Anti-TNFRSF12A Monoclonal Antibody – Cat# MBS1563931

SDS PAGE for Enavatuzumab

Enavatuzumab (TNFRSF12A) Antibody – Monoclonal

Name: TNFRSF12A Antibody; Monoclonal; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1563931
Price: 475 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1563931

MBS1563931 is an antibody targeting TNFRSF12A. Also known as Research Grade Enavatuzumab. Reactive in Human. More details

$475 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Enavatuzumab (TNFRSF12A), Monoclonal Antibody

Full Product Name

Research Grade Enavatuzumab

Product Gene Name

anti-TNFRSF12A antibody

Product Synonym Names

PDL 192; FGF-inducible 14; TNFRSF12A; FN14; CD266; TweakR; Fibroblast growth factor-inducible immediate-early response protein 14; Tweak-receptor; Tumor necrosis factor receptor superfamily member 12A

Clonality

Monoclonal

Isotype

IgG1-kappa

Species Reactivity

Human

Form/Format

Liquid. PBS buffer, pH7.4

Purity/Purification

>95%; Protein A or G purified from cell culture supernatant.

Concentration

1mg/ml (lot specific)

Preparation and Storage

Store at +4 degree C short term (1-2 weeks). Store at -20 degree C 12 months. Store at -80 degree C long term.
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Molecular Weight

10,191 Da

OMIM

605914

3D Structure

ModBase 3D Structure for Q9NP84

Host Species

Humanized

CAS

1062149-33-0

Product Categories/Family for anti-TNFRSF12A antibody

Research Biosimilar

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-TNFRSF12A antibody

Research Grade Enavatuzumab Biosimilar

Product References and Citations for anti-TNFRSF12A antibody

Phase I Study of Enavatuzumab, a First-in-Class Humanized Monoclonal Antibody Targeting the TWEAK Receptor, in Patients with Advanced Solid Tumors, PMID: 29054986
Nuclear Factor κB is Required for Tumor Growth Inhibition Mediated by Enavatuzumab (PDL192), a Humanized Monoclonal Antibody to TweakR, PMID: 24409185
Expression of TweakR in breast cancer and preclinical activity of enavatuzumab, a humanized anti-TweakR mAb, PMID: 23073510
Predictive gene signature of response to the anti-TweakR mAb PDL192 in patient-derived breast cancer xenografts, PMID: 25375638
Fibroblast growth factor inducible (Fn14)-specific antibodies concomitantly display signaling pathway-specific agonistic and antagonistic activity, PMID: 23532848

Other Notes

Small volumes of anti-TNFRSF12A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFRSF12A. It may not necessarily be applicable to this product.

NCBI GI #

7706186

NCBI GeneID

51330

NCBI Accession #

NP_057723.1

UniProt Primary Accession #

Q9NP84

UniProt Secondary Accession #

Q9HCS0; D3DUA6

UniProt Related Accession #

Q9NP84

GenBank Nucleotide #

NM_016639.2

NCBI Official Full Name

tumor necrosis factor receptor superfamily member 12A

NCBI Official Synonym Full Names

tumor necrosis factor receptor superfamily, member 12A

NCBI Official Symbol

TNFRSF12A

NCBI Official Synonym Symbols

FN14; CD266; TWEAKR

UniProt Protein Name

Tumor necrosis factor receptor superfamily member 12A

UniProt Synonym Protein Names

Fibroblast growth factor-inducible immediate-early response protein 14; FGF-inducible 14; Tweak-receptor; TweakR; CD_antigen: CD266

Protein Family

Tumor necrosis factor receptor superfamily

UniProt Gene Name

TNFRSF12A

UniProt Synonym Gene Names

FN14; FGF-inducible 14; TweakR

UniProt Entry Name

TNR12_HUMAN

NCBI Protein Information

tumor necrosis factor receptor superfamily member 12A; FGF-inducible 14; fibroblast growth factor-inducible immediate-early response protein 14; tweak-receptor; type I transmembrane protein Fn14

UniProt Comments for TNFRSF12A

TweakR: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. Associates with TRAF1 and TRAF2, and probably also with TRAF3. By FGF1 and phorbol ester. Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis; Cell development/differentiation

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: ruffle; cell surface; plasma membrane; integral to membrane

Molecular Function: protein binding

Biological Process: substrate-bound cell migration, cell attachment to substrate; positive regulation of apoptosis; positive regulation of axon extension; angiogenesis; regulation of angiogenesis

Research Articles on TNFRSF12A

1. Results position TWEAK-Fn14 signaling through Mcl-1 as a significant mechanism for NSCLC tumor cell survival

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TNFRSF12A antibody

Reference Product	PubMed Publications
TNFSF12 antibody	>5 publications with TNFRSF12A and TNFSF12
TNFRSF25 antibody	>1 publications with TNFRSF12A and TNFRSF25

Pathways associated with anti-TNFRSF12A antibody

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
TWEAK Signaling Pathway antibodies	TWEAK Signaling Pathway Diagram

Diseases associated with anti-TNFRSF12A antibody

Disease Name	Pubmed Publications
Necrosis Antibodies	>14 publications with TNFRSF12A and Necrosis
Inflammation Antibodies	>9 publications with TNFRSF12A and Inflammation
Neoplasms, Experimental Antibodies	>4 publications with TNFRSF12A and Neoplasms, Experimental
Lung Neoplasms Antibodies	>3 publications with TNFRSF12A and Lung Neoplasms
Cardiovascular Diseases Antibodies	>3 publications with TNFRSF12A and Cardiovascular Diseases
Adenocarcinoma Antibodies	>3 publications with TNFRSF12A and Adenocarcinoma
Lung Diseases Antibodies	>3 publications with TNFRSF12A and Lung Diseases
Heart Diseases Antibodies	>2 publications with TNFRSF12A and Heart Diseases
Disease Models, Animal Antibodies	>2 publications with TNFRSF12A and Disease Models, Animal
Breast Neoplasms Antibodies	>1 publications with TNFRSF12A and Breast Neoplasms

Organs/Tissues associated with anti-TNFRSF12A antibody

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>7 publications with TNFRSF12A and Vascular
Lung Antibodies	>7 publications with TNFRSF12A and Lung
Muscle Antibodies	>5 publications with TNFRSF12A and Muscle
Blood Antibodies	>4 publications with TNFRSF12A and Blood
Eye Antibodies	>3 publications with TNFRSF12A and Eye
Kidney Antibodies	>2 publications with TNFRSF12A and Kidney
Heart Antibodies	>2 publications with TNFRSF12A and Heart
Bone Antibodies	>2 publications with TNFRSF12A and Bone
Brain Antibodies	>1 publications with TNFRSF12A and Brain
Intestine Antibodies	>1 publications with TNFRSF12A and Intestine