Human ACE2 Recombinant Protein – Cat# MBS156035

ACE2 Human Recombinant Protein

Name: ACE2 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS156035
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS156035

Recombinant Human ACE2 is produced by Mammalian Cells expression system and the target gene encoding Ser19-Asp615 is expressed with C-His TagBackground: Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ACE2, Recombinant Protein

Full Product Name

Recombinant Human ACE2 protein

Product Gene Name

ACE2 recombinant protein

Product Synonym Names

ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; Metalloprotease MPROT15

Host

Mammalian Cells

Form/Format

Lyophilized. Lyophilized from PBS pH 7.4, 5% Trehalose, 5% Mannose?1mM EDTA

Purity/Purification

>90% as determined by SDS-PAGE

Preparation and Storage

Store at 2 to 8 degree C for one week.
Store at -20 to -80 degree C for twelve months from the date of receipt.
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Shipping: Ice packs

Molecular Weight

Predicted Molecular Mass: 71.54kDa

Sequence Positions

805

OMIM

300335

3D Structure

ModBase 3D Structure for Q9BYF1

Species

Human

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for ACE2 recombinant protein

Immunogen

Other Notes

Small volumes of ACE2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ACE2 purchase

MBS156035 is a recombinant protein targeting ACE2. Also known as Recombinant Human ACE2 protein. Host: Mammalian Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for ACE2. It may not necessarily be applicable to this product.

NCBI GI #

1700998532

NCBI Accession #

NP_001358344.1

UniProt Primary Accession #

Q9BYF1

GenBank Nucleotide #

NP_001358344.1

NCBI Official Full Name

angiotensin-converting enzyme 2

UniProt Protein Name

Angiotensin-converting enzyme 2

UniProt Synonym Protein Names

ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; ACEH; Metalloprotease MPROT15

Protein Family

Angiotensin-converting enzyme

UniProt Gene Name

ACE2

UniProt Synonym Gene Names

ACEH

UniProt Entry Name

ACE2_HUMAN

UniProt Comments for ACE2

ACE2: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. Interacts with ITGB1. Interacts with SARS-CoV and HCoV- NL63 spike glycoprotein. Up-regulated in failing heart. Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells. Expressed in heart, kidney, testis, and gastrointestinal system. Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. Belongs to the peptidase M2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.17.23; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: Xp22

Cellular Component: extracellular space; cell surface; cytoplasm; integral to membrane; plasma membrane; extracellular region; lipid raft

Molecular Function: peptidyl-dipeptidase activity; viral receptor activity; protein binding; metallopeptidase activity; carboxypeptidase activity; zinc ion binding; peptide hormone binding; endopeptidase activity; glycoprotein binding

Biological Process: virion attachment, binding of host cell surface receptor; entry of virus into host cell; maternal process involved in pregnancy; regulation of vasodilation; proteolysis; angiotensin maturation; regulation of systemic arterial blood pressure by renin-angiotensin; regulation of cell proliferation; regulation of cytokine production; cellular protein metabolic process; regulation of vasoconstriction; regulation of inflammatory response; angiotensin catabolic process in blood; receptor biosynthetic process; angiotensin mediated drinking behavior

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.