Anti-KLRC4-KLRK1 Monoclonal Antibody – Cat# MBS1563656

SDS PAGE for Tesnatilimab

Tesnatilimab (KLRC4-KLRK1) Antibody – Monoclonal

Name: KLRC4-KLRK1 Antibody; Monoclonal; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1563656
Price: 475 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1563656

MBS1563656 is an antibody targeting KLRC4-KLRK1. Also known as Research Grade Tesnatilimab. Reactive in Human. More details

$475 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Tesnatilimab (KLRC4-KLRK1), Monoclonal Antibody

Full Product Name

Research Grade Tesnatilimab

Product Gene Name

anti-KLRC4-KLRK1 antibody

Product Synonym Names

JNJ-64304500; KLRK1; NKG2D; Killer cell lectin-like receptor subfamily K member 1; NKG2-D-activating NK receptor; D12S2489E; NKG2-D type II integral membrane protein; NK cell receptor D; CD314

Clonality

Monoclonal

Isotype

IgG4-kappa

Species Reactivity

Human

Form/Format

Liquid. PBS buffer, pH7.4

Purity/Purification

>95%; Protein A or G purified from cell culture supernatant.

Concentration

1mg/ml (lot specific)

Preparation and Storage

Store at +4 degree C short term (1-2 weeks). Store at -20 degree C 12 months. Store at -80 degree C long term.
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Molecular Weight

25,274 Da

Chromosome Location

Chromosome: 12; NC_000012.11 (10524952..10562745, complement). Location: 12p

OMIM

611817

3D Structure

ModBase 3D Structure for P26718

Host Species

Human

CAS

2242758-08-1

Product Categories/Family for anti-KLRC4-KLRK1 antibody

Research Biosimilar

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-KLRC4-KLRK1 antibody

Research Grade Tesnatilimab Biosimilar

Other Notes

Small volumes of anti-KLRC4-KLRK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KLRC4-KLRK1. It may not necessarily be applicable to this product.

NCBI GI #

315221164

NCBI GeneID

100528032

NCBI Accession #

NP_001186734.1

UniProt Primary Accession #

P26718

UniProt Secondary Accession #

Q9NR41; A8K7K5; A8K7P4

UniProt Related Accession #

P26718

GenBank Nucleotide #

NM_001199805.1

NCBI Official Full Name

NKG2-D type II integral membrane protein

NCBI Official Symbol

KLRC4-KLRK1

UniProt Protein Name

NKG2-D type II integral membrane protein

UniProt Synonym Protein Names

Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor

UniProt Gene Name

KLRK1

UniProt Synonym Gene Names

D12S2489E; NKG2D

UniProt Entry Name

NKG2D_HUMAN

NCBI Protein Information

NKG2-D type II integral membrane protein; NK cell receptor D; NKG2-D-activating NK receptor; killer cell lectin-like receptor subfamily K member 1

NCBI Summary for KLRC4-KLRK1

This locus represents naturally occurring read-through transcription between the neighboring KLRC4 (killer cell lectin-like receptor subfamily C, member 4) and KLRK1 (killer cell lectin-like receptor subfamily K, member 1) genes on chromosome 12. The read-through transcript includes an alternate 5' exon and lacks a significant portion of the KLRC4 coding sequence, including the start codon, and it thus encodes the KLRK1 protein. [provided by RefSeq, Dec 2010]

UniProt Comments for KLRC4-KLRK1

KLRK1: Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes. 1 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.2-p12.3

Cellular Component: cell surface; integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: protein binding; receptor activity; carbohydrate binding

Biological Process: regulation of immune response; T cell costimulation; natural killer cell activation; innate immune response; cell differentiation; positive regulation of natural killer cell mediated cytotoxicity; signal transduction

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-KLRC4-KLRK1 antibody

Products by Pathway	Pathway Diagram
Malaria Pathway antibodies	Malaria Pathway Diagram
Malaria Pathway antibodies	Malaria Pathway Diagram
Natural Killer Cell Mediated Cytotoxicity Pathway antibodies	Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
Natural Killer Cell Mediated Cytotoxicity Pathway antibodies	Natural Killer Cell Mediated Cytotoxicity Pathway Diagram

Organs/Tissues associated with anti-KLRC4-KLRK1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>4 publications with KLRC4-KLRK1 and Blood