CD121a/IL1R1 Human Recombinant Protein

This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]

IL-1RA: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Belongs to the interleukin-1 receptor family.

Protein type: EC 2.7.11.25; Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 2q12

Cellular Component: cell surface; membrane; integral to plasma membrane; plasma membrane; extracellular region

Molecular Function: interleukin-1, Type I, activating receptor activity; protein binding; signal transducer activity; transmembrane receptor activity; protease binding; platelet-derived growth factor receptor binding; interleukin-1 receptor activity

Biological Process: cell surface receptor linked signal transduction; regulation of inflammatory response; immune response