PDL1 Antibody – Rabbit Polyclonal

Programmed cell death ligand 1 (PD-L1, CD274, or B7-H1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. PD-L1 is suggested as a negative regulator of T and B cell, and plays important role in mediating tolerance of lymphocytes to self-antigens. It is also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PD-1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33kDa, it is predicted to be 27-30kDa after signal peptide cleavage (PMID: 25609200, 17076679). The apparent molecular weight has also been reported as 45-70kDa, major glycosylated form of 45-50kDa and multiple post-translational modifications form of 65-70kDa (PMID: 18760278, 16493058).

Small volumes of anti-PDL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS1560328 is an antibody targeting PDL1. Also known as Anti PDL1 polyclonal antibody. Reactive in Human
Other species were not tested. Host: Rabbit.