• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

FPN1/SLC40A1 Antibody – Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS1580202
PROMOTIONAL PRICING: 10% OFF web price. Discount is not applicable for bulk pricing such as 5x96T or 10x96T. Discount will be applied after order has been placed

MBS1580202 is an antibody targeting FPN1/SLC40A1. Also known as Research Grade Anti-Human FPN1/SLC40A1/Ferroportin (LY2928057). Reactive in Human. More details

$480 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FPN1/SLC40A1/Ferroportin, Monoclonal Antibody
Full Product Name
Research Grade Anti-Human FPN1/SLC40A1/Ferroportin (LY2928057)
Product Gene Name
anti-FPN1/SLC40A1 antibody
Product Synonym Names
LY2928057
Clonality
Monoclonal
Isotype
IgG
Species Reactivity
Human
Form/Format
Liquid; 0.01M PBS, pH 7.4.
Purity/Purification
>95% by SDS-PAGE.
Protein A or G purified from cell culture supernatant.
Concentration
1mg/ml (lot specific)
Preparation and Storage
Store at +4 degree C short term (1-2 weeks), -20 degree C 12 months, -80 degree C long term. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Molecular Weight
62,542 Da
OMIM
604653
3D Structure
ModBase 3D Structure for Q9NP59
Expression system
Mammalian cells
Target
Solute carrier family 40 member 1, SLC11A3, FPN1, SLC40A1, Iron-regulated transporter 1, IREG1, Ferroportin-1
Host Species
Human

Product Categories/Family for anti-FPN1/SLC40A1 antibody

Research Biosimilar
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-FPN1/SLC40A1 antibody
Research Grade Biosimilar

Other Notes

Small volumes of anti-FPN1/SLC40A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FPN1/SLC40A1. It may not necessarily be applicable to this product.

NCBI GI #
67633296
NCBI GeneID
30061
NCBI Accession #
AAY78556.1
UniProt Primary Accession #
Q9NP59
UniProt Secondary Accession #
Q6FI62; Q7Z4F8; Q8IVB2; Q9NRL0
UniProt Related Accession #
Q9NP59
NCBI Official Full Name
ferroportin 1 variant I, partial
NCBI Official Synonym Full Names
solute carrier family 40 (iron-regulated transporter), member 1
NCBI Official Symbol
SLC40A1
NCBI Official Synonym Symbols
FPN1; HFE4; MTP1; IREG1; MST079; MSTP079; SLC11A3
UniProt Protein Name
Solute carrier family 40 member 1
UniProt Synonym Protein Names
Ferroportin-1; Iron-regulated transporter 1
UniProt Gene Name
SLC40A1
UniProt Synonym Gene Names
FPN1; IREG1; SLC11A3
UniProt Entry Name
S40A1_HUMAN
NCBI Protein Information
solute carrier family 40 member 1; iron regulated gene 1; putative ferroportin 1 variant IIIA; putative ferroportin 1 variant IIIB; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3

NCBI Summary for FPN1/SLC40A1

The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]

UniProt Comments for FPN1/SLC40A1

SLC40A1: May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4). HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.

Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 2q32

Cellular Component: multivesicular body; synaptic vesicle; integral to plasma membrane; basolateral plasma membrane; cytoplasm; plasma membrane; integral to membrane; intracellular

Molecular Function: protein binding; iron ion transmembrane transporter activity

Biological Process: anatomical structure morphogenesis; cellular iron ion homeostasis; positive regulation of transcription from RNA polymerase II promoter; transmembrane transport; lymphocyte homeostasis; negative regulation of apoptosis

Disease: Hemochromatosis, Type 4
Show more

Research Articles on FPN1/SLC40A1

1. Manganese (Mn) transport carriers DMT1 and FPN1 mediate the apical uptake and basolateral exit of Mn in colonic epithelial Caco-2 cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FPN1/SLC40A1 antibody

 Reference Product  PubMed Publications
 HFE antibody  >51 publications with FPN1/SLC40A1 and HFE
 HAMP antibody  >41 publications with FPN1/SLC40A1 and HAMP
 TFR2 antibody  >35 publications with FPN1/SLC40A1 and TFR2
 HFE2 antibody  >10 publications with FPN1/SLC40A1 and HFE2
 SLC11A2 antibody  >6 publications with FPN1/SLC40A1 and SLC11A2
 HEPH antibody  >1 publications with FPN1/SLC40A1 and HEPH

Pathways associated with anti-FPN1/SLC40A1 antibody

 Products by Pathway  Pathway Diagram
 Iron Metabolism In Placenta Pathway antibodies  Iron Metabolism In Placenta Pathway Diagram
 Iron Uptake And Transport Pathway antibodies  Iron Uptake And Transport Pathway Diagram
 Metal Ion SLC Transporters Pathway antibodies  Metal Ion SLC Transporters Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway antibodies  Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway Diagram

Diseases associated with anti-FPN1/SLC40A1 antibody

 Disease Name  Pubmed Publications
 Hemochromatosis Antibodies  >58 publications with FPN1/SLC40A1 and Hemochromatosis
 Liver Diseases Antibodies  >15 publications with FPN1/SLC40A1 and Liver Diseases
 Anemia Antibodies  >14 publications with FPN1/SLC40A1 and Anemia
 Inflammation Antibodies  >5 publications with FPN1/SLC40A1 and Inflammation
 Neoplasms Antibodies  >4 publications with FPN1/SLC40A1 and Neoplasms
 Fibrosis Antibodies  >3 publications with FPN1/SLC40A1 and Fibrosis
 Breast Neoplasms Antibodies  >3 publications with FPN1/SLC40A1 and Breast Neoplasms
 Brain Diseases Antibodies  >2 publications with FPN1/SLC40A1 and Brain Diseases
 Disease Models, Animal Antibodies  >2 publications with FPN1/SLC40A1 and Disease Models, Animal
 Weight Loss Antibodies  >1 publications with FPN1/SLC40A1 and Weight Loss

Organs/Tissues associated with anti-FPN1/SLC40A1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >44 publications with FPN1/SLC40A1 and Blood
 Liver Antibodies  >34 publications with FPN1/SLC40A1 and Liver
 Heart Antibodies  >6 publications with FPN1/SLC40A1 and Heart
 Bone Antibodies  >6 publications with FPN1/SLC40A1 and Bone
 Intestine Antibodies  >6 publications with FPN1/SLC40A1 and Intestine
 Kidney Antibodies  >6 publications with FPN1/SLC40A1 and Kidney
 Spleen Antibodies  >5 publications with FPN1/SLC40A1 and Spleen
 Muscle Antibodies  >5 publications with FPN1/SLC40A1 and Muscle
 Brain Antibodies  >4 publications with FPN1/SLC40A1 and Brain
 Lung Antibodies  >3 publications with FPN1/SLC40A1 and Lung
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000