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PVRL2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1560316

Nectin 2, also named as PVRL2, CD112, HVEB, PRR2 and PVRR2, is an adhesion molecule widely expressed in cell lines of different lineages, including hematopoietic, neuronal, endothelial and epithelial cells. CD112 belongs to a new family of immunoglobulin-like… More details

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Product Overview

Product Name
PVRL2, Polyclonal Antibody
Full Product Name
Anti PVRL2 polyclonal antibody
Product Gene Name
anti-PVRL2 antibody
Product Synonym Names
Nectin cell adhesion molecule 2; PVRL2; NECTIN2; CD112; Poliovirus receptor-related protein 2; HVEB; Nectin-2; HveB; Herpes virus entry mediator B; PRR2; Herpesvirus entry mediator B
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Other species were not tested
Form/Format
Liquid. Supplied as solution form in PBS, pH7.4, containing 0.05% proclin300, 50% glycerol.
Purity/Purification
Antigen affinity purification
Concentration
0.5mg/ml (lot specific)
Preparation and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 degree C for frequentUse. Store at -20 to -80 degree C for twelve months from the date of receipt.
Molecular Weight
51,359 Da
OMIM
X80038 mRNA
3D Structure
ModBase 3D Structure for Q92692
Immunogen
Recombinant protein of human PVRL2 (Gln32-Pro350)
Conjugation
Unconjugated

Product Categories/Family for anti-PVRL2 antibody

Primary antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-PVRL2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PVRL2 antibody
WB: 1:2000-1:8000
IHC: 1:200-1:400

Immunofluorescence (IF) of anti-PVRL2 antibody

Rabbit Anti-PVRL2 Polyclonal Antibody – Cat# MBS1560316

Western Blot (WB) of anti-PVRL2 antibody

Rabbit Anti-PVRL2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS1560316

Other Notes

Small volumes of anti-PVRL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PVRL2 purchase

MBS1560316 is an antibody targeting PVRL2. Also known as Anti PVRL2 polyclonal antibody. Reactive in Human
Other species were not tested. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PVRL2. It may not necessarily be applicable to this product.

NCBI GI #
12643789
NCBI GeneID
5819
NCBI Accession #
Q92692.1
UniProt Primary Accession #
Q92692
UniProt Secondary Accession #
O75455; Q6IBI6; Q96J29; A8K5L5
UniProt Related Accession #
Q92692
NCBI Official Full Name
Nectin-2
NCBI Official Synonym Full Names
nectin cell adhesion molecule 2
NCBI Official Symbol
NECTIN2
NCBI Official Synonym Symbols
HVEB; PRR2; CD112; PVRL2; PVRR2
UniProt Protein Name
Nectin-2
UniProt Synonym Protein Names
Herpes virus entry mediator B; Herpesvirus entry mediator B; HveB; Nectin cell adhesion molecule 2
UniProt Gene Name
NECTIN2
UniProt Synonym Gene Names
Herpesvirus entry mediator B; HveB
NCBI Protein Information
nectin-2

NCBI Summary for PVRL2

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
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UniProt Comments for PVRL2

Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005).
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Research Articles on PVRL2

1. In the infection with 3 MLD50 (50 % mouse lethal dose), effective resistance was not observed in transgenic mice expressing nectin-2Ig.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PVRL2 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junctions Interactions Pathway antibodies  Adherens Junctions Interactions Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Cell-cell Junction Organization Pathway antibodies  Cell-cell Junction Organization Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram

Diseases associated with anti-PVRL2 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1 publications with PVRL2 and Necrosis

Organs/Tissues associated with anti-PVRL2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1 publications with PVRL2 and Blood
 Embryonic Tissue Antibodies  >1 publications with PVRL2 and Embryonic Tissue
 Placenta Antibodies  >1 publications with PVRL2 and Placenta
 Testis Antibodies  >1 publications with PVRL2 and Testis
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