pregnancy zone protein
UniProt Gene Name
PZP
UniProt Synonym Gene Names
CPAMD6
UniProt Entry Name
PZP_HUMAN
NCBI Protein Information
pregnancy zone protein; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6

UniProt Comments for PZP

PZP: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12p13-p12.2

Cellular Component: extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity

Biological Process: female pregnancy
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Research Articles on PZP

1. Quantitative measurements using a multiple reaction monitoring assay showed a significant increase in plasma pregnancy-zone protein in presymptomatic Alzheimer disease compared with controls

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PZP antibody

 Reference Product  PubMed Publications
 SERPINC1 antibody  >2 publications with PZP and SERPINC1

Organs/Tissues associated with anti-PZP antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >13 publications with PZP and Liver
 Brain Antibodies  >11 publications with PZP and Brain
 Uterus Antibodies  >5 publications with PZP and Uterus
 Lung Antibodies  >1 publications with PZP and Lung
 Trachea Antibodies  >1 publications with PZP and Trachea
 Testis Antibodies  >1 publications with PZP and Testis
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