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Briakinumab (IL12B) Antibody – Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS1563675
PROMOTIONAL PRICING: 10% OFF web price. Discount is not applicable for bulk pricing such as 5x96T or 10x96T. Discount will be applied after order has been placed

MBS1563675 is an antibody targeting IL12B. Also known as Research Grade Briakinumab. Reactive in Human. More details

$475 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Briakinumab (IL12B), Monoclonal Antibody
Full Product Name
Research Grade Briakinumab
Product Gene Name
Product Synonym Names
ABT-874; J695; IL-12 subunit p40; IL12B; Interleukin-12 subunit beta; IL-12B; CLMF p40; NKSF2; NK cell stimulatory factor chain 2; Cytotoxic lymphocyte maturation factor 40 kDa subunit
Clonality
Monoclonal
Isotype
IgG1-lambda
Species Reactivity
Human
Form/Format
Liquid. PBS buffer, pH7.4
Purity/Purification
>95%; Protein A or G purified from cell culture supernatant.
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at +4 degree C short term (1-2 weeks). Store at -20 degree C 12 months. Store at -80 degree C long term.
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Molecular Weight
328
Chromosome Location
Chromosome: 5; NC_000005.9 (158741791..158757481, complement). Location: 5q31.1-q33.1
OMIM
161561
3D Structure
ModBase 3D Structure for P29460
Host Species
Human
CAS
339308-60-0

Product Categories/Family for anti-IL12B antibody

ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-IL12B antibody
Research Grade Briakinumab Biosimilar

SDS-Page of anti-IL12B antibody

SDS PAGE for Briakinumab
Anti-IL12B Monoclonal Antibody – Cat# MBS1563675

Product References and Citations for anti-IL12B antibody

A phase III, randomized, controlled trial of the fully human IL-12/23 mAb briakinumab in moderate-to-severe psoriasis, PMID: 22011907
A Review of Biologic Therapies Targeting IL-23 and IL-17 for Use in Moderate-to-Severe Plaque Psoriasis, PMID: 26714681
A Two-pronged Binding Mechanism of IgG to the Neonatal Fc Receptor Controls Complex Stability and IgG Serum Half-life, PMID: 28062799
ABT-874, a fully human monoclonal anti-IL-12/IL-23 antibody for the potential treatment of autoimmune diseases, PMID: 18465662
Antibodies in the Treatment of Psoriasis: IL-12/23 p40 and IL-17a, PMID: 27551698

Other Notes

Small volumes of anti-IL12B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IL12B. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
interleukin-12 subunit beta
NCBI Official Synonym Full Names
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
NCBI Official Symbol
IL12B
NCBI Official Synonym Symbols
CLMF; NKSF; CLMF2; NKSF2; IL-12B
UniProt Protein Name
Interleukin-12 subunit beta
UniProt Synonym Protein Names
Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40; NK cell stimulatory factor chain 2
Protein Family
UniProt Gene Name
IL12B
UniProt Synonym Gene Names
NKSF2; IL-12B; CLMF p40; NKSF2
UniProt Entry Name
IL12B_HUMAN
NCBI Protein Information
interleukin-12 subunit beta; CLMF p40; IL-12 subunit p40; IL12, subunit p40; interleukin 12, p40; interleukin-12 beta chain; NK cell stimulatory factor chain 2; cytotoxic lymphocyte maturation factor 40 kDa subunit; natural killer cell stimulatory factor

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-IL12B antibody

 Organ/Tissue Name  Pubmed Publications
 Mixed Antibodies  >2 publications with IL12B and Mixed
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