(NMNAT2) Recombinant Protein

Name: NMNAT2 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS157387
Price: 410 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS157387

MBS157387 is a recombinant protein targeting NMNAT2. Also known as Recombinant Human NMNAT2 protein, C-His Tag. Host: Baculovirus-Insect cells. More details

$410 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NMNAT2, Recombinant Protein

Full Product Name

Recombinant Human NMNAT2 protein, C-His Tag

Product Gene Name

NMNAT2 recombinant protein

Product Synonym Names

C1orf15; KIAA0479

Host

Baculovirus-Insect cells

Form/Format

Lyophilized. Lyophilized from PBS pH 7.4, 5% Trehalose, 5% Mannose, 1mM EDTA.

Purity/Purification

>90% as determined by SDS-PAGE

Preparation and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for ~12 months from the date of receipt.
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise

Molecular Weight

34,015 Da

OMIM

608701

3D Structure

ModBase 3D Structure for Q9BZQ4

Source

Human

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Construction

A DNA sequence encoding the human NMNAT2 (Met1~Gly307) was fused with the C-terminal His Tag

Product Categories/Family for NMNAT2 recombinant protein

Protein

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of NMNAT2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NMNAT2. It may not necessarily be applicable to this product.

NCBI GI #

24307989

NCBI GeneID

23057

NCBI Accession #

NP_055854.1

UniProt Primary Accession #

Q9BZQ4

UniProt Secondary Accession #

O75067; Q5T1Q3; Q8WU99; Q96QW1

UniProt Related Accession #

Q9BZQ4

GenBank Nucleotide #

NM_015039.3

NCBI Official Full Name

nicotinamide mononucleotide adenylyltransferase 2 isoform 1

NCBI Official Synonym Full Names

nicotinamide nucleotide adenylyltransferase 2

NCBI Official Symbol

NMNAT2

NCBI Official Synonym Symbols

PNAT2; C1orf15

UniProt Protein Name

Nicotinamide mononucleotide adenylyltransferase 2

UniProt Synonym Protein Names

Nicotinate-nucleotide adenylyltransferase 2 (EC:2.7.7.18); NaMN adenylyltransferase 2

UniProt Gene Name

NMNAT2

UniProt Synonym Gene Names

C1orf15; KIAA0479; NMN adenylyltransferase 2; NaMN adenylyltransferase 2

UniProt Entry Name

NMNA2_HUMAN

NCBI Protein Information

nicotinamide mononucleotide adenylyltransferase 2; NMN adenylyltransferase 2; NaMN adenylyltransferase 2; nicotinate-nucleotide adenylyltransferase 2; pyridine nucleotide adenylyltransferase 2

NCBI Summary for NMNAT2

This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for NMNAT2

NMNAT2: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NAAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Belongs to the eukaryotic NMN adenylyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; EC 2.7.7.18; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.7.7.1

Chromosomal Location of Human Ortholog: 1q25

Cellular Component: Golgi membrane; Golgi apparatus; late endosome; synapse; trans-Golgi network

Molecular Function: nicotinamide-nucleotide adenylyltransferase activity; nicotinate-nucleotide adenylyltransferase activity; ATP binding

Biological Process: NAD biosynthetic process; vitamin metabolic process; NAD metabolic process; water-soluble vitamin metabolic process

Research Articles on NMNAT2

1. Knockdown of NMNAT-2 significantly reduces cellular NAD(+) levels and protects cells from p53-dependent cell death upon DNA damage, suggesting an important functional role of NMNAT-2 in p53-mediated signaling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with NMNAT2 recombinant protein

Products by Pathway	Pathway Diagram
Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies	Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
Defective BTD Causes Biotidinase Deficiency Pathway antibodies	Defective BTD Causes Biotidinase Deficiency Pathway Diagram
Defective CD320 Causes Methylmalonic Aciduria Pathway antibodies	Defective CD320 Causes Methylmalonic Aciduria Pathway Diagram
Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway antibodies	Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway Diagram
Defective GIF Causes Intrinsic Factor Deficiency Pathway antibodies	Defective GIF Causes Intrinsic Factor Deficiency Pathway Diagram
Defective HLCS Causes Multiple Carboxylase Deficiency Pathway antibodies	Defective HLCS Causes Multiple Carboxylase Deficiency Pathway Diagram
Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway antibodies	Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway Diagram
Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway antibodies	Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway Diagram
Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway antibodies	Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway Diagram
Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway antibodies	Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway Diagram

Diseases associated with NMNAT2 recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>2 publications with NMNAT2 and Nervous System Diseases
Disease Models, Animal Antibodies	>2 publications with NMNAT2 and Disease Models, Animal
Hypertrophy Antibodies	>1 publications with NMNAT2 and Hypertrophy
Cardiovascular Diseases Antibodies	>1 publications with NMNAT2 and Cardiovascular Diseases
Lung Neoplasms Antibodies	>1 publications with NMNAT2 and Lung Neoplasms

Organs/Tissues associated with NMNAT2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>8 publications with NMNAT2 and Brain
Embryonic Tissue Antibodies	>4 publications with NMNAT2 and Embryonic Tissue
Muscle Antibodies	>3 publications with NMNAT2 and Muscle
Eye Antibodies	>1 publications with NMNAT2 and Eye
Blood Antibodies	>1 publications with NMNAT2 and Blood
Heart Antibodies	>1 publications with NMNAT2 and Heart
Lung Antibodies	>1 publications with NMNAT2 and Lung