Rat Anti-CD274/PD-L1/B7-H1 Monoclonal Antibody – Cat# MBS1569721

CD274/PD-L1/B7-H1 Antibody – Rat Monoclonal

Name: CD274/PD-L1/B7-H1 Antibody; Monoclonal; Rat; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1569721
Price: 290 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1569721

MBS1569721 is an antibody targeting CD274/PD-L1/B7-H1. Also known as Anti-Mouse CD274/PD-L1/B7-H1 Antibody. Reactive in Mouse. Host: Rat. More details

$290 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD274/PD-L1/B7-H1, Monoclonal Antibody

Full Product Name

Anti-Mouse CD274/PD-L1/B7-H1 Antibody

Product Gene Name

anti-CD274/PD-L1/B7-H1 antibody

Product Synonym Names

B7-H1; Programmed cell death 1 ligand 1; PDCD1 ligand 1; PDCD1L1; B7 homolog 1; PDCD1LG1; PDL1; hPD-L1; Programmed death ligand 1; B7H1; PD-L1; CD274

Clonality

Monoclonal

Isotype

IgG1, kappa

Host

Rat

Species Reactivity

Mouse

Form/Format

Liquid; 0.01M PBS, pH 7.4.

Purity/Purification

>95%. Protein A or G purified.

Concentration

1mg/ml (lot specific)

Preparation and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at +4 degree C short term (1-2 weeks). Store at -20 degree C 12 months. Store at -80 degree C long term.

3D Structure

ModBase 3D Structure for Q9EP73

Conjugation

Unconjugated

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-CD274/PD-L1/B7-H1 antibody

ELISA (EIA), Flow Cytometry (FC/FACS/FCM)

Other Notes

Small volumes of anti-CD274/PD-L1/B7-H1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CD274/PD-L1/B7-H1. It may not necessarily be applicable to this product.

NCBI GI #

11230798

NCBI GeneID

60533

NCBI Accession #

NP_068693.1

UniProt Primary Accession #

Q9EP73

UniProt Related Accession #

Q9EP73

GenBank Nucleotide #

NM_021893.3

NCBI Official Full Name

programmed cell death 1 ligand 1

NCBI Official Synonym Full Names

CD274 antigen

NCBI Official Symbol

Cd274

NCBI Official Synonym Symbols

B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik

UniProt Protein Name

Programmed cell death 1 ligand 1

UniProt Synonym Protein Names

B7 homolog 1; B7-H1; CD_antigen: CD274

UniProt Gene Name

Cd274

UniProt Synonym Gene Names

B7h1; Pdcd1l1; Pdcd1lg1; Pdl1; PD-L1; PDCD1 ligand 1; Programmed death ligand 1; B7-H1

UniProt Entry Name

PD1L1_MOUSE

NCBI Protein Information

programmed cell death 1 ligand 1; B7 homolog 1; PDCD1 ligand 1; programmed death ligand 1

UniProt Comments for CD274/PD-L1/B7-H1

CD274: Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. Belongs to the immunoglobulin superfamily. BTN/MOG family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: cell surface; membrane; integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function: protein binding

Biological Process: cell surface receptor linked signal transduction; negative regulation of T cell proliferation; negative regulation of interleukin-10 production; negative regulation of activated T cell proliferation; negative regulation of interferon-gamma production; T cell costimulation; positive regulation of T cell proliferation; immune response; signal transduction; positive regulation of cell migration

Research Articles on CD274/PD-L1/B7-H1

1. In vivo blockade of PD-1/PD-L1 pathway on CD8 T cells, in combination with ETV treatment and DNA vaccination, potently enhanced the function of virus-specific T cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CD274/PD-L1/B7-H1 antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Costimulation By The CD28 Family Pathway antibodies	Costimulation By The CD28 Family Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
PD-1 Signaling Pathway antibodies	PD-1 Signaling Pathway Diagram

Diseases associated with anti-CD274/PD-L1/B7-H1 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>111 publications with CD274/PD-L1/B7-H1 and Inflammation
Liver Diseases Antibodies	>88 publications with CD274/PD-L1/B7-H1 and Liver Diseases
Necrosis Antibodies	>74 publications with CD274/PD-L1/B7-H1 and Necrosis
Neoplasms, Experimental Antibodies	>72 publications with CD274/PD-L1/B7-H1 and Neoplasms, Experimental
Nervous System Diseases Antibodies	>71 publications with CD274/PD-L1/B7-H1 and Nervous System Diseases
Adenocarcinoma Antibodies	>66 publications with CD274/PD-L1/B7-H1 and Adenocarcinoma
Lung Diseases Antibodies	>46 publications with CD274/PD-L1/B7-H1 and Lung Diseases
Lung Neoplasms Antibodies	>45 publications with CD274/PD-L1/B7-H1 and Lung Neoplasms
Kidney Diseases Antibodies	>44 publications with CD274/PD-L1/B7-H1 and Kidney Diseases
Recurrence Antibodies	>29 publications with CD274/PD-L1/B7-H1 and Recurrence

Organs/Tissues associated with anti-CD274/PD-L1/B7-H1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>785 publications with CD274/PD-L1/B7-H1 and Blood
Lung Antibodies	>75 publications with CD274/PD-L1/B7-H1 and Lung
Spleen Antibodies	>64 publications with CD274/PD-L1/B7-H1 and Spleen
Bone Marrow Antibodies	>63 publications with CD274/PD-L1/B7-H1 and Bone Marrow
Skin Antibodies	>47 publications with CD274/PD-L1/B7-H1 and Skin
Pancreas Antibodies	>28 publications with CD274/PD-L1/B7-H1 and Pancreas
Heart Antibodies	>25 publications with CD274/PD-L1/B7-H1 and Heart
Stomach Antibodies	>13 publications with CD274/PD-L1/B7-H1 and Stomach
Uterus Antibodies	>7 publications with CD274/PD-L1/B7-H1 and Uterus
Thymus Antibodies	>6 publications with CD274/PD-L1/B7-H1 and Thymus