HHV-5/HCMV Antibody – Monoclonal

Function: Receptor for a C-C type chemokine. Binds to a number of different CC-chemokines including CCL5/RANTES, CCL2/MCP-1, CCL3/MIP-1-alpha as well as CX3CL1/Fractalkine. Transduces signals resulting in the activation of MAP kinase signaling pathways and augmentation of intracellular calcium ion levels, leading to alterations in chemotactic behavior of vascular smooth muscle cells and macrophages. The US28 receptor also exhibits high levels of agonist-independent signaling activity and agonist-independent endocytosis. Interacts with endogenous Gaq/11 subunits and thereby constitutively activates phospholipase C. Ref.5 Ref.8

Subunit structure: Interacts with host GPRASP1; this interaction targets US28 to lysosomes for degradation. Ref.10

Subcellular location: Host cell membrane; Multi-pass membrane protein.

Post-translational modification: Phosphorylated. High phosphorylation occurs concomitantly with receptor endocytosis and correlate with low receptor presence at the plasma membrane. Ref.9

Sequence similarities: Belongs to the G-protein coupled receptor 1 family.

Sequence caution: The sequence CAA28338.1 differs from that shown. Reason: Frameshift at position 299. The sequence CAA35260.1 differs from that shown. Reason: Frameshift at position 299.